2005
DOI: 10.1001/jama.293.22.2726
|View full text |Cite
|
Sign up to set email alerts
|

Drug-Resistant Tuberculosis, Clinical Virulence, and the Dominance of the Beijing Strain Family in Russia

Abstract: Context Tuberculosis and multidrug-resistant tuberculosis is a serious public health problem in Russia.Objective To address the extent of "Beijing strain" transmission in the prison/civil sectors and the association of drug resistance, clinical, and social factors with the Beijing genotype. Design and SettingCross-sectional population-based molecular epidemiological study of all civilian and penitentiary tuberculosis facilities in the Samara region, Russia. Patients Consecutively recruited patients with bacter… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

26
155
7
11

Year Published

2005
2005
2011
2011

Publication Types

Select...
7
3

Relationship

0
10

Authors

Journals

citations
Cited by 204 publications
(199 citation statements)
references
References 23 publications
26
155
7
11
Order By: Relevance
“…The SIT1 spoligotype is characteristic of the Beijing/W family, which is known for its frequent association with MDR, outbreaks and high emergence worldwide. The prevalence of Beijing isolates in Russia, both in prisons and in the community, and the high rate of MDR typical for this group have been recognized in a number of studies [5,6,23,[25][26][27]. Our results are consistent with this observation and demonstrate that the Beijing genotype plays an important role in the epidemiology of MDR-TB in civilian population of this high incidence region of the North-Western Russia.…”
Section: Resultssupporting
confidence: 90%
“…The SIT1 spoligotype is characteristic of the Beijing/W family, which is known for its frequent association with MDR, outbreaks and high emergence worldwide. The prevalence of Beijing isolates in Russia, both in prisons and in the community, and the high rate of MDR typical for this group have been recognized in a number of studies [5,6,23,[25][26][27]. Our results are consistent with this observation and demonstrate that the Beijing genotype plays an important role in the epidemiology of MDR-TB in civilian population of this high incidence region of the North-Western Russia.…”
Section: Resultssupporting
confidence: 90%
“…This is a matter of concern considering the rapid global spread and suspected association of these genotypes with high virulence Drobniewski et al, 2005).…”
Section: Discussionmentioning
confidence: 99%
“…The need for antitubercular drugs with novel mechanisms of action has been heightened by the emergence of multi-drug resistant and extensively drug-resistant strains of M. tuberculosis, particularly in Africa and Eastern European countries [23][24][25][26]. Nucleoside analogs would complement the antitubercular drug arsenal because the mechanism of action employed by these compounds differs enough from existing antitubercular drugs that cross-resistance should be avoided.…”
Section: Introductionmentioning
confidence: 99%