Glutathione‐Depleting Nanoenzyme and Glucose Oxidase Combination for Hypoxia Modulation and Radiotherapy Enhancement

Lyu, Meng; Zhu, Delan; Kong, Xin Ying; Yang, Yang; Ding, Shuaijie; Zhou, Youwen; Hong, Quan; Duo, Yanhong; Bao, Zhirong

doi:10.1002/adhm.201901819

Cited by 68 publications

(45 citation statements)

References 57 publications

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“…Tirapazamine, in contrast, is a prodrug that is activated under hypoxic conditions and can be administered as a complementary approach together with radiotherapy to treat hypoxic tumors 26 , 27 . Other researchers have explored direct intratumoral oxygen delivery strategies using hemoglobin 28 , perfluorocarbon-based nanoplatforms 24 , or enzyme-like nanoparticles capable of mediating in situ oxygenation by degrading endogenous H 2 O 2 and, thereby, overcoming hypoxia 29 , 30 .…”

Section: Introductionmentioning

confidence: 99%

A platelet-mimicking theranostic platform for cancer interstitial brachytherapy

Lyu¹,

Chen²,

Liu³

et al. 2021

Theranostics

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Rational: Interstitial brachytherapy (BT) is a promising radiation therapy for cancer; however, the efficacy of BT is limited by tumor radioresistance. Recent advances in materials science and nanotechnology have offered many new opportunities for BT. Methods: In this work, we developed a biomimetic nanotheranostic platform for enhanced BT. Core-shell Au@AuPd nanospheres (CANS) were synthesized and then encapsulated in platelet (PLT)-derived plasma membranes. Results: The resulting PLT/CANS nanoparticles efficiently evaded immune clearance and specifically accumulated in tumor tissues due to the targeting capabilities of the PLT membrane coating. Under endoscopic guidance, a BT needle was manipulated to deliver appropriate radiation doses to orthotopic colon tumors while sparing surrounding organs. Accumulated PLT/CANS enhanced the irradiation dose deposition in tumor tissue while alleviating tumor hypoxia by catalyzing endogenous H 2 O 2 to produce O 2 . After treatment with PLT/CANS and BT, 100% of mice survived for 30 days. Conclusions: Our work presents a safe, robust, and efficient strategy for enhancing BT outcomes when adapted to treatment of intracavitary and unresectable tumors.

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Section: Introductionmentioning

confidence: 99%

A platelet-mimicking theranostic platform for cancer interstitial brachytherapy

Lyu¹,

Chen²,

Liu³

et al. 2021

Theranostics

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“…But it is reported that ROS levels in some tumors are lower than corresponding non-tumorigenic cells (Diehn et al, 2009). Hence, two main strategies appears to be the key to solve these problems: (1) accurate tumor delineation and image guidance technologies with higher resolution (Bhide and Nutting, 2010); (2) highefficiency radiosensitizers to specifically increase the radiation deposition in tumors (Zhu et al, 2020a), reduce tumor hypoxia (Lyu et al, 2020b) and increase the production of reactive oxygen species in tumor cells (Liu et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, high-Z elements such as gold (Xia et al, 2020;Zhu et al, 2020a), silver (He et al, 2020;Khochaiche et al, 2021), platinum (Luo et al, 2020) and other nanoparticles (Deng et al, 2018) have been extensively explored as radiosensitizers. The tumor microenvironment (TME) is abundent in hydrogen peroxide (Balkwill et al, 2012;Taddei et al, 2013;Chen et al, 2017;Lyu et al, 2020b). Thus, nanoparticles containing manganese dioxide which could catalyze hydrogen peroxide to generate oxygen was used for alleviating hypoxia in tumors regions (Abbasi et al, 2016;Yi et al, 2016) and hence fix the DSBs in cells after radiotherapy.…”

Section: Introductionmentioning

confidence: 99%

Iron-Palladium Decorated Carbon Nanotubes Achieve Radiosensitization via Reactive Oxygen Species Burst

Yang

et al. 2021

Front. Bioeng. Biotechnol.

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Radiotherapy is recommended as a modality for cancer treatment in clinic. However, cancerous cells were resistant to therapeutic irradiation due to its DNA repair. In this work, single-walled carbon nanotubes with unique physical properties of hollow structures and high specific surface area were introduced as carrier for iron-palladium (FePd) to obtain iron-palladium decorated carbon nanotubes (FePd@CNTs). On one hand, FePd nanoparticles possess significant ability in radiosensitization as previously reported. On the other hand, carbon nanotubes offer higher efficiency in crossing biological barriers, inducing the accumulation and retention of FePd nanoparticles within tumor tissue. In order to verify the radiosensitization effect of FePd@CNTs, both in vitro and in vivo experiments were conducted. These experiments showed that the FePd@CNTs exhibited remarkably better radiosensitization effect and more obvious accumulation than FePd NPs, suggesting a potential of FePd@CNTs in radiosensitization.

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“…Innovative MnO 2 nanoparticles (NPs) act as catalase in low-pH tumor microenvironments, leading to a reduced hypoxic state (Yang et al, 2017). A recent multi-use hollowed-out MnO 2 nanocatalyst successfully served its objectives to reduce hypoxic states and as a drug-delivery system (Lyu et al, 2020). Once introduced, this nanocatalyst accumulates within the kidneys and is eventually cleared out as Mn 2+ with minimal cytotoxicity effects (Zhao et al, 2014;.…”

Section: Introductionmentioning

confidence: 99%

A Novel Bionic Catalyst-Mediated Drug Delivery System for Enhanced Sonodynamic Therapy

Yang

Hua

Suo

et al. 2021

Front. Bioeng. Biotechnol.

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Ultrasound (US)-triggered sonodynamic therapy (SDT) proves itself to be a formidable tool in the fight against cancer, due to its large spectrum of uses as a non-invasive therapeutic measure, while also demonstrating itself to be a certain improvement upon traditional SDT therapeutics. However, tumor hypoxia remains to be a major challenge for oxygen-dependent SDT. This study describes the development of an innovative, multi-use, catalyst-based and improved SDT targeting cancer, through the employment of a sonosensitizing curcumin (Cur) load embedded within a MnO2 core, together with an extraneous tumor cell membrane component. The latter allows for efficient tumor recognition properties. Hollowed-out MnO2 allows for efficient drug delivery, together with catalyzing oxygen generation from hydrogen peroxide present in tumor tissue, leading to enhanced SDT efficacy through the induction of a reduced hypoxic state within the tumor. In addition, Cur acts as a cytotoxic agent in its own right. The results deriving from in vivo studies revealed that such a biomimetic approach for drug-delivery actually led to a reduced hypoxic state within tumor tissue and a raised tumor-inhibitory effect within mouse models. Such a therapeutic measure attained a synergic SDT-based tumor sensitization treatment option, together with the potential use of such catalysis-based therapeutic formulations in other medical conditions having hypoxic states.

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Glutathione‐Depleting Nanoenzyme and Glucose Oxidase Combination for Hypoxia Modulation and Radiotherapy Enhancement

Cited by 68 publications

References 57 publications

A platelet-mimicking theranostic platform for cancer interstitial brachytherapy

A platelet-mimicking theranostic platform for cancer interstitial brachytherapy

Iron-Palladium Decorated Carbon Nanotubes Achieve Radiosensitization via Reactive Oxygen Species Burst

A Novel Bionic Catalyst-Mediated Drug Delivery System for Enhanced Sonodynamic Therapy

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