Drug resistance in cancer: mechanisms and tackling strategies

Haider, Tanweer; Pandey, Vikas; Banjare, Nagma; Gupta, Prem N.; Soni, Vandana

doi:10.1007/s43440-020-00138-7

Cited by 182 publications

(133 citation statements)

References 194 publications

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“…MDR refers to the development of resistance by cancer cells to anticancer drugs having different structures and functions [129]. This phenomenon typically arises due to various mechanisms and involves intrinsic and extrinsic factors, such as drug inactivation, EMT, DNA repair alterations and epigenetics, inhibition of cell death related pathways (apoptosis, senescence, necrosis, autophagy), drug efflux and reduced drug uptake, intracellular signalling pathways, changes in membrane lipids, tumour microenvironment, cancer stem cells (CSCs) and membrane transporters [130][131][132][133]. Different mechanisms have been shown to contribute to chemoresistance in CRC when patients are treated with the currently available CRC treatments, such as 5-FU and its analogues, OXA, Cisplatin or DOX.…”

Section: Drug Resistance In Crcmentioning

confidence: 99%

The Mechanistic Roles of ncRNAs in Promoting and Supporting Chemoresistance of Colorectal Cancer

Micallef

Baron

2021

ncRNA

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Colorectal Cancer (CRC) is one of the most common gastrointestinal malignancies which has quite a high mortality rate. Despite the advances made in CRC treatment, effective therapy is still quite challenging, particularly due to resistance arising throughout the treatment regimen. Several studies have been carried out to identify CRC chemoresistance mechanisms, with research showing different signalling pathways, certain ATP binding cassette (ABC) transporters and epithelial mesenchymal transition (EMT), among others to be responsible for the failure of CRC chemotherapies. In the last decade, it has become increasingly evident that certain non-coding RNA (ncRNA) families are involved in chemoresistance. Research investigations have demonstrated that dysregulation of microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) contribute towards promoting resistance in CRC via different mechanisms. Considering the currently available data on this phenomenon, a better understanding of how these ncRNAs participate in chemoresistance can lead to suitable solutions to overcome this problem in CRC. This review will first focus on discussing the different mechanisms of CRC resistance identified so far. The focus will then shift onto the roles of miRNAs, lncRNAs and circRNAs in promoting 5-fluorouracil (5-FU), oxaliplatin (OXA), cisplatin and doxorubicin (DOX) resistance in CRC, specifically using ncRNAs which have been recently identified and validated under in vivo or in vitro conditions.

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Section: Drug Resistance In Crcmentioning

confidence: 99%

The Mechanistic Roles of ncRNAs in Promoting and Supporting Chemoresistance of Colorectal Cancer

Micallef

Baron

2021

ncRNA

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“…Malignant melanoma is a type of skin cancer and responsible for the vast majority of skin cancer deaths; it begins with the abnormal proliferation of cells known as melanocytes [ 5 ]. Chemotherapy, surgery, and radiotherapy are common cancer treatments, but their nonspecific action and severe side effects are cancer treatment’s biggest obstacles [ 6 , 7 ]. To bypass the side effects, developing new green drugs, especially essential oils (EO) s, has recently received more attention [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Chitosan nanoparticles containing limonene and limonene-rich essential oils: potential phytotherapy agents for the treatment of melanoma and breast cancers

Alipanah

Farjam

Zarenezhad

et al. 2021

BMC Complement Med Ther

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Background Melanoma and breast cancers are two common cancers worldwide. Due to the side effects of chemotherapy drugs and the occurring resistance against them, the development of green drugs has been received more attention. Methods The anticancer effects of three essential oils from the Citrus family and their identified major constituents (limonene) were first investigated against melanoma and breast cancer cell lines (A-375 and MDA-MB-468). By preparing chitosan nanoparticles containing them, an attempt was then made to improve their effectiveness. Results Chitosan nanoparticles containing Citrus sinensis and Citrus limon essential oils with IC50s of 0.03 and 0.124 μg/mL on A-375 cells, and 23.65 and 40.32 μg/mL on MDA-MB-468 showed distinct anticancer efficacies. Conclusion The prepared formulations could thus be considered as green anticancer agents in complementary medicine and therapies.

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“…These components include extracellular factors such as blood vessels, endothelial, myeloid, lymphoid, and growth factors, soluble factors, extracellular matrix, pH, oxygenation, and stromal cells. The effect of tumor microenvironment on drug resistance is highly related to the cancer cells and TME components responses to drugs (12) (13).…”

Section: Tumor Microenvironmentmentioning

confidence: 99%

Drug Resistance Mechanisms on Colorectal Cancer

Kurter

Yeşil²,

Daskin

et al. 2021

Journal of Basic and Clinical Health Sciences

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Standard treatment for colorectal cancer includes surgery, radiotherapy, and chemotherapy. Conventional chemotherapeutic agents used in colorectal cancer such as 5-fluorouracil, capecitabine which is oral form of 5-fluorouracil, irinotecan, and oxaliplatin. One of the major challenges in chemotherapy considered as drug resistance. Drug resistance occurs in many different mechanisms such as alteration in tumor microenvironment, growth kinetics, genetic variations, and tumor heterogeneity. These cytotoxic agents are used in combination form to overcome drug resistance on colorectal cancer. They can also be used in combination with cytotoxic agents as bevacizumab and cetuximab. Combination therapy depends on tumor burden, type, stage, and molecular characteristics. It is crucial to choose the combination therapy to be applied by taking these factors into consideration. In this review, current drug resistance mechanisms were discussed and then mechanisms of conventional chemotherapy related resistance were explained.

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Drug resistance in cancer: mechanisms and tackling strategies

Cited by 182 publications

References 194 publications

The Mechanistic Roles of ncRNAs in Promoting and Supporting Chemoresistance of Colorectal Cancer

The Mechanistic Roles of ncRNAs in Promoting and Supporting Chemoresistance of Colorectal Cancer

Chitosan nanoparticles containing limonene and limonene-rich essential oils: potential phytotherapy agents for the treatment of melanoma and breast cancers

Drug Resistance Mechanisms on Colorectal Cancer

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