Drug Release Control and Enhancement Using Carriers With Different Concentrations of Capmul® MCM C8

Bayan, Mohammad F.

doi:10.22159/ijap.2021v13i1.39742

Cited by 6 publications

(7 citation statements)

References 39 publications

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“…The used concentration of the bioavailability enhancer, capmul MCM C8, has significantly increased the release profile of the 5-amino salicylic acid, as demonstrated by D1, D2 and D7, D8 at each pH. This can be contributed to forming micelles within the polymeric matrix by the capmul ® MCM C8, thus enhancing the dissolution and release of the 5-amino salicylic acid [19]. The release profile of the model drug was also decreased significantly with an increasing concentration of the crosslinker (EGDMA), as demonstrated by F4, F5, and F6 at each pH.…”

Section: In Vitro Drug Release Studiesmentioning

confidence: 98%

“…Shailendrakumar et al [18] employed a capmul ® MCM product with palm oil to improve the oral bioavailability of pentoxifylline. In another work, Bayan et al [19] reported the potential use of capmul MCM C8 to improve the dissolution of poorly soluble drugs. The produced polymeric formulations (Table 1) were loaded with 5-amino salicylic acid as a model dug, which is characterized by poor solubility/permeability and used as a firstchoice drug in the treatment of inflammatory bowel diseases that affect mainly the colon.…”

Section: Preparation Of Smart Polymeric Formulationsmentioning

confidence: 99%

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Development of Polymeric-Based Formulation as Potential Smart Colonic Drug Delivery System

et al. 2022

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Conventional oral formulations are mainly absorbed in the small intestine. This limits their use in the treatment of some diseases associated with the colon, where the drug has to act topically at the inflammation site. This paved the way for the development of a smart colonic drug delivery system, thereby improving the therapeutic efficacy, reducing the dosing frequency and potential side effects, as well as improving patient acceptance, especially in cases where enemas or other topical preparations may not be effective alone in treating the inflammation. In healthy individuals, it takes an oral medication delivery system about 5 to 6 h to reach the colon. A colonic drug delivery system should delay or prohibit the medication release during these five to six hours while permitting its release afterward. The main aim of this study was to develop a smart drug delivery system based on pH-sensitive polymeric formulations, synthesized by a free-radical bulk polymerization method, using different monomer and crosslinker concentrations. The formulations were loaded with 5-amino salicylic acid as a model drug and Capmul MCM C8 as a bioavailability enhancer. The glass transition temperature (Tg), tensile strength, Young’s modulus, and tensile elongation at break were all measured as a part of the dried films’ characterization. In vitro swelling and release studies were performed to assess the behavior of the produced formulations. The in vitro swelling and release evaluation demonstrated the potential ability of the developed system to retard the drug release at conditions mimicking the stomach and small intestine while triggering its release at conditions mimicking the colon, which indicates its promising applicability as a potential smart colonic drug delivery system.

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Section: In Vitro Drug Release Studiesmentioning

confidence: 98%

Section: Preparation Of Smart Polymeric Formulationsmentioning

confidence: 99%

Development of Polymeric-Based Formulation as Potential Smart Colonic Drug Delivery System

et al. 2022

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“…Due to these classical treatment strategies, the patient immune system is damaged by the drugs, which leads to side effects. Recently, biomedical researchers have had a great interest in the uses of targeted drug delivery methods in cancer treatments [ 35 , 36 , 37 , 38 ]. Today, several synthetic drugs are available in the market for lung cancer cells targeting epidermal growth factor receptor (EGFR).…”

Section: Resultsmentioning

confidence: 99%

Facile Fabrication of Methyl Gallate Encapsulated Folate ZIF-L Nanoframeworks as a pH Responsive Drug Delivery System for Anti-Biofilm and Anticancer Therapy

