Drug release from hydroethanolic gels. Effect of drug's lipophilicity (logP), polymer–drug interactions and solvent lipophilicity

Sawant, Prashant D.; Luu, Dewitt; Ye, Rose; Buchta, Richard M.

doi:10.1016/j.ijpharm.2010.06.008

Cited by 75 publications

(41 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…DAS et al (2010) used FTIR to determine the potential interactions between the components of nanoparticles (alginate, chitosan and pluronic) containing curcumin. SAWANT et al (2010) demonstrated by FTIR spectra that there was no interaction between the drug lidocaine encapsulated in hydrophobic Eudragit polymers, since the spectrum did not presented any changes with respect to the spectra of the components when analyzed isolated.…”

Section: Resultsmentioning

confidence: 97%

Characterization of progesterone loaded biodegradable blend polymeric nanoparticles

et al. 2015

View full text Add to dashboard Cite

The encapsulation of progesterone in poly (hydroxybutirate-co-hydroxyvalerate) (PHBV), poly (ε-caprolactone) (PCL), poly (L-lactic acid) (PLLA) nanoparticles and PHBV/PCL and PHBV RESUMO A encapsulação de progesterona em nanopartículas de poli (hidroxibutirato-co-hidroxivalerato) (PHBV), poli (ε-caprolactona) (PCL), poli (L-ácido lático) (PLLA) e em nanopartículas blenda de PHBV/PCL e PHBV

show abstract

Section: Resultsmentioning

confidence: 97%

Characterization of progesterone loaded biodegradable blend polymeric nanoparticles

et al. 2015

View full text Add to dashboard Cite

show abstract

“…The n value of the Krossmeyer-Peppas (KP) model gives information on the mechanism of drug release from the formulations. The results suggested that the release of the drug from the MPs followed non-Fickian kinetics (n ≈ 0.6) ( Figure 13 and Table 5) [40].…”

Section: In Vitro Drug Release Studiesmentioning

confidence: 95%

Encapsulation of vegetable organogels for controlled delivery applications

Sagiri

Sethy

Pal

et al. 2012

Designed Monomers and Polymers

View full text Add to dashboard Cite

The present study deals with the encapsulation of vegetable organogels in alginate microparticles (MPs). Mango butter (MB) and cocoa butter (CB) are natural organogels, which are being used in the preparation of pharmaceutical formulations. In addition to these, mustard oil (MO) was used as the control. The thermal stability of MB and CB can be enhanced by encapsulating them and can be used in oral drug-delivery formulations. Double emulsification method was followed for the preparation of MPs. By this method, spherical MPs were synthesized and the sphericity was confirmed by doing light microscopy and scanning electron microscopy. The size range of MPs was 107 ± 53 μm, 79 ± 43 μm, and 112 ± 78 μm for MPs encapsulating MO, MB, and CB, respectively. The melting endotherms of MPs with MB and CB were in exact match with the melting points of MB and CB. This confirmed the existence of MB and CB within the MPs. The encapsulation of the vegetable organogels altered the release pattern of the drug, metronidazole. The drug release kinetics suggested that the release pattern followed the non-Fickian kinetics. The MPs were found to be hemocompatible in nature and have shown good mucoadhesive and swelling properties. Based on the preliminary results, it was suggested that the vegetable organogels can be encapsulated in alginate MPs and used as drug-delivery vehicles.

show abstract

“…In addition, similar to transdermal delivery, the transmucosal delivery is a phenomenon governing the permeation properties and partitioning into the skin of drug and the drug release from the polymer matrix. Lidocaine HCl is a hydrophilic drug with Log P ≤ 0 [23]. The fact that the latter showed slower permeation of drug from LDC-P3 compared to that of LDC-P1 patches could also be explained by the higher affinity of lidocaine HCl to the hydrated PVP, which lowered the tendency of lidocaine HCl to migrate and part into the mucosa.…”

Section: In Vitro Permeationmentioning

confidence: 99%

“…It is very soluble in water [23]. It has been reported that lidocaine HCl diffused passively through porcine buccal membrane [24].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Poly (Vinyl Alcohol)–poly (Vinyl Pyrrolidone) Mucoadhesive Buccal Patches for Delivery of Lidocaine HCL

Jaipakdee

Limpongsa

2018

Int J App Pharm

View full text Add to dashboard Cite

Objective: The objectives of this study were to prepare and characterize a buccal mucoadhesive patch using poly (vinyl alcohol) (PVA), poly (vinyl pyrrolidone) (PVP) as a mucoadhesive matrix, Eudragit S100 as a backing layer, and lidocaine HCl as a model drug.Methods: Lidocaine HCl buccal patches were prepared using double casting technique. Molecular interactions in the polymer matrices were studied using attenuated total reflectance-fourier transform infrared spectroscopy (ATR-FTIR), differential scanning calorimetry (DSC) and X-ray diffractometry. Mechanical and mucoadhesive properties were measured using texture analyzer. In vitro permeation of lidocaine HCl from the patch was conducted using Franz diffusion cell.Results: Both of the free and lidocaine HCl patches were smooth and transparent, with good flexibility and strength. ATR-FTIR, DSC and X-ray diffractometry studies confirmed the interaction of PVA and PVP. Mechanical properties of matrices containing 60% PVP were significantly lower than those containing 20% PVP (*P<0.05). Mucoadhesive properties had a tendency to decrease with the concentration of PVP in the patch. The patch containing 60% PVP had significantly lower muco-adhesiveness than those containing 20% PVP (*P<0.05). In vitro permeation revealed that the pattern of lidocaine HCl permeation started with an initial fast permeation, followed by a slower permeation rate. The initial permeation fluxes follow the zero-order model of which rate was not affected by the PVP concentrations in the PVA/PVP matrix. Conclusion:Mucoadhesive buccal patches fabricated with PVA/PVP were successfully prepared. Incorporation of PVP in PVA/PVP matrix affected the strength of polymeric matrix and mucoadhesive property of patches.

show abstract

Drug release from hydroethanolic gels. Effect of drug's lipophilicity (logP), polymer–drug interactions and solvent lipophilicity

Cited by 75 publications

References 29 publications

Characterization of progesterone loaded biodegradable blend polymeric nanoparticles

Characterization of progesterone loaded biodegradable blend polymeric nanoparticles

Encapsulation of vegetable organogels for controlled delivery applications

Preparation and Characterization of Poly (Vinyl Alcohol)–poly (Vinyl Pyrrolidone) Mucoadhesive Buccal Patches for Delivery of Lidocaine HCL

Contact Info

Product

Resources

About