Drug user behavior about the development and rehabilitation process in Banda Aceh correctional institution

Alamsyah, Trian Pamungkas; Marianthi, Dewi; Hayati, Wirda; Usrina, Nora

doi:10.31295/ijhms.v4n1.1348

Cited by 5 publications

(5 citation statements)

References 8 publications

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“…This is a serious limitation. b. Ligand is a molecule that binds a central metal atom to form a coordination complex [3]. The number of known ligands is very less due to which the applicability of the Ligand-based methods is very less.…”

Section: Disadvantages Of the Traditional Computing Methodsmentioning

confidence: 99%

novel algorithm for predicting adverse drug-drug interaction

Savitha

Rani

2022

ijhs

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Molecules are the fundamental units of any chemical compound. A drug is a predefined composition of chemical compounds which is expected to produce a target biological behavior. Drug error is a term used to indicate a scenario where one drug increases or decreases the effect of another drug when both are present inside the human body. This may be either due to pharmacodynamics (effect or action of a drug) or pharmacokinetics (movement of a drug within the body) or both. The results are painful as a person can suffer from serious disability or health hazard. The problem is mainly due to human error while prescribing and lack of efficient systems that can aid in automatic diagnosis of interacting drugs. Most of the issues that a patient undergoes or becomes a victim due to polypharmacy can be avoided and prevented. What we lack is an intelligent system that can predict the adverse interaction of poly drugs and raise an alarm to the medical team. This can be a live saver. This paper attempts to propose a model based on machine learning that can predict adverse drug-drug interaction.

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Section: Disadvantages Of the Traditional Computing Methodsmentioning

confidence: 99%

novel algorithm for predicting adverse drug-drug interaction

Savitha

Rani

2022

ijhs

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“…(1) Skin also has ability to absorb the topically applied ingredients and hence the acceptance of skin as ideal route is increasing for delivering variety of drug molecules. (2) The structure of skin assists the topically applied ingredients to reach the various layers of skin as well as to reach the systemic circulation. Most of the ingredients penetrate the skin through three major pathways i.e.…”

Section: Introductionmentioning

confidence: 99%

Emulgel: A revolution in topical drug delivery system

Ahmed

Verma

Khan

et al. 2022

ijhs

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Topical delivery of drugs is one of the ideal routes of administrating a wide range of drug candidates and emulgels are emerging as a novel formulation, which exhibited the characteristics of both the emulsions and gels. Emulgel demonstrated improved penetrability during several studies and it is able to deliver hydrophilic as well as hydrophobic drugs and hence overcome the limitations of traditionally available topical preparations. More stable and effective emulgels can be prepared by nanonizing and micronizing the globules of emulsions, which improves the stability and half-life of Emulgels. The commercial availability along with the presence of strong clinical pipeline of emulgels is indicating towards the acceptance of this formulation while several advantages associated with this approach is also suggesting towards its potential as ideal topical drug delivery system. This article enlisted in-depth information about the emulgels, its components and structure along with the general method of production, evaluation and future scenario of this approach. The article also involved information about the patents insight, commercially available products and previously used drugs for developing stable emulgels.

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“…[3] There is strong evidence that the mechanism leading to basal cell damage is a cell-mediated immune process involving T lymphocytes with cytotoxic activity against the epithelial cell. [3,4] The diagnosis of OLP should be based on the modified World Health Organisation(WHO) criteria proposed by Van der Meij and Van der Waal in 2003. [5] OLP has a documented risk for malignant transformation.…”

Section: Introductionmentioning

confidence: 99%

p53 Polymorphism in Oral Lichen Planus

Vijayan

Muthukrishnan

2022

ijhs

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Oral lichen planus (OLP) is a chronic relapsing inflammatory disease. It involves T-lymphocyte aggression targeted to the basal layer of the oral mucosa.p53 plays a central role in the prevention of normal cells from the development of the malignant phenotype. Somatic alterations in p53 cause defects in normal p53 function. Wild type p53 plays an important role in repairable damage of the cell due to cellular stresses. Over-expression, as well as polymorphic variants of Mouse double minute 2(MDM2), have effects on p53 disturbances. In addition, degradation of p53 by E6 protein of high-risk human papillomavirus is also suggested as one of the mechanisms which attenuate p53 responses in oral carcinogenesis. Polymorphisms in p53 are anticipated to cause measurable disturbance in p53 function. Polymorphism of the codon 72 on exon 4 of the gene p53 is the first and most commonly known polymorphism of this gene. The presence of p53 has been demonstrated as an early marker of dysplasia in Oral Potentially Malignant Disorders. This review discusses about p53 polymorphism as an early indicator of genetic predisposition to neoplastic transformation in OLP.

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Drug user behavior about the development and rehabilitation process in Banda Aceh correctional institution

Cited by 5 publications

References 8 publications

novel algorithm for predicting adverse drug-drug interaction

novel algorithm for predicting adverse drug-drug interaction

Emulgel: A revolution in topical drug delivery system

p53 Polymorphism in Oral Lichen Planus

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