2022

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Zeolitic imidazole frameworks are emerging materials and have been considered an efficient platform for biomedical applications. The present study highlights the simple fabrication of methyl gallate encapsulated folate-ZIF-L nanoframeworks (MG@Folate ZIF-L) by a simple synthesis. The nanoframeworks were characterized by different sophisticated instruments. In addition, the drug-releasing mechanism was evidenced by in vitro releasing kinetics at various pH conditions. The anti-biofilm potential confirmed by the biofilm architectural deformations against human infectious pathogens MRSA and N7 clinical strains. Furthermore, anticancer efficacy assessed against A549 lung cancer cells. The result reveals that the MG@Folate ZIF-L exposed a superior cytotoxic effect due to the pH-responsive and receptor-based drug-releasing mechanism. Based on the unique physicochemical and biological characteristics of nanoframeworks, it has overcome the problems of undesired side effects and uncontrolled drug release of existing drug delivery systems. Finally, the in vitro toxicity effect of MG@Folate ZIF-L was tested against the Artemia salina (A. salina) model organism, and the results show enhanced biocompatibility. Overall, the study suggested that the novel MG@Folate ZIF-L nanoframeworks is a suitable material for biomedical applications. It will be very helpful to the future design for targeted drug delivery systems.

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“…The size of the polymer also affects this behaviour, as it affects the surface area available for fluid penetration. The ability to control this behaviour encourages the use of polymers in many pharmaceutical drug delivery systems [1][2][3][4][5][6][7]. The pellets' swelling was examined in phosphate-buffered saline (PBS).…”

Section: Pellets' Swelling Assessmentmentioning

confidence: 99%

“…Targeted drug delivery to the colon has attracted the attention of many researchers owing to its tremendous advantages over systemic drug administration, including increased drug potency and efficacy and reduced adverse drug reactions [1,2]. Colonic drug delivery systems have been used to treat a plethora of bowel diseases encompassing colorectal carcinoma, ulcerative colitis, diverticulitis, Crohn's disease, and irritable bowel syndrome [3][4][5]. Colon-specific drug delivery has long been used to enhance therapeutic effectiveness by reducing unwanted absorption in other regions of the gastrointestinal tract, guaranteeing that the whole drug dose is specifically delivered to the site of interest in the colon [6,7].…”

Section: Introductionmentioning

confidence: 99%

Smart Pellets for Controlled Delivery of 5-Fluorouracil

et al. 2022

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This work aimed to develop a new one-pot and readily scaled-up formulation capable of retaining 5-fluorouracil and prolonging its release to obtain a site-specific medication delivery for the potential treatment of colorectal cancer. Six polymer-based formulations were successfully produced using a thermal bulk polymerization method and loaded with 5-fluorouracil, which is a chemotherapeutic agent used in the treatment of colorectal carcinoma. The pellets produced were characterized by measuring the glass transition temperature, tensile strength, Young’s modulus, and tensile elongation at break. Studies on in vitro swelling and release were carried out in phosphate-buffered saline to evaluate the behaviour of the developed system. The Young’s modulus, glass transition temperature, and tensile strength all increased significantly as the crosslinker concentration increased, but the fracture strain value reduced significantly. The in vitro swelling profile of the produced formulations was significantly reduced by increasing crosslinking density. Less than 27% cumulative drug release was achieved for all formulations after 5 h of starting the release study. The highest cumulative drug release reached after 24 h was 69%. The developed drug delivery system demonstrated the ability to delay the release of 5-fluorouracil in upper gastrointestinal tract-mimicking conditions, while permitting its release in a controlled way afterward, which makes it promising for the potential delivery of 5-fluorouracil to the colon.

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Drug Release Control and Enhancement Using Carriers With Different Concentrations of Capmul® MCM C8

Cited by 6 publications

References 39 publications

Development of Polymeric-Based Formulation as Potential Smart Colonic Drug Delivery System

Development of Polymeric-Based Formulation as Potential Smart Colonic Drug Delivery System

Facile Fabrication of Methyl Gallate Encapsulated Folate ZIF-L Nanoframeworks as a pH Responsive Drug Delivery System for Anti-Biofilm and Anticancer Therapy

Smart Pellets for Controlled Delivery of 5-Fluorouracil

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