Drug screening strategies using metal-based luminescent probes

Li, Guodong; Wu, Cheng‐Shyong; Ma, Dik‐Lung; Leung, Chung‐Hang

doi:10.1016/j.trac.2021.116270

Cited by 18 publications

(9 citation statements)

References 147 publications

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“…Upon decaying to the ground state, long‐lived luminescence with lifetimes of microsecond to millisecond scales (much longer than those of organic interferent fluorophores) is generated. [ 13 ] For example, Yang et al reported a NIR‐II lanthanide complex Nd‐DOTA with a lifetime of 5.37 μs at 1060 nm and NIR‐II emission wavelength caused by 4 F 3/2 → 4 I 11/2 transition. [ 22 ] Notably, these long‐lived lanthanides have typical energy levels with characteristic absorption band and emission in the NIR‐II region (Figure 2C), which are favorable for bioimaging and biosensing when integrated with time‐resolved luminescence techniques.…”

Section: Long‐lived Nir‐ii Luminescent Probesmentioning

confidence: 99%

Long‐Lived Second Near‐Infrared Luminescent Probes: An Emerging Role in Time‐Resolved Luminescence Bioimaging and Biosensing

Feng

Ko³

et al. 2022

Small Structures

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Luminescence bioimaging and biosensing in the second near‐infrared (NIR‐II) spectral window (1,000–1,700 nm wavelengths) is a newly emerging technique that is extensively used in fundamental research and clinical practice. Owing to its advantages, including deep tissue penetration and excellent temporal resolution, this technique has shown tremendous promise for target‐specific imaging and noninvasive monitoring. However, developing bioimaging modalities that enable target‐specific imaging with high resolution and sensitivity remains a great challenge today. Compared with NIR‐II fluorescence imaging, NIR‐II luminescence lifetime imaging with advantages such as lower background noises, higher sensitivity, and higher spatial resolution has opened up new avenues for deep tissue imaging and biomedical applications. Herein, various types of long‐lived NIR‐II luminescent probes, including complex dyes, rare‐earth‐doped nanoparticles, organic compound‐loaded nanoparticles, inorganic‐based dots and nanotubes, as well as the main types of time‐resolved luminescence techniques including time‐domain (e.g., time‐correlated single‐photon counting, time‐gated detection, pulse sampling, etc.) and frequency‐domain systems are first summarized. The unique advantages of long‐lived NIR‐II luminescent probes and their critical roles in bioimaging and biosensing are also highlighted. Finally, the present challenges and future directions of long‐lived NIR‐II luminescent probes in biomedical research, translational research, and (pre‐)clinical studies are discussed.

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Section: Long‐lived Nir‐ii Luminescent Probesmentioning

confidence: 99%

Long‐Lived Second Near‐Infrared Luminescent Probes: An Emerging Role in Time‐Resolved Luminescence Bioimaging and Biosensing

Feng

Ko³

et al. 2022

Small Structures

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“…Luminescent metal complexes, especially iridium(III) complexes, have been employed to detect a range of species due to their high photostability, large Stokes shift, selective luminescence enhancement in the presence of G-quadruplex DNA, and long-lived emission that allows discrimination from fluorescence noise in biological matrices by use of time-resolved techniques [20] , [21] , [22] , [23] , [24] . Our previous studies have demonstrated that iridium(III) complex-based interference reduction biosensing strategies, such as nicking endonuclease-mediated interference reduction rolling circle amplification (NEM-IR-RCA) and interference reduction nucleic acid amplification strategy (IR-NAAS), are suitable for the highly specific detection of target nucleic acid sequences, such as miRNAs and COVID-19 RNAs [18] , [25] .…”

Section: Introductionmentioning

confidence: 99%

Interference reduction isothermal nucleic acid amplification strategy for COVID-19 variant detection

Wang

et al. 2023

Sensors and Actuators B: Chemical

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“…In order to overcome limitations associated with these large-scale instrumental methods (e.g., expense and time-consumption), various in situ rapid detection techniques, based on colorimetric, fluorescence, surface-enhanced Raman spectroscopy (SERS) and electrochemical detection, have been developed. [24][25][26] Rates of reactions involved in colorimetric and fluorescence analysis are normally controlled by the reactant concentration and diffusion, which can be accelerated by using solid catalysts. SERS analysis is primarily performed on substrates with precise delivery of analytes onto SERS hot spots.…”

Section: Introductionmentioning

confidence: 99%