Dry Eye Diagnosis

Khanal, Santosh; Tomlinson, Alan; McFadyen, Angus; Diaper, Charles; Ramaesh, K

doi:10.1167/iovs.07-0635

Cited by 141 publications

(107 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This TFSQ indicator has shown good performance to discriminate dry eye from normal tear film subjects and it performs similarly to other well established methods based on different principles, such as osmolarity 29 or tear turnover rate. 6 Also, our technique provides similar results to those reported by Mengher et al 8 who used a subjective assessment of the reflected Placido pattern to obtain tear film break-up time. The limited discrimination performance of any single method highlights the complexity of diagnosing dry eye syndrome.…”

Section: Summary and Discussionsupporting

confidence: 78%

“…After excluding the first second, in NBC only the first three seconds of interblink interval recording were considered while for the SBC, an 8 s recording was used. Receiver operating characteristics (ROC) curves, which determine the sensitivity and specificity of the measurement in diagnosing dry eye, 6 were calculated to show the capability of the two considered TFSQ indicators to discriminate dry eye from normal tear film subjects. To arrive at the best possible detection performance for the noninvasive test, a group of ROC curves were evaluated at different sampling intervals.…”

Section: Clinical Study 41 Protocolmentioning

confidence: 99%

“…3 Various noninvasive tear film assessment methods have been investigated, but with limited discrimination performance. [4][5][6][7][8][9] Therefore, it is of clinical importance to improve the techniques for the assessment of tear film and the diagnosis of dry eye.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Diagnosing dry eye with dynamic-area high-speed videokeratoscopy

Alonso‐Caneiro

Turuwhenua

Iskander³

et al. 2011

J. Biomed. Opt.

View full text Add to dashboard Cite

Abstract. Dry eye syndrome is one of the most commonly reported eye health conditions. Dynamic-area highspeed videokeratoscopy (DA-HSV) represents a promising alternative to the most invasive clinical methods for the assessment of the tear film surface quality (TFSQ), particularly as Placido-disk videokeratoscopy is both relatively inexpensive and widely used for corneal topography assessment. Hence, improving this technique to diagnose dry eye is of clinical significance and the aim of this work. First, a novel ray-tracing model is proposed that simulates the formation of a Placido image. This model shows the relationship between tear film topography changes and the obtained Placido image and serves as a benchmark for the assessment of indicators of the ring's regularity. Further, a novel block-feature TFSQ indicator is proposed for detecting dry eye from a series of DA-HSV measurements. The results of the new indicator evaluated on data from a retrospective clinical study, which contains 22 normal and 12 dry eyes, have shown a substantial improvement of the proposed technique to discriminate dry eye from normal tear film subjects. The best discrimination was obtained under suppressed blinking conditions. In conclusion, this work highlights the potential of the DA-HSV as a clinical tool to diagnose dry eye syndrome. C 2011 Society of Photo-Optical Instrumentation Engineers (SPIE).

show abstract

Section: Summary and Discussionsupporting

confidence: 78%

Section: Clinical Study 41 Protocolmentioning

confidence: 99%

See 1 more Smart Citation

Diagnosing dry eye with dynamic-area high-speed videokeratoscopy

Alonso‐Caneiro

Turuwhenua

Iskander³

et al. 2011

J. Biomed. Opt.

View full text Add to dashboard Cite

show abstract

“…Regardless of the initial stimulus, there is an inflammatory vicious circle on the ocular surface, leading to gradual dysfunction of secretion or tear retention. What is not clear is whether, with so many different mechanisms and even without inflammation in the initial stages, there would be a common diagnostic examination with a similar cutoff value in different disease groups, and what would be the correlation of this parameter with others used in clinical practice and its limitations (26) .Furthermore, we do not today have curing measures to reverse dry eye, only chronic and palliative treatments (27) .Faced by these doubts, it becomes necessary to improve animal models for the study of the disease and to improve knowledge of the disease mechanisms and definitive therapeutic strategies.…”

Section: Introductionmentioning

confidence: 99%

Lacrimal osmolaritu and ocular surface in experimental model of dry eye caused by toxicity

Marques¹,

Alves²,

Módulo³

et al. 2015

Revista Brasileira De Oftalmologia

View full text Add to dashboard Cite

The authors declare no conflict of interest. Objetivo: Descrever um modelo animal de olho seco induzido pela aplicação tópica de cloreto de benzalcônio (BAC) e avaliar marcadores de ABSTRACT RESUMOPurpose: Describe an animal model of dry induced by topical instillation of BAK and evaluate ocular surface biomarkers and histological findings. Methods: Male Wistar rats were used. Topical instillation of 0.2% BAK eyedrops twice a day during 7 days, in the right eye of each animal, while the other eye was taken as control. After 7 days treatment, we performed evaluation of tear film osmolarity, the red phenol thread and ocular surface staining with fluorescein and lissamine green. Afterwards, the animals were sacrificed for tissue extraction and histological evaluation under optical microscopy and H&E staining. Results: Compared with untreated controls, the BAK-group presented tear secretion significantly decreased, increased ocular surface staining by fluorescein and lissamine green and tear film hyperosmolarity (p <0,05). Histological evaluation revealed epithelial thinning and estromal oedema. Conclusion: A toxicity animal model of dry eye induced by topical instillation of benzalkonium chloride, which presents corneal and ocular surface alterations, decreased tear film volume and tear hyperosmolarity as seen in dry eye condition.

show abstract

“…Based on OSDI score, the ocular surface is defined as normal (0-12), mild (13)(14)(15)(16)(17)(18)(19)(20)(21)(22), moderate (23)(24)(25)(26)(27)(28)(29)(30)(31)(32), or severe (33-100) [44]. It is noteworthy that although the OSDI is not routinely used in clinical practice, it has been shown to be valid and reliable to quantify the impact of dry eye on the quality of life [44].…”

Section: Discussionmentioning

confidence: 99%