Drug use and childhood-, military- and post-military trauma exposure among women and men veterans

Kelley, Michelle L.; Brancu, Mira; Robbins, Allison T.; D'Lima, Gabrielle M.; Strauss, Jennifer; Curry, John F.; Fairbank, John A.; Runnals, Jennifer J.

doi:10.1016/j.drugalcdep.2015.03.038

Cited by 13 publications

(9 citation statements)

References 58 publications

(89 reference statements)

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“…The positive effects of psychotherapy can be circumvented by binge alcohol abuse, 39 , 40 , 41 which is more common in individuals with PTSD compared with the general population (60–80% of PTSD patients). 42 , 43 , 44 It may be possible to improve the efficiency of desensitization through the use of selective AMPAR antagonists provided during critical intervals of desensitization therapy.…”

Section: Discussionmentioning

confidence: 99%

Hippocampal encoding of interoceptive context during fear conditioning

Yoo

Tovar‐y‐Romo

et al. 2017

Transl Psychiatry

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Rodent models of auditory fear conditioning are often used to understand the molecular mechanisms regulating fear- and anxiety-related behaviors. Conditioning and extinction memories are influenced by contextual cues, and the reinstatement of conditioned fear occurs when the conditioning stimulus is presented in a context different from the extinction context. Although it has been proposed that internal state is a feature of context that could influence extinction, contributions of interoception to conditioning have not been experimentally addressed. Here we use ethanol (EtOH) to show that interoceptive cues are encoded through the hippocampus by mechanisms that involve increased phosphorylation of GluR1 on serine 845, and biophysical alterations in neuronal membranes that facilitate stabilization of surface-located calcium-permeable n-2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl) propanoic acid (AMPA) receptor (AMPAR) into membrane microdomains. Conflicting interoceptive cues during extinction and fear relapse testing resulted in a failure to consolidate extinction that was reversed by the administration of AMPAR antagonists immediately following the retrieval cue.

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Section: Discussionmentioning

confidence: 99%

Hippocampal encoding of interoceptive context during fear conditioning

Yoo

Tovar‐y‐Romo

et al. 2017

Transl Psychiatry

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“…Furthermore, MDD usually followed the onset of other comorbid disorders among women veterans, indicating the need to assess for earlier lifetime disorders in veterans with MDD. Runnals et al, 2013 Women were more likely to endorse back pain and headaches than men. See pain section earlier. Kelley et al, 2013; Kelley et al, 2015 PTSD symptoms were found to mediate the effects of trauma exposure on alcohol differently for men and women. See substance use section earlier. Schry et al, 2015 Male veterans who reported MSA (the most egregious form of military sexual trauma experiences, involving force or penetration) endorsed higher levels of Department of Veterans Affairs (VA) service-connected disability, recent outpatient mental-health treatment utilization, PTSD symptoms, depression symptoms, and suicidality than the general OEF/OIF sample without MSA.…”

Section: Table A1mentioning

confidence: 97%

“…The distress factor in particular was significant for suicidality and suicide attempts. Vulnerability: Youssef et al, 2013a Childhood trauma exposures were found to be associated with depressive symptoms and suicidal ideation. Violence Elbogen et al, 2010 Aggressive impulses or urges, difficulty managing anger, and perceived problems controlling violent behavior were each significantly associated with PTSD hyperarousal symptoms. Substance use Smoking: Calhoun et al, 2011; McClernon et al, 2013 PTSD symptoms affected the expectancies veterans had regarding the benefits of smoking, including beliefs that smoking could reduce negative affect and boredom or increase social facilitation (Calhoun et al, 2011). The risk of smoking increased as a function of the number of comorbid psychiatric illnesses with similar reported expectancies (McClernon et al, 2013) suggesting that both PTSD as well as co-occurring psychiatric conditions affect smoking habits. Alcohol and other drug use: Kelley et al, 2013; Kelley et al, 2015 Depressive symptoms significantly mediated the effects of combat and noncombat exposure on both alcohol and drug use. Similarly, PTSD symptoms served as a similar mediator between trauma exposure and alcohol, but only for men and not for other drug use.…”

