Drug “Pent‐Up” in Hollow Magnetic Prussian Blue Nanoparticles for NIR‐Induced Chemo‐Photothermal Tumor Therapy with Trimodal Imaging

Abstract

The study reports a biocompatible smart drug delivery system based on a doxorubicin (DOX) blending phase-change material of 1-pentadecanol loaded hollow magnetic Prussian blue nanoparticles, resulting in HMNP-PB@Pent@DOX. The system possesses concentration-dependent high thermogenesis (>50 °C) when applying a near-infrared (NIR) laser irradiation only for 5 min. Furthermore, the system realizes near "zero release" of drug and is efficiently triggered by NIR for drug delivery in an "on" and "off" manner, thus inducing cell apoptosis in vitro and in vivo. Moreover, the system clearly indicates tumor site with trimodal imaging of magnetic resonance imaging, photoacoustic tomography imaging, and infrared thermal imaging. Furthermore, the system achieves efficient chemo-photothermal combined tumor therapy in vivo with 808 nm laser irradiation for 5 min at 1.2 W cm , revealing the good tumor inhibition effect comparing with those of chemotherapy or photothermal therapy alone. The system is also confirmed to be biocompatible in regard to the mortality rate.

Hollow Structures Based on Prussian Blue and Its Analogs for Electrochemical Energy Storage and Conversion

“…Others a) [85] Ni-Fe cube HCl etching Ni-Fe yolk@frame structure Na + /Li + storage [96] Fe-Fe cube Epitaxial growth + HCl etching Fe-Fe shell-in-shell box - [93] Co-Co cube NH 3 etching Co-Co cage [66] Ni-Co cube Ni-Co cage [65] Ni-Fe cube Ni-Fe cage [67] Fe-Fe box Hard template Fe-Fe@Mn-Fe box Others [48] Polystyrene sphere Fe-Fe sphere [80] Mn-Fe cube Co-Fe@Ni-Cr box [79] Mn-Fe cube Cation exchange Co-Fe box Capacitor [86] Co-Fe cube Self-templating epitaxial growth Co-Fe frame and frame-like superstructure - [70] Molecules Spray-drying Cu-Fe superstructure - [105] Hollow PB-and PBA-derived structures Regarding the structural influence on electrochemical performance, different PB-and PBA-based hollow structures have their own merits and demerits. In general, closed single-shelled hollow structures can usually be obtained by more facile routes and applied in a wider range of applications, including LIBs, HSCs, and electrocatalysis.…”

“…[72] Copyright 2009, American Chemical Society. By employing this hard template method, other kinds of PB/ PBA hollow structures can be obtained, such as Co-Fe@Ni-Cr boxes, [79] Fe-Fe spheres, [80] and Fe-Fe@Mn-Fe boxes. [74] Copyright 2010, Royal Society of Chemistry.…”

Octopod PtCu Nanoframe for Dual-Modal Imaging-Guided Synergistic Photothermal Radiotherapy

“…At both time points, mice treated with OPCNs-PEG-FA have high Cu accumulation in liver. The biodistribution of the nanoparticles in kidney was 1.78% at 1 h and 4.79% at 48 h respectively, indicating the bio-clearance of nanoparticles through renal metabolism potentially 56 .…”

Cascade‐amplification of therapeutic efficacy: An emerging opportunity in cancer treatment

“…In a typical PDT process, a special type of light activatable agents termed “photosensitizers” is necessarily required, which would be delivered to the tumor site and release cytotoxic reactive oxygen species (ROS) under light irritation of specific wavelength (Dai et al, ; Li, Kolemen, Yoon, & Akkaya, ; Li, Lee, & Yoon, ). In comparison, PTT does not involve the generation of ROS through biochemical approaches but converts light into thermal energy to ablate the tumor tissues (Li et al, ; Xing, Zhang, Chen, Liu, & Cai, ; Zhou et al, ). Recent reports have also consistently revealed that PDT and PTT could not only directly damage the tumor cells but also trigger a series of biological events that may improve the treatment efficacy of other therapeutic modalities, of which the relevant designs and mechanisms are discussed individually below.…”