Drug Reaction with Eosinophilia and Systemic Symptoms

A posteriori diagnosis of DRESS syndrome induced by diazoxide in a patient with an insulinoma: a case report and review of the literature

“…DRESS syndrome is a delayed drug hypersensitivity reaction, occurring 2-6 weeks after the first intake of the offending drug. The time to onset of this reaction is therefore longer than that observed in most other SCAR (2), and is therefore largely responsible for the frequent diagnostic delay in this syndrome (21).…”

“…Its severity is due to systemic manifestations that can progress to multi-organ failure and be life-threatening. Its physiopathology is now better understood, involving a predisposing immunogenetic background and reactivation of herpesviruses dominated by the HHV-6 virus (21). DRESS syndrome is a delayed drug hypersensitivity reaction, occurring 2-6 weeks after the first intake of the offending drug.…”

“…The survey should look for those whose introduction dates back between 3 weeks and 3 months before the start of DRESS (22). In a systematic review of DRESS cases reported in the literature between 1997 and 2009, a total of 44 drugs were associated with the 172 reported cases (21). In another recent review of the literature published in 2018 (2), diazoxide was never reported to be responsible for DRESS syndrome.…”