2014
DOI: 10.3390/polym6030799
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Drugs and Polymers for Delivery Systems in OA Joints: Clinical Needs and Opportunities

Abstract: Osteoarthritis (OA) is a big burden of disease worldwide and one of the most common causes of disability in the adult population. Currently applied therapies consist of physical therapy, oral medication, intra-articular injections, and surgical interventions, with the main goal being to reduce pain and improve function and quality of life. Intra-articular (IA) administration of drugs has potential benefits in OA treatment because it minimizes systemic bioavailability and side effects associated with oral admin… Show more

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Cited by 42 publications
(30 citation statements)
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“…Therefore, even if MTX were available to treat a chronic disease like OA, there would be serious concerns about its safety aspects. Moreover, an oral treatment such as MTX is not appropriate to treat OA, which is usually regarded as a localized disease, for which the optimal treatment is a therapy applied directly to the affected joint [ 17 , 18 ].…”
Section: Introductionmentioning
confidence: 99%
“…Therefore, even if MTX were available to treat a chronic disease like OA, there would be serious concerns about its safety aspects. Moreover, an oral treatment such as MTX is not appropriate to treat OA, which is usually regarded as a localized disease, for which the optimal treatment is a therapy applied directly to the affected joint [ 17 , 18 ].…”
Section: Introductionmentioning
confidence: 99%
“…To decrease systemic and IA peak levels of corticosteroids, drug delivery systems for local application, in particular microspheres (MSs), are promising alternatives. These provide prolonged low‐level drug exposure with a lower risk of IA and systemic side effects (Janssen, Mihov, Welting, Thies, & Emans, ). The MSs are injected into the joint and, given their size, cannot leave this location.…”
Section: Introductionmentioning
confidence: 99%
“…Delivering drugs through oral administration to the targeted site takes long (1–5 h) and leads to the decrease of drug efficiency due to their gastrointestinal adsorption and systemic circulation. 59 , 60 Corticosteroid injection has a palliative (not curative) effect, is only used in severe acute pain, and generally for limited doses only. The effect of steroid on the disk is widely reported to irritate.…”
Section: Delivery Vehicles Of Therapeutic Moleculesmentioning
confidence: 99%