Dry powder inhaler aerosol deposition in a model of tracheobronchial airways: Validating CFD predictions with in vitro data

Ahookhosh, Kaveh; Saidi, Maysam; Aminfar, Habib; Mohammadpourfard, Mousa; Hamishehkar, Hamed; Yaqoubi, Shadi

doi:10.1016/j.ijpharm.2020.119599

Cited by 36 publications

(17 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, namely, a 3D numerical model was established from the acquired CT image data of the upper airway of healthy subjects, and CFD methods were applied to conduct relevant experiments to simulate the real human upper airway environment. During the study, the deposition e ciency [21][22][23] was compared with the inertial parameter, i.e. da2×Q(µm2cm3/s) [16,21,22] , where Q and da represent inhalation ow and particle diameter, respectively (Fig.…”

Section: Discussionmentioning

confidence: 99%

Biomechanical study of particle deposition in the nasal and nasopharyngeal cavities of healthy subjects

Yang

Sun

Tang

et al. 2022

Preprint

View full text Add to dashboard Cite

To build a finite element numerical model of the nasal and nasopharyngeal cavities in healthy subjects and analyze the particle deposition characteristics of the nasal and nasopharyngeal cavities under different conditions, in order to investigate the influencing factors of particle deposition in the nasal and nasopharyngeal cavities of healthy subjects from the perspective of biomechanics, and to provide reference for the potential predisposing factors of clinical nasal and nasopharyngeal diseases and transnasal drug delivery methods. The nasal multi-layer spiral CT data of a healthy adult male volunteer was collected, and a three-dimensional numerical model was reconstructed based on the obtained image data (the model included nasal cavity, nasopharyngeal cavity, and pharyngeal cavity), and then numerical simulations were performed for particle deposition under different airflow rate, particle size and particle density conditions. In the reconstructed model, the nasal threshold, the nasal vestibule, the anterior part of the inferior and middle turbinates, and the posterior wall of the nasopharyngeal apex are the most likely areas for particle settling. When the airflow rate was 30L/min and 60L/min, the deposition efficiency(DE) of the reconstructed model was more than 80% with different particle diameters and particle densities. When the particle diameter is 10um and 15um, the deposition efficiency of the reconstructed model can reach more than 90% under different airflow rate and particle density. When the particle density and airflow rate were constant, the deposition efficiency of particles in the posterior wall of the nasopharynx decreased as the particle diameter became larger. A numerical model of nasal and nasopharyngeal cavity biomechanics can be established to explore the important influencing factors of particle deposition in the nasal and nasopharyngeal cavities from a biomechanical perspective. It was found that: 1. particle deposition mainly at the nasal threshold and nasal vestibule in the nasal cavity, and mainly at the posterior wall of the nasopharyngeal apex in the nasopharyngeal cavity; 2. airflow velocity, particle size and density all had effects on particle deposition rate, among which particle size had the greatest effect on particle deposition, followed by airflow rate, and the effect of particle density changes on particle deposition was not significant; 3. when particle density and airflow rate were constant, the smaller the particle diameter, the the more particle deposition in the nasopharyngeal cavity, the larger the particle diameter, the more particle deposition increases in the anterior part of the nasal cavity, and the less particle deposition in the nasopharyngeal cavity; 4. As the particle diameter increases, the particle deposition in this reconstructed model increases.

show abstract

Section: Discussionmentioning

confidence: 99%

Biomechanical study of particle deposition in the nasal and nasopharyngeal cavities of healthy subjects

Yang

Sun

Tang

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…They found that MDI delivered more drugs than DPI. They also carried out a CFD study to address the limitations of their previous study (Ahookhosh et al, 2020). As presented in a recent publication, Ahookhosh et al (Ahookhosh et al, 2021) examined the optimization of a Pressurized Metered Dose Inhaler (pMDI) in a human airway model.…”

