Drugs in Pregnancy and Lactation – Medications Used in Swiss Obstetrics

Schenkel, Larissa; Simões‐Wüst, Ana Paula; Hösli, Irène; Mandach, Ursula von

doi:10.1055/s-0043-124975

Cited by 13 publications

(21 citation statements)

References 11 publications

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“…An assessment of the internal treatment recommendations in the main Swiss obstetrics centres showed that B. pinnatum preparations are being prescribed for the treatment of preterm contractions [21]. This is in line with a Swiss online survey which showed that in approximately ¾ of the cases B. pinnatum preparations are administered in combination with synthetic tocolytics [22].…”

Section: Introductionmentioning

confidence: 74%

Bryophyllum pinnatum enhances the inhibitory effect of atosiban and nifedipine on human myometrial contractility: an in vitro study

Santos

Haslinger

Mennet

et al. 2019

BMC Complement Altern Med

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BackgroundThe herbal medicine Bryophyllum pinnatum has been used as a tocolytic agent in anthroposophic medicine and, recently, in conventional settings alone or as an add-on medication with tocolytic agents such as atosiban or nifedipine. We wanted to compare the inhibitory effect of atosiban and nifedipine on human myometrial contractility in vitro in the absence and in the presence of B. pinnatum press juice (BPJ).MethodsMyometrium biopsies were collected during elective Caesarean sections. Myometrial strips were placed under tension into an organ bath and allowed to contract spontaneously. Test substances alone and at concentrations known to moderately affect contractility in this setup, or in combination, were added to the organ bath, and contractility was recorded throughout the experiments. Changes in the strength (measured as area under the curve (AUC) and amplitude) and frequency of contractions after the addition of all test substances were determined. Cell viability assays were performed with the human myometrium hTERT-C3 and PHM1–41 cell lines.ResultsBPJ (2.5 μg/mL), atosiban (0.27 μg/mL), and nifedipine (3 ng/mL), moderately reduced the strength of spontaneous myometrium contractions. When BPJ was added together with atosiban or nifedipine, inhibition of contraction strength was significantly higher than with the tocolytics alone (p = 0.03 and p < 0.001, respectively). In the case of AUC, BPJ plus atosiban promoted a decrease to 48.8 ± 6.3% of initial, whereas BPJ and atosiban alone lowered it to 70.9 ± 4.7% and to 80.9 ± 4.1% of initial, respectively. Also in the case of AUC, BPJ plus nifedipine promoted a decrease to 39.9 ± 4.6% of initial, at the same time that BPJ and nifedipine alone lowered it to 78.9 ± 3.8% and 71.0 ± 3.4% of initial. Amplitude data supported those AUC data. The inhibitory effects of BPJ plus atosiban and of BPJ plus nifedipine on contractions strength were concentration-dependent. None of the test substances, alone or in combination, decreased myometrial cell viability.ConclusionsBPJ enhances the inhibitory effect of atosiban and nifedipine on the strength of myometrial contractions, without affecting myometrium tissue or cell viability. The combination treatment of BPJ with atosiban or nifedipine has therapeutic potential.

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Section: Introductionmentioning

confidence: 74%

Bryophyllum pinnatum enhances the inhibitory effect of atosiban and nifedipine on human myometrial contractility: an in vitro study

Santos

Haslinger

Mennet

et al. 2019

BMC Complement Altern Med

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“…In the last decade, B. pinnatum began to be used at university institutions in Switzerland, where at present it constitutes an inherent part of the standard preterm contractions treatment (see [15]). The relatively low evidence level on which this use of B. pinnatum is based, together with the lack of fully efficacious and well-tolerated synthetic, tocolytic agents, makes the performance of randomised controlled trials urgent.…”

Section: Discussionmentioning

confidence: 99%

Two Randomised Clinical Trials on the Use of <b><i>Bryophyllum pinnatum</i></b> in Preterm Labour: Results after Early Discontinuation

et al. 2018

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“…In view of the present paucity of well‐tolerated and long‐term unproblematic treatments for RLS, our observations suggest that it might be worthwhile to treat RLS patients with (add‐on) BP preparations. These might be particularly indicated in the treatment of (frequent) RLS during pregnancy—especially if iron substitution is not needed or not enough—since the standard RLS medications are contra‐indicated in pregnancy and BP preparations are already recommended and in use for other indications . In a recent prospective observational study performed to assess BP prescriptions in the field of gynecology and obstetrics in Switzerland, one case showing a very good effect of BP medication on RLS during pregnancy was described .…”

Section: Discussionmentioning

confidence: 99%

Bryophyllum pinnatum in the treatment of restless legs syndrome: A case series documented with polysomnography

Manitius

Flügel

Steinlein

et al. 2019

Clinical Case Reports

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Key Clinical Message Restless legs syndrome may seriously affect patients' sleep and quality of life, but established pharmacological therapy can often have severe side effects. Therefore, new therapeutic approaches such as well‐tolerated preparations from the medicinal plant Bryophyllum pinnatum should be considered as alternatives. Their sedative and spasmolytic properties might contribute to improve patients' condition.

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Drugs in Pregnancy and Lactation – Medications Used in Swiss Obstetrics

Cited by 13 publications

References 11 publications

Bryophyllum pinnatum enhances the inhibitory effect of atosiban and nifedipine on human myometrial contractility: an in vitro study

Bryophyllum pinnatum enhances the inhibitory effect of atosiban and nifedipine on human myometrial contractility: an in vitro study

Two Randomised Clinical Trials on the Use of <b><i>Bryophyllum pinnatum</i></b> in Preterm Labour: Results after Early Discontinuation

Bryophyllum pinnatum in the treatment of restless legs syndrome: A case series documented with polysomnography

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