Drug prescription in Italian Residential Facilities

Tomasi, Rodolfo; Girolamo, Giovanni de; Santone, Giovanni; Picardi, Angelo; Micciolo, Rocco; Semisa, Domenico; Fava, Silva; Progres, Gruppo Nazionale

doi:10.1017/s1121189x0000628x

Cited by 4 publications

(1 citation statement)

References 59 publications

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“…It is used in the treatment of up to 40% of patients with schizophrenia (Grohmann et al, 2004;Barbui et al, 2005a;Biancosino et al, 2005;Centorrino et al, 2005;Tomasi et al, 2005), and frequently represents a long-term treatment option (Ganguly et al, 2004). According to recent evidence, the prevalence of antipsychotic polypharmacy has been increasing (Grohmann et al, 2004), particularly since the advent of second-generation antipsychotics (SGAs), although some studies showed that SGAs were less likely to be given with another antipsychotic than were oral or depot first-generation antipsychotics (FGAs) (Jaffe and Levine, 2003).…”

Section: Introductionmentioning

confidence: 99%

Persistence with polypharmacy and excessive dosing in patients with schizophrenia treated in four European countries

Barbui

Nosè

Mazzi

et al. 2006

International Clinical Psychopharmacology

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The purpose of this study was to calculate the proportion of patients with schizophrenia receiving persistent antipsychotic polypharmacy and excessive dosing in four European countries; to test the hypothesis that excessive dosing and/or antipsychotic polypharmacy is associated with higher levels of psychopathology; and to establish whether use of second-generation antipsychotics is a protective or a risk factor for polypharmacy and excessive dosing. Participants with schizophrenia were recruited from patients under the care of psychiatric services serving geographical catchment areas in Croydon (UK), Verona (Italy), Amsterdam (Netherlands), and Leipzig (Germany). We defined patients persistently receiving high antipsychotic dose (i.e. excessive dosing) as those with a prescribed daily dose/defined daily dose ratio of >1.5 both at initial assessment and after 1 year of follow-up. Similarly, we defined patients persistently receiving polypharmacy as those being prescribed two or more antipsychotic drugs both at baseline and at follow-up. A sample of 375 participants with schizophrenia was analyzed. A proportion of 28% of patients persistently received high-dose antipsychotic drugs, and a proportion of 13% of patients persistently received antipsychotic polypharmacy. In the multivariate analysis, psychopathology was not a predictor of persistent polypharmacy and excessive dosing; similarly, use of second-generation antipsychotics was not associated with polypharmacy and excessive dosing; however, persistence with high antipsychotic doses was predicted by baseline use of first-generation antipsychotics and second-generation antipsychotics concurrently. Antipsychotic drug use for patients with schizophrenia is only sometimes satisfactory and offers the opportunity of improvement. Clinicians should consider that dose reduction strategies have been shown to be a feasible intervention in patients with schizophrenia.

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Section: Introductionmentioning

confidence: 99%

Persistence with polypharmacy and excessive dosing in patients with schizophrenia treated in four European countries

Barbui

Nosè

Mazzi

et al. 2006

International Clinical Psychopharmacology

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The validity of the severity–psychosis hypothesis in depression

Østergaard¹,

J²,

Søltoft-Jensen³

et al. 2012

Journal of Affective Disorders

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Italian social psychiatry research: What gets published in peer reviewed journals?

Galeazzi

Priebe²

2007

Epidemiol Psichiatr Soc

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Aims -To explore the current state of Italian social psychiatry research as evidenced by original papers published in peer-reviewed journals 2004-2006. Methods -Electronic databases and hand searches of leading peer-reviewed journals were used to identify original research papers published in 2004-2006, addressing a social psychiatric issue, having at least one Italian author, and reporting data from Italian samples. Results -A total of 174 papers were identified. A substantial proportion reported findings of international collaborative research. Quantitative methods dominated, with 86 papers on cross-sectional surveys. Only 18 papers showed results of intervention trials with pre and post measures. Most common target group were psychiatric patients in community mental health services which featured in 93 papers. Conclusions -There is a critical mass of Italian social psychiatry research, dominated by a few research centres and with considerable amount of international collaboration. The findings of this survey might reflect the relative shortage of national funding for social psychiatry research. Declaration of Interest: None.

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Drug prescription in Italian Residential Facilities

Abstract: Psychotropic drug prescription patterns for severe patients living in RFs are only sometimes satisfactory and offer the opportunity of improvement. Specific actions are required to improve prescription patterns for severe patients in RFs.

Cited by 4 publications

References 59 publications

Persistence with polypharmacy and excessive dosing in patients with schizophrenia treated in four European countries

Persistence with polypharmacy and excessive dosing in patients with schizophrenia treated in four European countries

The validity of the severity–psychosis hypothesis in depression

Italian social psychiatry research: What gets published in peer reviewed journals?

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