Section: Longest Et Al (W Longest Et Al 2019mentioning

confidence: 99%

Swirling Flow and Capillary Diameter Effect on the Performance of an Active Dry Powder Inhalers (DPI)

Taheri

Askari

Feng

et al. 2022

Preprint

View full text Add to dashboard Cite

For patients with lung disease, dry powder inhalers (DPI) are profoundly beneficial. The current study introduces and develops a series of dry powder inhalers (DPIs). A capsule-based (size 0) active DPI was considered. The study aims to investigate whether swirling flow and outlet capillary diameter (dc_out) affect the percentage of emitted doses (ED) released from the capsule. Spiral vanes were added to the capillary inlet to produce a swirling flow. Computational fluid dynamics (CFD) was applied to simulate the problem. The results were compared with previous in vitro and numerical studies to validate the results. Based on the derived results, the small swirl parameter (SP) enhances the secondary flow and recirculation zone. It increases the central jet flow, which increases the ED value by about 5-20% compared to no-swirl flow. However, as the airflow rate increases, the recirculation zone enlarges, vorticities become dominant, and asymmetrical flow patterns emerge. Consequently, ED % drops significantly (more than 50%). As dc_out decreases, the vorticities around the outlet capillary become more potent, which is undesirable. Indeed, the emptying of the capsule does not happen ideally. The research provides a perspective on the device's design and DPI performance.

show abstract

“…Moreover, it was time and labor consuming to conduct NGI tests since the complicated operation and followed up quantification required an entire day for only one measurement, and thus severely hampered the efficiency of the industrialization processes. CFD-DEM model was a powerful tool to simulate the behavior of fluid–particle interactions 10 , and was successfully employed in DPIs to aid the analyzing particle motion in the inhaler devices 11 , throat 12 and bronchi 3D models 13 , 14 . However, the crucial physical properties, such as the particle shape, surface roughness and particle size distribution, were often over simplified in CFD-DEM model.…”

Section: Introductionmentioning

confidence: 99%

A real-time and modular approach for quick detection and mechanism exploration of DPIs with different carrier particle sizes

Cui

Huang

Zhang

et al. 2022

Acta Pharmaceutica Sinica B

View full text Add to dashboard Cite

Dry powder inhalers (DPIs) had been widely used in lung diseases on account of direct pulmonary delivery, good drug stability and satisfactory patient compliance. However, an indistinct understanding of pulmonary delivery processes (PDPs) hindered the development of DPIs. Most current evaluation methods explored the PDPs with over-simplified models, leading to uncompleted investigations of the whole or partial PDPs. In the present research, an innovative modular process analysis platform (MPAP) was applied to investigate the detailed mechanisms of each PDP of DPIs with different carrier particle sizes (CPS). The MPAP was composed of a laser particle size analyzer, an inhaler device, an artificial throat and a pre-separator, to investigate the fluidization and dispersion, transportation, detachment and deposition process of DPIs. The release profiles of drug, drug aggregation and carrier were monitored in real-time. The influence of CPS on PDPs and corresponding mechanisms were explored. The powder properties of the carriers were investigated by the optical profiler and Freeman Technology four powder rheometer. The next generation impactor was employed to explore the aerosolization performance of DPIs. The novel MPAP was successfully applied in exploring the comprehensive mechanism of PDPs, which had enormous potential to be used to investigate and develop DPIs.

show abstract

Dry powder inhaler aerosol deposition in a model of tracheobronchial airways: Validating CFD predictions with in vitro data

Cited by 36 publications

References 46 publications

Biomechanical study of particle deposition in the nasal and nasopharyngeal cavities of healthy subjects

Biomechanical study of particle deposition in the nasal and nasopharyngeal cavities of healthy subjects

Swirling Flow and Capillary Diameter Effect on the Performance of an Active Dry Powder Inhalers (DPI)

A real-time and modular approach for quick detection and mechanism exploration of DPIs with different carrier particle sizes

Contact Info

Product

Resources

About