Drug-related problems among medical ward patients in Jimma university specialized hospital, Southwest Ethiopia

Tigabu, Bereket Molla; Daba, Daniel; Belete, Habte

doi:10.4103/2279-042x.132702

Cited by 44 publications

(78 citation statements)

References 12 publications

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“…From the literature review, Tigabu et al, has observed that the prevalence of DRPs in their study was found to be 73.5%. 17 Expecting similar results in our present study with 95% confidence interval (CI) and with 10% relative precision, the sample size was found to be 150 subjects. 150 patients satisfied the aforementioned criteria and enrolled for the study.…”

Section: Study Samplesupporting

confidence: 78%

Identification of Drug Related Problems by Clinical Pharmacist in Prescriptions with Polypharmacy: A Prospective Interventional Study

Greeshma¹,

Lincy²,

Maheswari³

et al. 2018

JYP

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Objectives: Drug Related Problems (DRPs) and prescriptions with polypharmacy may lead to increased health care cost, morbidity, mortality and decreased quality of life. The objective of the study was to assess the pattern of DRPs associated with polypharmacy. Methods: It is a hospital based prospective interventional study carried out for 6 months in the Department of General Medicine. The DRPs were identified by researchers during ward rounds by reviewing the patient case reports. Problems identified and recognized was documented and discussed with the concerned health care team. Results: During the study period, 150 patient case sheets were reviewed to identify 213 DRPs. The most common DRP was found to be Adverse Drug Reactions (ADRs) (45%) followed by needs additional drug therapy (26.8%), untreated indication (13.6%) and Drug-Drug Interactions (DDIs) (11.7%). Binary logistic regression was performed to identify the predictors of DRPs. It was observed that number of comorbidities (Adjusted odds ratio (AOR) = 3.68 (p < 0.001)), geriatric population and polypharmacy were the major predictor. Conclusion: The study highlights the importance of drug therapy review to minimize DRPs, ADRs, polypharmacy, framing of new deprescribing guidelines and algorithms for drugs which are utilized inappropriately, deprescribing of redundant drugs during routine clinical practice and appointment of clinical pharmacist in hospitals to achieve better therapeutic outcomes and improved patient care.

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Section: Study Samplesupporting

confidence: 78%

Identification of Drug Related Problems by Clinical Pharmacist in Prescriptions with Polypharmacy: A Prospective Interventional Study

Greeshma¹,

Lincy²,

Maheswari³

et al. 2018

JYP

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“…It accounts for 62.4% of the total DTPs (236/378). It was also common in two other studies done at different hospitals of Ethiopia which were reported as 32.6% and 90.7% 14,15 . From these reports, it has been shown that there are variations in the prevalence among different settings.Such discrepancies might be explained in terms of availability of comprehensive treatment guidelines and professionals involved in the identification of DTPs particularly availability of clinical pharmacists in the clinical settings.…”

Section: Discussionmentioning

confidence: 68%

Untitled

2017

IJPSR

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Background: The objective of this study was to assess drug therapy problems (DTPs) and their predictors among hypertensive patients on follow up at Dil-Chora Referral Hospital, Ethiopia. Methods: Hospital based cross-sectional study involving medical record review was conducted from February-to-April 2015 using a structured questionnaire and this was complemented by a face-to-face interview. Adult hypertensive patients aged ≥18 years who were on follow-up for at least 3-months were enrolled in the study using a convenient sampling method. Data analysis was done using SPSS software version 16.0. Multiple logistic regressions were fitted and odds ratios with 95%CI were calculated to identify factors associated with DTPs. Results: The study included 271 hypertensive patients. Mean age was 57.73±12.13. One hundred sixty three (60.1%) were females. More than half of the respondents (50.6%) had comorbid condition and diabetes was the most common. More than 71% of patients were found to have at least one DTP and the mean number of DTPs per patient was 1.39±1.28. Need additional drug therapy(62.4%) and non-adherence(32.8%) were the two most common DTPs. Presence of comorbidity (AOR=5.74, 95%CI; 2.49-13.00), taking ≥3 medications per day (AOR=7.04, 95%CI; 2.33-21.25), and uncontrolled blood pressure (BP) (AOR=7.68, 95%CI; 3.70-15.90) were factors associated with DTPs. Conclusions: DTPs are common among hypertensive patients on follow up and the most common were need additional drug therapy and non-adherence to medications. Pharmacist interventions in drug therapy would help physicians in early identification and prevention of DTPs so that a joint effort between physicians and pharmacists should be made.

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“…The average knowledge assessment score per person increased from 0.22 to 0.85 with the aid of patient counseling using PIL card (30 patients). This is by a study conducted by Varkey et al, (2007), which showed that the average number of discrepancies decreased from 5.24 to 2.46 per patient after patient counseling 17 .…”

Section: Fig 2: Percentage Of Intervention Acceptancementioning

confidence: 92%

Untitled

2019

IJPSR

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Stroke is a medical condition in which poor blood flow to the brain results in cell death and is the second most common cause of death after coronary artery disease. Stroke patients with added co-morbidities on an average are prescribed with 6-10 medications which increase the potential for Drug-Related Problems (DRPs) including inappropriate dose or indication for medication and Adverse Drug Events (ADEs). DRPs may be defined as "an event or circumstance involving drug therapy that actually or potentially interferes with desired health outcomes." Several studies support medication reconciliation as a mean to reduce ADEs and improve medication use safety. Medication reconciliation is the "process of comparing a patient's medication orders to all the medications that the patient has been taking." Hence, the aim was to assess the impact of medication reconciliation and patient counseling in stroke patients along with identification and categorization of DRPs and conducting patient counseling with the aid of PIL card. The most prominent DRP reported it was associated with treatment effectiveness. The correlation between age, comorbidities, and polypharmacy with the incidence of DRPs were found to be statistically significant. Inappropriate drug selection was the major cause of DRPs. 66.26% of the total DRPs were completely resolved, and 9.43% were partially solved. Patient counseling and medication alert card had a significant role in conducting reconciliation. An appropriate tool like PCNE can assist clinical pharmacists and other healthcare professionals to systematically identify, categorize, and report DRPs in a timely manner.

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Drug-related problems among medical ward patients in Jimma university specialized hospital, Southwest Ethiopia

Cited by 44 publications

References 12 publications

Identification of Drug Related Problems by Clinical Pharmacist in Prescriptions with Polypharmacy: A Prospective Interventional Study

Identification of Drug Related Problems by Clinical Pharmacist in Prescriptions with Polypharmacy: A Prospective Interventional Study

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