Section: Table A1mentioning

confidence: 99%

The Post‐Deployment Mental Health (PDMH) study and repository: A multi‐site study of US Afghanistan and Iraq era veterans

Brancu

Wagner

Morey

et al. 2017

Int J Methods Psych Res

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The United States (US) Department of Veterans Affairs (VA) Mid-Atlantic Mental Illness Research, Education, and Clinical Center (MIRECC) Post-Deployment Mental Health (PDMH) multi-site study examines post-deployment mental health in US military Afghanistan/Iraq-era veterans. The study includes the comprehensive behavioral health characterization of over 3600 study participants and the genetic, metabolomic, neurocognitive, and neuroimaging data for many of the participants. The study design also incorporates an infrastructure for a data repository to re-contact participants for follow-up studies. The overwhelming majority (94%) of participants consented to be re-contacted for future studies, and our recently completed feasibility study indicates that 73-83% of these participants could be reached successfully for enrollment into longitudinal follow-up investigations. Longitudinal concurrent cohort follow-up studies will be conducted (5-10+ years post-baseline) to examine predictors of illness chronicity, resilience, recovery, functional outcome, and other variables, and will include neuroimaging, genetic/epigenetic, serum biomarker, and neurocognitive studies, among others. To date, the PDMH study has generated more than 35 publications from the baseline data and the repository has been leveraged in over 20 publications from follow-up studies drawing from this cohort. Limitations that may affect data collection for a longitudinal follow-up study are also presented.

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“…2, the literature cited by this cluster was largely concentrated in the period between 2007 and 2014, a fairly long time span, which means that research on post-deployment symptoms has been a key field in military health and medicine research in the past 10 years [19]. With the analysis of reference co-citation network mapping, the cluster for post-deployment symptoms was found to have several nodes that are closely related to Cluster #3, in addition to the strong link with Cluster #0 [2, 20]. …”

Section: Discussionmentioning

confidence: 99%

Knowledge mapping visualization analysis of the military health and medicine papers published in the web of science over the past 10 years

Zhang

Luo

et al. 2017

Military Med Res

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BackgroundMilitary medicine is a research field that seeks to solve the medical problems that occur in modern war conditions based on public medicine theory.MethodsWe explore the main research topics of military health and medical research in the web of science™ core collection (WoSCC) from 2007 to 2016, and the goal of this work is to serve as a reference for orientation and development in military health and medicine. Based on CiteSpace III, a reference co-citation analysis is performed for 7921 papers published in the WoSCC from 2007 to 2016. In addition, a cluster analysis of research topics is performed with a comprehensive analysis of high-yield authors, outstanding research institutions and their cooperative networks.ResultsCurrently, the research topics in military health and medicine mainly focus on the following seven aspects: mental health diagnoses and interventions, an army study to assess risk and resilience in service members (STARRS), large-scale military action, brain science, veterans, soldier parents and children of wartime, and wound infection. We also observed that the annual publication rate increased with time. Wessely S, Greenberg N, Fear NT, Smith TC, Smith B, Jones N, Ryan MAK, Boyko EJ, Hull L, and Rona RJ were the top 10 authors in military health and medicine research. The top 10 institutes were the Uniformed Services University of the Health Sciences, the United States Army, the United States Navy, Kings College London, Walter Reed National Military Medical Center, Boston University, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Naval Health Research Center, and the VA Boston Healthcare System.ConclusionsWe are able to perform a comprehensive analysis of studies in military health and medicine research and summarize the current research climate and the developmental trends in the WoSCC. However, further studies and collaborations are needed worldwide. Overall, our findings provide valuable information and new perspectives and shape future research directions for further research in the area of military health and medicine.

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Drug use and childhood-, military- and post-military trauma exposure among women and men veterans

Cited by 13 publications

References 58 publications

Hippocampal encoding of interoceptive context during fear conditioning

Hippocampal encoding of interoceptive context during fear conditioning

The Post‐Deployment Mental Health (PDMH) study and repository: A multi‐site study of US Afghanistan and Iraq era veterans

Knowledge mapping visualization analysis of the military health and medicine papers published in the web of science over the past 10 years

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