Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome due to ethambutol

Gest, N.; Ingen‐Housz‐Oro, Saskia; Géner, G.; Bellanger, Martine; Henn, A.; Gallien, Sébastien; Flateau, C.

doi:10.1016/j.medmal.2018.03.001

Cited by 9 publications

(6 citation statements)

References 8 publications

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“…Ethambutol was preferred as the first drug for re-challenge as it is least associated to cause DRESS [8]. Similar to a previously reported case of ethambutol-induced DRESS [9], in this patient, worsening of skin lesions was seen within 12 hours of ethambutol re-administration. Ethambutol was stopped again immediately following which lesions improved.…”

Section: Discussionsupporting

confidence: 75%

Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome Associated with Ethambutol use: A Case Report

Kapur

Rehan

2019

CDS

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Background:Among the first line Anti-Tubercular Drugs (ATDs), ethambutol has been rarely associated to cause drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome.Case Report:A 34-year-old woman presented in an out-patient department of Dermatology with fever, skin eruptions, eosino- philia, hyperinflated lung fields and deranged liver enzymes after 35 days of the initiation of ATDs. The patient recovered completely after stopping ethambutol and administration of topical and sys- temic corticosteroids.Results and Conclusion:Based on the available evidences of de-challenge and re-challenge of suspected drugs, ethambutol was certainly implicated to cause DRESS syndrome.

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Section: Discussionsupporting

confidence: 75%

Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome Associated with Ethambutol use: A Case Report

Kapur

Rehan

2019

CDS

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“…7 Histological studies demonstrate unspecific inflammatory patterns such as eczema, interphase dermatitis, exanthematous pustules or generalized multiforme-like erythema. 8 A skin biopsy is not usually recommended for DRESS. According to the studies conducted by P.N Conan et.…”

Section: Discussionmentioning

confidence: 99%

“…al., a skin biopsy is usually required after discontinuing all the drugs that is suspected to involve DRESS. (8) If DRESS is confirmed, 2-6 months after the recovery, skin patch test is usually recommended. The results of the skin patch test for diagnosis can vary from one medicine to the next, and its negative predictive value is less than 100.…”

Section: Discussionmentioning

confidence: 99%

“…ISSN: 2250-1177 [4] CODEN (USA): JDDTAO Algorithm 1: 8 Discontinue anti-TB treatment for at least one month after DRESS recovery, then perform skin patch tests to guide drug re-introduction.When stopping anti-TB medicines is not an option, second-line TB therapy should be started temporarily.If immediate reintroduction of first-line TB drugs is needed, Rifampicin should be avoided, and a dermatology specialist should be consulted. 4 Systemic corticosteroids must be given when there is cardiac, respiratory, or severe hepatic involvement.…”

Section: Discussionmentioning

confidence: 99%

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ATT-Therapy Induced DRESS: A Case Report

Stanly

Sarah

et al. 2021

J. Drug Delivery Ther.

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A severe adverse reaction called Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS syndrome), is usually described by eosinophilia, fever, swollen lymph nodes, severe skin rash and extensive systemic association. It is distinguished by a lengthy latency period, which is characteristic drug reaction with eosinophilia and systemic symptoms (DRESS). Formerly known as drug-induced delayed multi-organ hypersensitivity syndrome (DIDMOHS) or drug-induced hypersensitivity (DIHS). There are a variety of clinical symptoms associated with the syndrome yet it is still poorly understood. Drugs most commonly implicate in Anticonvulsants are the most common cause of DRESS syndrome, followed by sulfonamides and a variety of anti-inflammatory medications.Anti-tubercular therapy (ATT) is rarely associated with DRESS syndromeWe present the case of a 60-year-old female patient who had previously been treated with Anti-tubercular Therapy for Tubercular Meningitis (ATT).She was admitted to the hospital with presenting complaints of vomiting, burning micturition, fever associated with chills, generalized swelling and reddish skin all over the body including facial puffiness. The problem was successfully resolved by refraining from the offending medication and administering supportive care. Thus, the case illustrates the necessity of considering anti-tubercular drug reactions even when symptoms are delayed. Keywords: Anti-tubercular Therapy (ATT), Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), Adverse drug reaction (ADR), Drug-induced, Systemic symptoms syndrome,

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“…DRESS caused by anti-TB drugs is rarely reported and is mostly due to rifampicin (36). A 39-year-old Cambodian woman with TB presented with DRESS syndrome with hypereosinophilia at 1,400 cells/mm 3 , which was diagnosed to be induced by ethambutol (37). Peripheral blood and pulmonary eosinophilia was evident in three pulmonary TB patients with elimination of eosinophilic inflammatory process in two of the patients with successful anti-TB treatment, and tissue pathology was mainly associated with the discharge of toxic eosinophil proteins (38, 39).…”

Section: Eosinophils and Tbmentioning

confidence: 99%

Eosinophil Polymorphonuclear Leukocytes in TB: What We Know so Far

2019

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Knowledge on the cellular immune responses to infection with Mycobacterium tuberculosis has improved drastically in recent years. Though eosinophils and hypereosinophilia are linked with the disease process of tuberculosis, there is paucity of information to prove the actual role played by these polymorphonuclear leukocytes. The aim of this review is to provide an overview of the existing literature on what is known so far about eosinophils and tuberculosis.

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Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome due to ethambutol

Cited by 9 publications

References 8 publications

Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome Associated with Ethambutol use: A Case Report

Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome Associated with Ethambutol use: A Case Report

ATT-Therapy Induced DRESS: A Case Report

Eosinophil Polymorphonuclear Leukocytes in TB: What We Know so Far

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