Drug-resistant Diarrheogenic<i>Escherichia coli</i>, Mexico

Estrada-García, Teresa; Cerna, Jorge F.; Paheco-Gil, Leova; Velázquez, Raúl F.; Ochoa, Theresa J.; Torres, Javier; DuPont, Herbert L.

doi:10.3201/eid1108.050192

Cited by 90 publications

(86 citation statements)

References 13 publications

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“…Another report from northern Iran (2014) showed that 79.4% of the isolated E. coli were resistant to cefixime (30). Studies from Peru, Vietnam, Brazil and Mexico have also reported greater resistance to ampicillin in E. coli (31)(32)(33)(34). Our findings are similar to those of the studies from Iran, Peru, Vietnam, Brazil and Mexico (29)(30)(31)(32)(33)(34).…”

Section: Discussionsupporting

confidence: 82%

“…Studies from Peru, Vietnam, Brazil and Mexico have also reported greater resistance to ampicillin in E. coli (31)(32)(33)(34). Our findings are similar to those of the studies from Iran, Peru, Vietnam, Brazil and Mexico (29)(30)(31)(32)(33)(34). It should be also noted that in many cases, antibiotic resistance is transmitted to humans, hospitalized patients and the hospital environment through other sources, including food plants, animals, fish, poultries, and other industries, in which antibiotics are used for different purposes and may lead to the emergence of resistant strains (35)(36)(37)(38).…”

Section: Discussionmentioning

confidence: 99%

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Molecular Detection of Diffusely Adherent Escherichia coli Strains Associated with Diarrhea in Shiraz, Iran

Abbasi

Kargar

Doosti

et al. 2016

Arch Pediatr Infect Dis

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Molecular Detection of Diffusely Adherent Escherichia coli Strains Associated with Diarrhea in Shiraz, Iran

Abbasi

Kargar

Doosti

et al. 2016

Arch Pediatr Infect Dis

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“…In the current study, as in many reports, the resistance rates of ampicillin, cotrimoxazole (trimethoprim-sulfamethoxazole) and tetracycline antibiotics were high and more than 39 % of the isolates showed resistance to these antibiotics (Putnam et al, 2004;Estrada-García et al, 2005;Nguyen et al, 2005). Resistance rates of EPEC to different antibiotics, however, differ noticeably between countries (Putnam et al, 2004;Estrada-García et al, 2005;Diniz-Santos et al, 2006;Nguyen et al, 2006;Pérez et al, 2010), which may reflect differences in the effectiveness of antimicrobial stewardship programs.…”

Section: Discussionmentioning

confidence: 56%

Molecular analysis of typical and atypical enteropathogenic Escherichia coli (EPEC) isolated from children with diarrhoea

Nakhjavani

Emaneini

Hosseini

et al. 2013

Journal of Medical Microbiology

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Diarrhoea continues to be one of the most common causes of morbidity and mortality among infants and children in developing countries. To investigate the incidence, antimicrobial resistance and genetic relationships of enteropathogenic Escherichia coli (EPEC) in children with diarrhoea, a total of 612 stool specimens were collected in Tehran, Iran, and cultured to isolate strains of EPEC. The disc diffusion method was used to determine the susceptibility of the isolates according to the Clinical and Laboratory Standards Institute (CLSI) guidelines. The presence of eae, stx and bfp-A genes was determined by PCR. The genetic relationships between EPEC isolates were determined by pulsed-field gel electrophoresis (PFGE). Out of the 412 strains of E. coli obtained from 612 diarrhoeal stool specimens, 23 (5.6 %) were identified as EPEC, of which seven (30.4 %) were classified as typical strains of EPEC and 16 (69.6 %) were classified as atypical. Out of the 23 EPEC isolates, 69.5 % were resistant to ampicillin, 39.1 % were resistant to tetracycline and cotrimoxazole, 30.4 % were resistant to cefpodoxime, ceftazidime, ceftriaxone and aztreonam, and 26.1 % were resistant to imipenem. The isolates were classified into 21 pulsotypes by PFGE profiles. The present study shows that typical and atypical EPEC isolates displayed considerable heterogeneity in PFGE profiles and EPEC infections were only sporadic in Tehran. Overall 69 % of isolates were resistant to at least one of the antibiotics tested. INTRODUCTIONEnteropathogenic Escherichia coli (EPEC) is one of the major causes of diarrhoea among children in developing countries (Hernandes et al., 2009;Moura et al., 2009). The pathogenesis of EPEC depends on the locus of enterocyte effacement (LEE), a chromosomal pathogenicity island. The LEE contains a number of different genes, including eae, which has an essential role in inducing a characteristic lesion formation in the intestinal epithelium, termed an attaching and effacing (A/E) lesion (Elliott et al., 1998;Vallance & Finlay 2000;Kaper et al., 2004). The eae gene encodes intimin, a 94 kDa outer-membrane protein that is responsible for the intimate adherence between bacterial and enterocyte membranes (Vallance & Finlay, 2000;Trabulsi et al., 2002). EPEC strains are classified as typical or atypical, according to the presence or absence of the E. coli adherence factor plasmid (EAF) that carries the bfpA gene, which encodes the bundle-forming pili (Hernandes et al., 2009). The most typical EPEC strains belong to the classic O : H serotypes and are eae-and bfpA-positive (Ochoa et al., 2008). The atypical EPEC isolates are eaepositive and bfpA-and stx (the gene encoding shiga-like toxin)-negative. EPEC are among the most important pathogens infecting children under 2 years of age in the developing world (Ochoa et al., 2008). Recent studies indicate that atypical EPEC is more prevalent than typical Abbreviations: EPEC, enteropathogenic Escherichia coli; LEE, locus of enterocyte effacement; PFGE, pulsed-field gel electrophore...

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“…Clinical isolates of diarrheogenic E. coli have high levels of multidrug resistance in previous studies (Estrada-Garcia et al 2005). E. coli can induce persistent diarrhea that has been associated with malnutrition, growth impairment, and death in developing countries (Nataro and Kaper 1998).…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity of Dipeptide Constructs of Acetylsalicylic Acid and Nicotinic Acid

Bartzatt¹,

Cirillo

2007

Drug Delivery

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Drug-resistant DiarrheogenicEscherichia coli, Mexico

Cited by 90 publications

References 13 publications

Molecular Detection of Diffusely Adherent Escherichia coli Strains Associated with Diarrhea in Shiraz, Iran

Molecular Detection of Diffusely Adherent Escherichia coli Strains Associated with Diarrhea in Shiraz, Iran

Molecular analysis of typical and atypical enteropathogenic Escherichia coli (EPEC) isolated from children with diarrhoea

Antibacterial Activity of Dipeptide Constructs of Acetylsalicylic Acid and Nicotinic Acid

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