Octopod PtCu Nanoframe for Dual-Modal Imaging-Guided Synergistic Photothermal Radiotherapy

Abstract

Heavy atom nanoparticles have high X-ray absorption capacity and near infrared (NIR) photothermal conversion efficiency, which could be used as radio-sensitizers. We hypothesized that concave PtCu octopod nanoframes (OPCNs) would be an efficient nanoplatform for synergistic radio-photothermal tumor ablation.Methods: In this study, we newly exploited a folic acid-receptor (FR) mediated photothermal radiotherapy nanoagent base on OPCNs. OPCNs were synthesized with a hydrothermal method and then modified with polyethylene glycol (PEG) and folic acid (FA). A series of physical and chemical characterizations, cytotoxicity, targeting potential, endocytosis mechanism, biodistribution, systematic toxicological evaluation, pharmacokinetics, applications of OPCNs-PEG-FA for in vitro and in vivo infrared thermal imaging (ITI)/photoacoustic imaging (PAI) dual-modal imaging and synergistic photothermal radiotherapy against tumor were carried out.Results: The OPCNs-PEG-FA demonstrated good biocompatibility, strong NIR absorption and X-ray radio-sensitization, which enabling it to track and visualize tumor in vivo via ITI/PAI dual-modal imaging. Moreover, the as-synthesized OPCNs-PEG-FA exhibited remarkable photothermal therapy (PTT) and radiotherapy (RT) synergistic tumor inhibition when treated with NIR laser and X-ray.Conclusion: A novel multifunctional theranostic nanoplatform based on OPCNs was designed and developed for dual-modal image-guided synergistic tumor photothermal radiotherapy.

A DM1-doped porous gold nanoshell system for NIR accelerated redox-responsive release and triple modal imaging guided photothermal synergistic chemotherapy

“…Computed tomography (CT), a widely used clinical imaging modality, has a high spatial resolution and deep penetration range but characteristically low sensitivity. Photoacoustic (PA) and photothermal (PT) imaging are novel noninvasive technologies that have recently received significant attention in the context of preclinical imaging research [ 21 – 24 ]. PA imaging combines the deep penetration of acoustic imaging with the high sensitivity of optical imaging [ 25 ].…”

Emerging Strategies of Nanomaterial‐Mediated Tumor Radiosensitization

“…Copyright 2017, American Chemical Society. PTT&RT: Adapted with permission . Copyright 2018, Ivyspring International Publisher.…”

“…Therefore, when combing PTT with RT, the heat generated from PTT can elevate the oxygen level in cancer cells to make the cells more sensitive to radiation, and thus the RT therapeutic effect is availably strengthened. Up to date, a large number of literatures about PTT and RT synergetic therapy can be searched . And we roughly summarized the evolution trends of this synergetic strategy as follows.…”

Glutathione‐Depleting Nanoenzyme and Glucose Oxidase Combination for Hypoxia Modulation and Radiotherapy Enhancement

“…Various methods, including photothermal therapy, [ 16–21 ] photodynamic therapy, [ 22–25 ] and other strategies, [ 26,27 ] have been used to promote oxygenation. This can improve the sensitivity of cancerous cells to ionization radiation and achieve a similar treatment effect with a relatively low radiation dose to avoid damage to healthy tissues and organs.…”