Drug substance manufacture process control: application of flow injection analysis and HPLC for monitoring an enantiospecific synthesis

Chong, Kwok Feng; Loughlin, Thomas; Moeder, Charles; Perpall, Holly J.; Thompson, Richard A.; Grinberg, Nelu; Smith, George B.; Bhupathy, M.; Bicker, G.

doi:10.1016/0731-7085(96)01810-9

Cited by 6 publications

(4 citation statements)

References 27 publications

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“…Such a remote chiral center renders interactions with the brush type chiral stationary phases unlikely. 54 The difference between the two compounds stems from the two fluorine atoms in L-708,738, compared to the chlorine atom linked to the quinoline moiety in MK0476. Thus, MK0476 is expected to be more apolar of the two compounds because of the presence of the highly electronegative fluorine atoms in L-708,738.…”

Section: Resultsmentioning

confidence: 99%

Mechanistic aspects of chiral discrimination by surface-immobilized ?1-acid glycoprotein

et al. 1999

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Section: Resultsmentioning

confidence: 99%

Mechanistic aspects of chiral discrimination by surface-immobilized ?1-acid glycoprotein

et al. 1999

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“…The phosphorylation stage is mostly executed with POCl3 in pyridine, and the selectively exposed 6-OH group included the triethylsilyl (TES) protecting group. The movement of the leaving groups was achived in late 2-step, thisenhancement of selectivity for producing phosphate group in sugaramine-6-OH [48][49][50].…”

Section: Biocatalytic Potential Of Enzymes Involved the Modification Of Glucosamine In Chemotherapeuticalmentioning

confidence: 99%

Biocatalytic Potential of Enzymes Involved the Modification of Glucosamine in Chemotherapeutical Intermediates Synthesis

Senan¹

2021

J Food Chem Nanotechnol

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The enzymatic modification of glucosamine (GlcN) and its derivatives have a keen interest for researchers due to the natural abundance of its bio-sourced such as chitin. The recent progress for understanding the role of glucosamine based on various novel approaches for enzymatic synthesis in the field of medicinal chemistry and food supplements. These developments led to improve chemo-selective protection and/or deprotection of amino-sugar during chainenhancement and allow the simultaneous regioselective reaction of functionally relevant acetyl, phosphate, or sulfate groups. In this review, we give an overview of current strategies on the synthesis of therapeutically relevant glucosaminecontaining derivatives.

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“…In this respect Flow Injection Analysis (FIA) shows great potential for connecting chromatographic techniques to processes. Coupling of FIA to both HPLC and CE has been described previously [1,2]. The application to industrial process control seems to be possible but not often been reported.…”

Section: Introductionmentioning

confidence: 97%

Flow injection analysis coupled with HPLC and CE for monitoring chemical production processes

Dantan

Frenzel

Küppers³

2001

Chromatographia

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Drug substance manufacture process control: application of flow injection analysis and HPLC for monitoring an enantiospecific synthesis

Cited by 6 publications

References 27 publications

Mechanistic aspects of chiral discrimination by surface-immobilized ?1-acid glycoprotein

Mechanistic aspects of chiral discrimination by surface-immobilized ?1-acid glycoprotein

Biocatalytic Potential of Enzymes Involved the Modification of Glucosamine in Chemotherapeutical Intermediates Synthesis

Flow injection analysis coupled with HPLC and CE for monitoring chemical production processes

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