Drugs-in-cyclodextrins-in liposomes: a novel concept in drug delivery

McCormack, Brenda; Gregoriadis, Gregory

doi:10.1016/0378-5173(94)90361-1

Cited by 115 publications

(53 citation statements)

References 12 publications

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“…Therefore, the water-soluble bioactive agent-cyclodextrin complex is capable of being encapsulated within the aqueous compartments of the liposomes. An EE of 32.3 + 11.9% for dehydroepiandrosterone and 31.9 + 11.8% for hydroxypropyl-b-cyclodextrin was achieved by using this method [12,93].…”

Section: Lipophilic Bioactive Agentsmentioning

confidence: 99%

“…Therefore, the presence of Chol decreases the encapsulation of lipophilic bioactive agents [91,92]. A system has been proposed to enhance the EE of lipophilic bioactive agents [93]. This consists of combining liposomes and cyclodextrin-bioactive agent complexes by forming bioactive agent-in-cyclodextrins-in-liposomes [93].…”

Section: Lipophilic Bioactive Agentsmentioning

confidence: 99%

“…A system has been proposed to enhance the EE of lipophilic bioactive agents [93]. This consists of combining liposomes and cyclodextrin-bioactive agent complexes by forming bioactive agent-in-cyclodextrins-in-liposomes [93]. Cyclodextrins are hydrophobic inside and hydrophilic outside, cavity-forming, water-soluble oligosaccharides that can accommodate water-insoluble bioactive agents into their cavities, increasing their water solubility.…”

Section: Lipophilic Bioactive Agentsmentioning

confidence: 99%

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Liposomes in tissue engineering and regenerative medicine

Monteiro

Martins

Reis

et al. 2014

J. R. Soc. Interface.

329

217

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Liposomes are vesicular structures made of lipids that are formed in aqueous solutions. Structurally, they resemble the lipid membrane of living cells. Therefore, they have been widely investigated, since the 1960s, as models to study the cell membrane, and as carriers for protection and/or delivery of bioactive agents. They have been used in different areas of research including vaccines, imaging, applications in cosmetics and tissue engineering. Tissue engineering is defined as a strategy for promoting the regeneration of tissues for the human body. This strategy may involve the coordinated application of defined cell types with structured biomaterial scaffolds to produce living structures. To create a new tissue, based on this strategy, a controlled stimulation of cultured cells is needed, through a systematic combination of bioactive agents and mechanical signals. In this review, we highlight the potential role of liposomes as a platform for the sustained and local delivery of bioactive agents for tissue engineering and regenerative medicine approaches.

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Section: Lipophilic Bioactive Agentsmentioning

confidence: 99%

Section: Lipophilic Bioactive Agentsmentioning

confidence: 99%

Section: Lipophilic Bioactive Agentsmentioning

confidence: 99%

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Liposomes in tissue engineering and regenerative medicine

Monteiro

Martins

Reis

et al. 2014

J. R. Soc. Interface.

329

217

View full text Add to dashboard Cite

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“…Contrary to earlier reports, this may suggest that the non-uniformity of the W/O-droplets may influence the refractive index causing a potential overestimation of the initial average droplet size. Chen, Gao, Wang, & Liang, 2007;Maestrelli, Gonzalez-Rodriguez, Rabasco, & Mura, 2005;Mccormack & Gregoriadis, 1994;Piel, et al, 2006). As summarized in a recently published review article (J.…”

Section: Resultsmentioning

confidence: 99%

Ibuprofen-in-cyclodextrin-in-W/O/W emulsion – Improving the initial and long-term encapsulation efficiency of a model active ingredient

Hattrem

Kristiansen

Aachmann

et al. 2015

International Journal of Pharmaceutics

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A challenge with formulating water-in-oil-in-water (W/O/W) emulsions is the uncontrolled release of encapsulated compound prior to application. Pharmaceuticals and nutraceuticals usually have amphipathic nature, which may contribute to leakage of the active ingredient. In the present study, cyclodextrins (CyDs) were used to impart a change in the relative polarity and size of a model compound (ibuprofen) by the formation of inclusion complexes. Various inclusion complexes (2-hydroxypropyl (HP)-β-CyD-, α-CyD-and -CyD-ibuprofen) were prepared and presented within W/O/W emulsions and the initial and long-term encapsulation efficiency was investigated. HP-β-CyD-ibuprofen provided the highest retention of ibuprofen in comparison to a W/O/W emulsion with unassociated ibuprofen confined within the inner water phase, with a 4 fold increase in the encapsulation efficiency. An improved, although lower encapsulation efficiency was obtained for the inclusion complex -CyD-ibuprofen in comparison to HP-β-CyD-ibuprofen, while α-CyDibuprofen had similar encapsulation efficiency as unassociated ibuprofen. The lower encapsulation efficiency of ibuprofen in combination with α-CyD and γ-CyD was attributed to a lower association constant for the γ-CyD-ibuprofen inclusion complex and the ability of α-CyD to form inclusion complexes with fatty acids. For the W/O/W emulsion prepared with HP--CyD-ibuprofen, the highest retention of ibuprofen was obtained at hyper-and iso-osmotic conditions and by using an excess molar ratio of CyD in comparison to ibuprofen. In the last part of the study it was suggested that the chemical modification of the HP--CyD molecule did not influence the encapsulation of ibuprofen, as similar encapsulation efficiency was obtained for an inclusion complex prepared with mono-1-glucose--CyD.

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“…However, with a limited hydrophobic domain, the carriers can accommodate only a limited amount of hydrophobic drug and the drug/lipid ratio may be especially low for drugs that have a low affinity for the lipids (McCormack and Gregoriadis 1994a). Consequently, the administration of a large amount of carrier may be required to reach a therapeutic concentration (Perkins et al, 2000).…”

mentioning

confidence: 99%