Drug-Related Problems in Patients with Benign Prostatic Hyperplasia: A Cross Sectional Retrospective Study

Huri, Hasniza Zaman; Xin, Chong Hui; Sulaiman, Che Zuraini

doi:10.1371/journal.pone.0086215

Cited by 24 publications

(21 citation statements)

References 45 publications

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“…Numerous studies have noted that elderly patients are at increased risk of DRPs during the medication use process, which can lead to adverse clinical outcomes . This may be related to polypharmacy, pharmacokinetics/pharmacodynamics, and cognitive and functional alterations among elderly people .…”

Section: Discussioncontrasting

confidence: 52%

“…Regarding the causes of DRPs, C1.3 (“Inappropriate combination of drugs, or drugs and food”), C1.4 (“Inappropriate duplication of therapeutic group or active ingredient”), and C1.6 (“Too many drugs prescribed for indication”) were the most frequently reported in our study (Table ). In other studies, inadequate dose, inadequate interval, inappropriate duplication, potential interactions, and drug not taken or not administered were more common . Collectively, these findings suggest that the inappropriate duplication and combination of drugs were common factors leading to DRPs.…”

Section: Discussionmentioning

confidence: 69%

“…In other studies, inadequate dose, inadequate interval, inappropriate duplication, potential interactions, and drug not taken or not administered were more common. 15,27,29,32 Collectively, these findings suggest that the inappropriate duplication and combination of drugs were common factors leading to DRPs.…”

Section: Discussionmentioning

confidence: 91%

“…Numerous studies have noted that elderly patients are at increased risk of DRPs during the medication use process, which can lead to adverse clinical outcomes. 6,[11][12][13]26,27 This may be related to polypharmacy, pharmacokinetics/pharmacodynamics, and cognitive and functional alterations among elderly people. 28 Nonetheless, one study found that DRPs among a non-elderly group of patients with diabetes (56.7%) were slightly more common than among an elderly group with diabetes.…”

Section: Discussionmentioning

confidence: 99%

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Cross‐sectional investigation of drug‐related problems among adults in a medical center outpatient clinic: application of virtual medicine records in the cloud

Wang

Yeh

et al. 2016

Pharmacoepidemiology and Drug

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Section: Discussioncontrasting

confidence: 52%

Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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Cross‐sectional investigation of drug‐related problems among adults in a medical center outpatient clinic: application of virtual medicine records in the cloud

Wang

Yeh

et al. 2016

Pharmacoepidemiology and Drug

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“…Benign prostatic hyperplasia (BPH) is a disease that affects 50% of men over 60 years old and 90% in men over 85 years old (Huri, Xin, & Sulaiman, 2014). It is associated with lower urinary tract symptoms (LUTS).…”

Section: Introductionmentioning

confidence: 99%

Inflammatory pathway employed by Red Maca to treat induced benign prostatic hyperplasia in rats

et al. 2020

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Benign prostatic hyperplasia (BPH) is a pathology characterised by an increase in prostate size associated with low urinary tract symptoms. Finasteride (F), a 5a‐reductase inhibitor, is the standard treatment for BPH reducing prostate weight but also sexual desire. The Peruvian plant known as Red Maca (RM) (Lepidium meyenii) inhibits BPH in rats and mice. The aim of the study was to assess the inflammatory effect of RM and finasteride in rats with testosterone enanthate (TE)‐induced BPH. Thirty rats were divided into 5 groups: Control, TE (50 mg/rat), TE + F (0.6 mg/kg), and two groups of TE + RM 40/80 (40 or 80 mg). After treatments, tumour necrosis factor alpha (TNFa), interleukin 4 (IL4) and interferon gamma (INFg) as well as testosterone and oestradiol were evaluated and inflammatory cells (neutrophils, mast cells and lymphocytes) in prostate were quantified. Red Maca and finasteride treatments decreased inflammatory cells counts in prostate, inhibiting TNFa by different pathways. Finasteride increased IL4 whereas Red Maca increased INFg. In conclusion, data suggest that finasteride acts on Th2 response by increasing IL4 in prostate, while Red Maca acts on Th1 response mediated by INFg.

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Association of 5α-Reductase Inhibitors With Dementia, Depression, and Suicide

et al. 2022

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ImportanceIn recent decades, there has been increased interest in the possible adverse neurological effects of 5α-reductase inhibitors (5-ARIs), which have been used mainly for benign prostatic hyperplasia and androgenic alopecia. Numerous studies and reports have indicated associations of 5-ARIs with depression and suicide. However, most of these studies had methodological shortcomings, and very little is known about the potential association of 5-ARIs with dementia.ObjectiveTo investigate the association of 5-ARI use with all-cause dementia, Alzheimer disease, vascular dementia, depression, and suicide.Design, Setting, and ParticipantsThis Swedish register-based cohort study included 2 236 876 men aged 50 to 90 years between July 1, 2005, and December 31, 2018. Statistical analyses were performed from September 15, 2021, to May 25, 2022.Main Outcomes and MeasuresA diagnosis of all-cause dementia, Alzheimer disease, vascular dementia, depression, or completed suicide.ExposuresA recorded prescription in the Swedish national prescription register of finasteride or dutasteride and duration of use.ResultsOf 2 236 876 men (median age at the start of follow-up, 55 years [IQR, 50-65 years] and at treatment initiation, 73 years [IQR, 66-80 years]), 70 645 (3.2%) started finasteride treatment, and 8774 (0.4%) started dutasteride treatment. Men taking finasteride or dutasteride were at increased risk of all-cause dementia (finasteride: hazard ratio [HR], 1.22 [95% CI, 1.17-1.28]; dutasteride: HR, 1.10 [95% CI, 1.01-1.20]), Alzheimer disease (finasteride: HR, 1.20 [95% CI, 1.10-1.31]; dutasteride: HR, 1.28 [95% CI, 1.09-1.50]), vascular dementia (finasteride: HR, 1.44 [95% CI, 1.30-1.58]; dutasteride: HR, 1.31 [95% CI, 1.08-1.59]), and depression (finasteride: HR, 1.61 [95% CI, 1.48-1.75]; dutasteride: HR, 1.68 [95% CI, 1.43-1.96]). However, the magnitude of the association decreased over time, and the findings became statistically nonsignificant with continuous exposures over 4 years, except for depression, which showed a constant risk over time, with no differences between finasteride and dutasteride. In contrast, 5-ARIs were not associated with suicide (finasteride: HR, 1.22 [95% CI, 0.99-1.49]; dutasteride: HR, 0.98 [95% CI, 0.62-1.54]).Conclusions and RelevanceThis cohort study found that, while men receiving 5-ARI treatment showed a higher risk for dementia in the initial periods after starting treatment, the decreasing magnitude of the association over time suggested that the risk may be, entirely or in part, due to increased dementia detection among patients with benign prostate enlargement. Both finasteride and dutasteride were similarly associated with depression with a constant risk over time, while neither drug was associated with suicide. Prescribing clinicians and potential users should be aware of the possible risks for depression associated with 5-ARI use.

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Drug-Related Problems in Patients with Benign Prostatic Hyperplasia: A Cross Sectional Retrospective Study

Cited by 24 publications

References 45 publications

Cross‐sectional investigation of drug‐related problems among adults in a medical center outpatient clinic: application of virtual medicine records in the cloud

Cross‐sectional investigation of drug‐related problems among adults in a medical center outpatient clinic: application of virtual medicine records in the cloud

Inflammatory pathway employed by Red Maca to treat induced benign prostatic hyperplasia in rats

Association of 5α-Reductase Inhibitors With Dementia, Depression, and Suicide

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