Drug Resistance Pattern of Mycobacterium Tuberculosis Complex at a Medical Center in Central Taiwan, 2003–2007

Yu, Chia-Chuan; Chang, Chih-Yen; Liu, Chun-Eng; Shih, Li-Fong; Hsiao, Ju-Hua; Chen, Changhua

doi:10.1016/s1684-1182(10)60045-x

Cited by 14 publications

(10 citation statements)

References 14 publications

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“…In addition, the majority 5/9 of the isolates were designated three-drug resistant. The relationship between history of receiving anti-TB treatment and MDR has been clearly described in several studies [3,9,23,24]. Surprisingly, our study noted that MDR-TB prevalence is significantly higher in male patients (6/9) which are consistent with a recent report by Abate et al [24].…”

Section: Discussionsupporting

confidence: 92%

Drug Susceptibility Patterns of Mycobacterium tuberculosis Isolated from Patients with Pulmonary Tuberculosis in Tripoli-Libya

Albarouni¹,

Aboguttaia²,

Alamri³

et al. 2014

J Mycobac Dis

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Background: The emergence and spread of drug resistant and multidrug resistance are a global health problem. The susceptibility patterns of M. tuberculosis isolates against anti-tuberculosis drugs forms an important aspect of the control programs at the local level. The aim of this study was to determine the pattern of the susceptibility of drugs to M. tuberculosis isolates from patients with pulmonary tuberculosis in Tripoli, Libya. Methods: Drug Susceptibility Test (DST) was performed on 261 isolates of M. tuberculosis by BD BACTEC MGIT 960 SIRE system. The drugs tested were: isoniazid (INH), rifampicin (RIF), streptomycin (SM) and ethambutol (EMB). Results: All isolates (261) were confirmed as M. tuberculosis complex and showed different resistance patterns: 8.8% to INH; 5.7% to RIF; 8.8% to SM; and 9.0% to EMB. Rifampicin was the lowest detected resistance first-line antibiotics studied. One drug resistant was observed in 18.0%; 3.8% were resistant to two drugs; and 2.3% were resistant to a combination of three-drugs. Of the total 261 cases, 217 were designated as new untreated patients and 44 as previously treated patients. In terms of resistance to any drug, there was a significant difference between the two categories (P<0.014). However, there was no significant difference between new and previously treated patients in relation to one drug resistant (P=0.4). Meanwhile, there was a significant difference in relation to two drug resistant (P<0.005), Nine (20.5%) of the isolates designated multi-drug resistant (MDR) were obtained only from previously treated patients. None of newly treated cases had isolates resistant to three-drugs nor MDRs. Conclusion: This preliminary study indicated the low prevalence of drug resistance M. tuberculosis (MTB) among previously treated patients in Tripoli.

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Section: Discussionsupporting

confidence: 92%

Drug Susceptibility Patterns of Mycobacterium tuberculosis Isolated from Patients with Pulmonary Tuberculosis in Tripoli-Libya

Albarouni¹,

Aboguttaia²,

Alamri³

et al. 2014

J Mycobac Dis

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“…The prevalence of drug resistance in previously treated cases was higher than new cases for each drug alone as well as for all six drugs, as reported previously [2,7,8]. This suggests that retreatment is deficient and poses a threat to continued transmission, which has not yet manifested itself among new patients.…”

Section: Discussionsupporting

confidence: 69%

Rates and risk factors for drug resistance tuberculosis in Northeastern China

et al. 2013

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BackgroundDrug-resistant tuberculosis (TB) has emerged as a major challenge toward TB control and prevention. In Lianyungang city, the extent and trend of drug resistant TB is not well known. The objective of the survey was to assess drug resistance pattern of MTB and risk factors for drug resistant TB, including multidrug resistance tuberculosis (MDR-TB) in this area.MethodsWe performed drug susceptibility testing on Mycobacterium tuberculosis (MTB) isolates with first- and second-line anti-tuberculosis drugs of 1012 culture positive TB cases by using the proportion method, who were consecutively enrolled from January 2011 to December 2012 in Lianyungang city, China. The patterns of drug resistance in MTB were investigated and multiple logistic regression analysis was performed to assess the risk factors for drug resistant TB.ResultsAmong the 1012 strains tested, 308 (30.4%) strains were resistant to at least one first-line drug; the prevalence of MDR-TB was 88 (8.7%), 5 (0.5%) strains were found to be extensively drug-resistant tuberculosis (XDR-TB). Female gender was a risk factor for MDR-TB (adjusted odds ratio (aOR) 1.763, 95% CI (1.060-2.934). The aged 28–54 years was significantly associated with the risk of MDR-TB with an aOR: 2.224, 95% CI (1.158-4.273) when compared with those 65 years or older. Patients with previous treatment history had a more than 7-fold increased risk of MDR-TB, compared with those never previously treated.ConclusionsThe burden of drug resistant TB cases is sizeable, which highlights an urgent need to reinforce control, detection and treatment strategies for drug resistant TB.

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“…The prevalence of drug resistance TB in previously treated cases was higher than new cases for each drug alone as well as for all six drugs, as reported previously. 17,18,19 A national survey in china showed the rates for MDR-TB in new and previously treated cases were 5.7% and 25.6%, respectively. 17 In our study 19% of patients are mono-drug resistant and 18% patients have MDR-TB.…”

Section: Discussionmentioning

confidence: 99%

Socio-demographic Profile and Drug Sensitivity Pattern of Suspected Drug Resistant Tuberculosis among Patients in Regional Tuberculosis Reference Laboratory (R.T.R.L) of a Tertiary Hospital

et al. 2017

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ound: ound: Drug resistant tuberculosis has been reported in all regions of the world. In this study we address the socio-demographic profile and drug sensitivity pattern as well as prevalence of drug resistance tuberculosis in a tertiary center (regional TB reference laboratory) in Bangladesh. (64) were between 15-45 years with poor socio economic condition (73%) and primarily educated. Analysis of our Study result showed that 18% of patients were mono-drug resistant. Among them 13% showed resistance to isoniazid (INH), 4% to streptomycin and only 2% to rifampicin. No patient was found resistant to pyrazinamide (PNZ) and 38% of patient with suspected drug -resistant TB was found to have no drug resistance. 18% of patient had multidrug resistant tuberculosis (MDR-TB) among which 56% were relapse cases (48% after cat -I, 8% after cat II), 24% were non -converter of cat -I, 12% belonged to failure of cat -I, 3% failure of cat -II, 2% return after default and others. 1% of patient had history of contact with MDR -TB patient.

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Drug Resistance Pattern of Mycobacterium Tuberculosis Complex at a Medical Center in Central Taiwan, 2003–2007

Cited by 14 publications

References 14 publications

Drug Susceptibility Patterns of Mycobacterium tuberculosis Isolated from Patients with Pulmonary Tuberculosis in Tripoli-Libya

Drug Susceptibility Patterns of Mycobacterium tuberculosis Isolated from Patients with Pulmonary Tuberculosis in Tripoli-Libya

Rates and risk factors for drug resistance tuberculosis in Northeastern China

Socio-demographic Profile and Drug Sensitivity Pattern of Suspected Drug Resistant Tuberculosis among Patients in Regional Tuberculosis Reference Laboratory (R.T.R.L) of a Tertiary Hospital

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