Drug release from tableted wet granulations comprising cellulosic (HPMC or HPC) and hydrophobic component

Kiortsis, S.; Kachrimanis, Kyriakos; Broussali, Th.; Malamataris, S.

doi:10.1016/j.ejpb.2004.05.004

Cited by 88 publications

(54 citation statements)

References 20 publications

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“…Table 5 shows that the release mechanism can be described as a mixed of Fickian and anomalous diffusion (matrix swelling and erosion) mechanism. Similar conclusions were obtained by Kiortis et al (2005) in a study of SD release from HPMC and HPC matrices.…”

Section: Resultssupporting

confidence: 86%

Correlação in vitro in vivo para formas farmacêuticas sólidas de liberação modificada contendo diclofenaco de sódio

Mourão¹

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Section: Resultssupporting

confidence: 86%

Correlação in vitro in vivo para formas farmacêuticas sólidas de liberação modificada contendo diclofenaco de sódio

Mourão¹

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“…Tablets with HPMC can be produced by direct compression but often granulation is necessary [4,9]. High shear and fluid bed granulation were successfully applied to improve the flowability of formulations with HPMC [4,5,9,[10][11][12][13][14][15][16], often requiring hydro-alcoholic granulation liquids as granulation with water yielded lumps as well as fines due to the irregular wetting of the formulation.…”

Section: Introductionmentioning

confidence: 99%

Continuous twin screw granulation of controlled release formulations with various HPMC grades

Vanhoorne

Janssens

Vercruysse

et al. 2016

International Journal of Pharmaceutics

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HPMC is a popular matrix former to formulate tablets with extended drug release. Tablets with HPMC are preferentially produced by direct compression. However, granulation is often required prior to tableting to overcome poor flowability of the formulation. While continuous twin screw granulation has been extensively evaluated for granulation of immediate release formulations, twin screw granulation of controlled release formulations including the dissolution behavior of the formulations received little attention. Therefore, the influence of the HPMC grade (viscosity and substitution degree) and the particle size of theophylline on critical quality attributes of granules (continuously produced via twin screw granulation) and tablets was investigated in the current study. Formulations with 20 or 40% HPMC, 20% theophylline and lactose were granulated with water at fixed process parameters via twin screw granulation.The torque was influenced by the viscosity and substitution degree of HPMC, but was not a limiting factor for the granulation process. An optimal L/S ratio was selected for each formulation based on the granule size distribution. The granule size distributions were influenced by the substitution degree and concentration of HPMC and the particle size of theophylline. Raman and UV spectroscopic analysis on 8 sieve fractions of granules indicated an inhomogeneous distribution of theophylline over the size fractions. However, this phenomenon was not correlated with the hydration rate or viscosity of HPMC. Controlled release of theophylline could be obtained over 24 h with release profiles close to zero-order.The release of theophylline could be tailored via selection of the substitution degree and viscosity of HPMC.

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“…14 The determinants of non-compliant behavior are generally complex and poorly understood. 15 In the USA, several factors including psychosocial, demographic, and medical related characteristics have been identified as attributable to non-adherence with secondary prophylaxis for rheumatic fever among low-income families at a child and family therapy clinic.…”

Section: Introductionmentioning

confidence: 99%

Low adherence to secondary prophylaxis among clients diagnosed with rheumatic fever, Jamaica

Thompson

Brown

Edwards

et al. 2014

Pathogens and Global Health

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Objectives:To determine the level of adherence and possible barriers to secondary prophylaxis among clients with rheumatic fever in Kingston, Jamaica. Methods: Cross-sectional survey of 39 clients diagnosed with rheumatic fever, receiving penicillin prophylaxis for more than a year using a 22-item self-administered questionnaire on adherence to secondary prophylaxis and knowledge of rheumatic fever. The patients' records were reviewed to determine the number of prophylaxis injections the patients received for the year 2010. Results: The majority of participants (74%) were females and 51% were adults. Only 48.7% had a high level of adherence. The majority (72%) had low knowledge levels regarding their illness, while only 5% had a high knowledge level score. Most clients (70%) strongly agreed that nurses and doctors encouraged them to take their prophylaxis. However, over 60% reported that they travelled long distances and or waited long periods to get their injections. One-third reported that they missed appointments because of fear of injections and having to take time off from work or school. Discussion: Clients attending the health centers studied had limited knowledge about rheumatic fever. Barriers to adherence included fear of the injections, long commutes, and long waiting periods at the facilities studied.

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Drug release from tableted wet granulations comprising cellulosic (HPMC or HPC) and hydrophobic component

Cited by 88 publications

References 20 publications

Correlação in vitro in vivo para formas farmacêuticas sólidas de liberação modificada contendo diclofenaco de sódio

Correlação in vitro in vivo para formas farmacêuticas sólidas de liberação modificada contendo diclofenaco de sódio

Continuous twin screw granulation of controlled release formulations with various HPMC grades

Low adherence to secondary prophylaxis among clients diagnosed with rheumatic fever, Jamaica

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