Dry-Coating of Powder Particles is Current Trend in Pharmaceutical Field

Abstract

Modification of surface attributes of particles, usually accomplished by coating, is desirous to enhance and maintain their usability. Coating is a multi-step process involves application of the coating material (CoM) onto the substrate, herein powder particles, where the process along with device/ equipment monitors surface attributes of the applied coating. Nowadays competitive market calls for cost cutting to survive product(s). Thus saving of energy and time, minimising number and quantity of additives, reducing and shortening process steps; consequently minimising the coating process cost are main goals while developing coating process for powder particle. Innovation of processes for dry-powder coating (DPC) along with their further development and refinement finds solution to said issues. Further, DPC process does not calls for liquid solvent or solution thus are viewed as cost-effective and environmentally safe, DPC process uses thermo-mechanical methods like mechanofusion, magnetic assisted impaction coating (MAIC), hybridization, rotating fluid-bed process, theta-composer, hot-melt coating (HMC), and many others. Besides these available are non-thermo-mechanical methods namely electrostatic coating; supercritical fluids (SCF) based methods like rapid expansion of supercritical fluid (RESF), gas anti-solvent (GAS), SCF anti-solvent, gas-saturated solution (GSS); vapour coating; and others. Basing on said thermo-mechanical and non-thermo-mechanical principle several DPC methods/ process had been reported in scientific literatures and patents. Said DPC method founds multidisciplinary applications like drug delivery and drug development. Diverse devices are there for the DPC process; their method of working, principle, limitations and benefits along with their applicability in pharmaceutical field are discussed and presented in this article.
 Keywords: Dry, particle, coating, pharmaceutical, process

Thermo-Mechanical Dry Coating as Dry Coating Process is for Pharmaceuticals

“…Amongst the diverse pharmaceutical products solid dosage forms are the most popular one 1,2 . In their manufacturing the most basic unit is FiUlFiPs whose handling is most inevitable 2,3 .…”

“…In their manufacturing the most basic unit is FiUlFiPs whose handling is most inevitable 2,3 . Further these possess extremely cohesive bulk flow and often tend to agglomerate [1][2][3] .…”

“…High surface area of FiUlFiPs is reasoning for receiving interest 1,2,4 . Researchers (scientists and engineers) in pharmaceutical sectors working extensively in finding applications and taking advantage of many worthy properties and new functionalities attributed to FiUlFiPs, as drug delivery system/carriers 1,2,5 .…”

“…High surface area of FiUlFiPs is reasoning for receiving interest 1,2,4 . Researchers (scientists and engineers) in pharmaceutical sectors working extensively in finding applications and taking advantage of many worthy properties and new functionalities attributed to FiUlFiPs, as drug delivery system/carriers 1,2,5 . They were exploiting numerous elegant strategies of particle engineering methods to modify density and/or shape of FiUlFiPs to resolve the problems caused by cohesion and find their worthy properties and new functionalities [1][2][3] .…”

“…Researchers (scientists and engineers) in pharmaceutical sectors working extensively in finding applications and taking advantage of many worthy properties and new functionalities attributed to FiUlFiPs, as drug delivery system/carriers 1,2,5 . They were exploiting numerous elegant strategies of particle engineering methods to modify density and/or shape of FiUlFiPs to resolve the problems caused by cohesion and find their worthy properties and new functionalities [1][2][3] . The surface modification strategy of FiUlFiPs is nowadays becoming vital in pharmaceutical sector for the active(s) that are difficult to formulate [1][2][3] .…”