Drying at high temperature for a short time maximizes the recovery of olive leaf biophenols

Kamran, Muhammad; Hamlin, Adam; Scott, Christopher J.; Obied, Hassan K.

doi:10.1016/j.indcrop.2015.10.031

Cited by 33 publications

(34 citation statements)

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“…Despite its limitations and lack of selectivity, Folin-Ciocalteu's reagent is still the best technique for gross estimation of total phenol content (Kamran, Hamlin, Scott, & Obied, 2015).…”

Section: Total Phenolic Content (Tpc)mentioning

confidence: 99%

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Biophenols of mints: Antioxidant, acetylcholinesterase, butyrylcholinesterase and histone deacetylase inhibition activities targeting Alzheimer’s disease treatment

Hanafy

Prenzler

Burrows

et al. 2017

Journal of Functional Foods

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“…Despite its limitations and lack of selectivity, Folin-Ciocalteu's reagent is still the best technique for gross estimation of total phenol content (Kamran, Hamlin, Scott, & Obied, 2015).…”

Section: Total Phenolic Content (Tpc)mentioning

confidence: 99%

“…No one method is completely satisfactory for the accurate determination of the total phenol content in plants, therefore, chromatographic analysis together with determination of antioxidant activity is becoming essential for accurate estimation of phenolic composition (Kamran et al, 2015).…”

Section: Phenolic Composition Of Mintsmentioning

confidence: 99%

Biophenols of mints: Antioxidant, acetylcholinesterase, butyrylcholinesterase and histone deacetylase inhibition activities targeting Alzheimer’s disease treatment

Hanafy

Prenzler

Burrows

et al. 2017

Journal of Functional Foods

Self Cite

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“…Leaves were removed by filtration, followed by water evaporation under reduced pressure. [13] 1 HNMR (300 MHz, CD 3 Z181099-1EA Aldrich) and under argon atmosphere, was added 1 (20 mg, 0.04 mmol) dissolved in dry MeOH (2 mL), followed by addition of the acid promoter (2 mmol, 1 m). The insoluble material was filtered out and the solvent removed under reduced pressure to give a brown oil [14b] containing 1,w hich was purified by flash chromatography silica column using dichloromethane/methanol (DCM/MeOH, 1:0t o8 :2) to yield 1 [3 g, 1.5 %( w/w dried olive leaves)] as a yellow amorphous solid.…”

Section: Isolation Of 1f Rom Olive Leavesmentioning

confidence: 99%

Valorization of Oleuropein via Tunable Acid‐Promoted Methanolysis

et al. 2018

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The acid-promoted methanolysis of oleuropein was studied using a variety of homogeneous and heterogeneous acid catalysts. Exclusive cleavage of the acetal bond between the glucoside and the monoterpene subunits or further hydrolysis of the hydroxytyrosol ester and subsequent intramolecular rearrangement were observed upon identification of the most efficient catalyst and experimental conditions. Furthermore, selected conditions were tested using oleuropein under continuous flow and using a crude mixture extracted from olive leaves under batch. Formation of (-)-methyl elenolate was also observed in this study, which is a reported precursor for the synthesis of the antihypertensive drug (-)-ajmalicine.

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“…[4,5] In the current research, pre-treatment, i.e., hot blanching assisted microwave extraction technique using glycerol as biosolvent was chosen for extraction process to reduce matrix effects and enhance leaching of oleuropein. [6][7][8][9] Meningitis, a chronic disease characterized by inflammation in meninges of brain. At present, the second-generation cephalosporins are preferred choice to alleviate the disease which offers a serious disadvantage like multidrug resistance (MDR).…”

Section: Introductionmentioning

confidence: 99%

Untitled

Reddy¹

2019

AJP

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Background: Olive leaf, a versatile plant obtained from Olea europaea which was enriched with various secondary metabolites likes polyphenols, secoirodiods eg. Oleuropein, Hydroxytyrosol etc. Current treatment modalities for meningitis were ended up with MDR. Hence, a new strategy is mandate to alleviate bacterial meningitis. Objective: Current research structured to identify the potential of Oleuropein loaded NLC in the inhibition of Bacterial Meningitis. Glycerol is used as bio-solvent in hot blanching assisted microwave extraction & extracts were analyzed by using UV, FTIR, HPTLC and HPLC to quantify the Oleuropein. Methodology: NLC was formulated by melt dispersion ultrasonication method using Box-behnken design. Formulated NLC was analyzed for particle size, zeta potential and in-vitro drug release studies. Toxicity and Histo-pathological examination was done in albino Wistar rats using cerebellar cistern puncture method to estimate In-vivo potential of Oleuropein in bacterial meningitis. Results and Discussion: From the data, it was observed that hot blanching process potentiates the extraction and the data depicts that aqueous glycerol extract contain huge amount of Oleuropein. Optimized NLC resides with 165nm of size, ZP of -40mv and PDI of 0.3 with a sustainable release of drug for 12hrs. By Histo-pathological examination, regeneration of brain tissue was initiated in the hippocampus region in treated group as compared to control group. Conclusion: Combination of hot blanching with microwave extraction for Oleuropein and subsequent loading of drug into NLC shown significant positive effect on treatment of Streptococcal meningitis.

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Drying at high temperature for a short time maximizes the recovery of olive leaf biophenols

Cited by 33 publications

References 38 publications

Biophenols of mints: Antioxidant, acetylcholinesterase, butyrylcholinesterase and histone deacetylase inhibition activities targeting Alzheimer’s disease treatment

Biophenols of mints: Antioxidant, acetylcholinesterase, butyrylcholinesterase and histone deacetylase inhibition activities targeting Alzheimer’s disease treatment

Valorization of Oleuropein via Tunable Acid‐Promoted Methanolysis

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