Drug use by Brazilian students: associations with family, psychosocial, health, demographic and behavioral characteristics

Micheli, Denise De; Formigoni, Maria Lucia Oliveira Souza

doi:10.1111/j.1360-0443.2003.00671.x

Cited by 88 publications

(84 citation statements)

References 26 publications

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“…Second, although there is detailed epidemiological data in some countries about the patterns of ecstasy use among high school and middle school students [38,44,67], information on the prevalence of ecstasy use at other ages and among certain high risk groups, is inadequate. Some women report ecstasy use during pregnancy [64] and MDMA has been detected in meconium [117], albeit infrequently.…”

Section: Discussionmentioning

confidence: 99%

“…More adolescent boys than girls try ecstasy [38,82,136] and this pattern typically continues into adulthood [78]. Women that received equivalent MDMA doses (on a mg/kg basis) as men in a research environment rated their acute subjective experiences, both positive and negative, as more intense then men.…”

Section: Sex-differencesmentioning

confidence: 99%

“…Future pharmacodynamic avenues to continue to pursue will be how ontogeny influences free radical generation [28] and regulation in response to MDMA. Similarly, the dynamic changes in postsynaptic monoamine receptor levels are also likely contributors to the differential sensitivity to the physiological and behavioral effects of MDMA.Second, although there is detailed epidemiological data in some countries about the patterns of ecstasy use among high school and middle school students [38,44,67], information on the prevalence of ecstasy use at other ages and among certain high risk groups, is inadequate. Some women report ecstasy use during pregnancy [64] and MDMA has been detected in meconium [117], albeit infrequently.…”

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confidence: 99%

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A developmental comparison of the neurobehavioral effects of ecstasy (MDMA)

Piper

2007

Neurotoxicology and Teratology

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The entactogen ±3,4-methylenedioxymethamphetamine (MDMA or ecstasy) is a popular recreational drug among college, high school, and, occasionally, middle school students. Preclinical research examining the acute and long-term effects of MDMA has predominately been conducted in reproductively mature subjects but there has been increasing interest in adolescent and in utero exposure. This review examines the acute and long-term responses to MDMA during perinatal, adolescent, and adult periods. The ability of MDMA to alter core body temperature emerges gradually during ontogeny while a reduction in body weight is evident at all ages. Learning and workingmemory are also altered independent of the developmental stage of exposure. Current evidence suggests adults are more sensitive to the long-term serotonin depletions following MDMA but younger ages also exhibit substantial and rapid neuroplasticity. Sexually dimorphic MDMA responses have been identified for the acute hyperthermic and motoric effects of MDMA with pubescent males being especially susceptible. Several physiological, behavioral, and neurochemical MDMA issues requiring further study are also outlined. Keywords±3; 4-methylenedioxymethamphetamine; Adolescence; Anxiety; Depression; Learning; SerotoninThe phenylethylamine ±3,4-methylenedioxymethamphetamine (MDMA) is a popular recreational drug best known as ecstasy. MDMA has several other street names including Adam, baby slits, chocolate chips, clarity, doctor, essence, kleenex, and roll [77]. Although ecstasy has some similarities with both stimulants and hallucinogens, MDMA is an entactogen. Entactogen means "touching within" based on the drug's subjective effects [110]. MDMA also causes long term changes in several markers of the integrity of the serotonin (5-HT) neurotransmitter system [58]. There have been several excellent recent reviews on MDMA toxicology, pharmacokinetics, pharmacodynamics, and neurobehavioral consequences [30,37,113,157], but none have systematically addressed the intricate effects of MDMA during development.Ecstasy use is not restricted to limited subpopulations, that is fans of techno music and "raves" [173] or male homosexuals [73,81], as MDMA has expanded into the general population [124,148,170] and especially young people [52,78,170,172]. Over one hundred pregnant women in Toronto called a substance abuse helpline between 1998 and 2000 to inquire Corresponding Author: Brian J. Piper, Neuroscience and Behavior Program, University of Massachusetts, Amherst, MA 01003-7710, Tel: (413) 545-0996, bpiper@nsm.umass.edu Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers...

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Section: Discussionmentioning

confidence: 99%

Section: Sex-differencesmentioning

confidence: 99%

mentioning

confidence: 99%

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A developmental comparison of the neurobehavioral effects of ecstasy (MDMA)

Piper

2007

Neurotoxicology and Teratology

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“…Um dos poucos estudos brasileiros que aborda o tema da família de adolescentes usuários de drogas é o estudo de De Micheli e Formigoni 31 . Para estas autoras, a família possui um papel crucial na dependência de drogas na adolescência e pouco monitoramento e cuidados por parte dos pais estão associados à dependência de drogas nessa população.…”

Section: Estilo Parentalunclassified

Aspectos familiares de meninas adolescentes dependentes de álcool e drogas

Guimarães¹,

Hochgraf²,

Brasiliano³

et al. 2009

Rev. psiquiatr. clín.

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“…Inhalant use-related problems affect youths worldwide, particularly socioeconomically disadvantaged children and adolescents (De Micheli and Formigoni, 2004;Kozel et al, 1995;Pagare et al, 2004;Tapia-Conyer et al, 1995). Second only to marijuana, inhalants constitute the illicit drug most likely to be used by American youths (Johnston et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Inhalant use and disorders among adults in the United States

Wu¹,

Ringwalt²

2006

Drug and Alcohol Dependence

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Objective-To examine the patterns of adult inhalant use and correlates of inhalant use disorder.Method-We drew study data from the 2002 and 2003 National Surveys on Drug Use and Health (NSDUH). We used logistic regression to identify the characteristics associated both with inhalant use and inhalant use disorder.Results-One in ten of all adults had used an inhalant at least once in their lives, and 0.5% used one in the past year. Among all past year inhalant users, 8% met the criteria for an inhalant use disorder (i.e., 6.6% for abuse and 1.1% for dependence) within that period. We found an increased prevalence of past year inhalant use among young adults aged 18-25, Asians, past year alcohol abusers and dependents, lifetime drug users, white women, and men reporting symptoms of serious mental illness. Inhalant-using adults who met the criteria for an inhalant use disorder were predominantly adults aged 35-49 and were less educated, had received recent professional treatment for emotional or psychological problems, used inhalants weekly, and had a coexisting alcohol use disorder. Conclusion-The patterns and consequences of adult inhalant use differ from those of adolescents. Compared with adolescent inhalant users, adult users tend not to initiate inhalant use until adulthood, use inhalants less frequently, use fewer inhalants, and are less likely to engage in criminal activities.

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Drug use by Brazilian students: associations with family, psychosocial, health, demographic and behavioral characteristics

Abstract: The findings suggest that preventive programmes should be more comprehensive in scope, rather than focusing only on information about the negative consequences of drug use.

Cited by 88 publications

References 26 publications

A developmental comparison of the neurobehavioral effects of ecstasy (MDMA)

A developmental comparison of the neurobehavioral effects of ecstasy (MDMA)

Aspectos familiares de meninas adolescentes dependentes de álcool e drogas

Inhalant use and disorders among adults in the United States

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