Drying of bio-colloidal sessile droplets: Advances, applications, and perspectives

Pal, Anusuya; Gope, Amalesh; Sengupta, Anupam

doi:10.1016/j.cis.2023.102870

Cited by 22 publications

(12 citation statements)

References 236 publications

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“…As explained before in previous sections, surface wettability can determine the internal flow, mixing, and reaction kinetics of samples within microfluidic systems using droplet architecture, affecting the performance of diagnostic tests. For instance, the capillary flow present in droplets evaporating on hydrophilic substrates and transporting particles present in the droplet to the contact line is leveraged in many biological and biomedical applications. − Furthermore, when particles move toward the contact line, the curvature of the liquid gas interface dictates that smaller particles can move further toward the contact line than larger particles, enabling separation of particles based on size (Figure a). Utilizing this phenomenon, Wong et al sorted bacteria, cells, and antibodies in an evaporating drop.…”

Section: Applicationsmentioning

confidence: 99%

Fundamentals and Applications of Surface Wetting

Josyula,

Kumar Malla,

Thomas

et al. 2024

Langmuir

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In an era defined by an insatiable thirst for sustainable energy solutions, responsible water management, and cutting-edge lab-on-a-chip diagnostics, surface wettability plays a pivotal role in these fields. The seamless integration of fundamental research and the following demonstration of applications on these groundbreaking technologies hinges on manipulating fluid through surface wettability, significantly optimizing performance, enhancing efficiency, and advancing overall sustainability. This Review explores the behavior of liquids when they engage with engineered surfaces, delving into the farreaching implications of these interactions in various applications. Specifically, we explore surface wetting, dissecting it into three distinctive facets. First, we delve into the fundamental principles that underpin surface wetting. Next, we navigate the intricate liquid−surface interactions, unraveling the complex interplay of various fluid dynamics, as well as heat-and mass-transport mechanisms. Finally, we report on the practical realm, where we scrutinize the myriad applications of these principles in everyday processes and real-world scenarios.

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Section: Applicationsmentioning

confidence: 99%

Fundamentals and Applications of Surface Wetting

Josyula,

Kumar Malla,

Thomas

et al. 2024

Langmuir

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“…It carries significant physiological information. − It is an ultradilute yet nutrient-rich fluid consisting of 98% water and 2% solutes that include various amino acids, metabolites, and inorganic components such as salts . The evaporation and deposition dynamics of biofluid droplets exhibit a high level of complexity. − The complexity inherent in biofluid droplets alters their evaporation dynamics by manipulating their hydrodynamic and thermodynamic properties. Research on simpler systems, such as salt or salt–protein droplets, has indicated that varying the salt ratio or protein percentage results in diverse crystalline morphologies, which can indicate different evaporation dynamics. − The presence of salts and certain biocomponents can affect a droplet’s ability to evaporate entirely, implying that these solutes may possess hygroscopic properties that result in the sorption of water vapor from the surrounding environment when the air is unsaturated .…”

Section: Introductionmentioning

confidence: 99%

Heat Transfer by Sweat Droplet Evaporation

Beigtan,

Gonçalves,

Weon

2024

Environ. Sci. Technol.

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Sweating regulates the body temperature in extreme environments or during exercise. Here, we investigate the evaporative heat transfer of a sweat droplet at the microscale to unveil how the evaporation complexity of a sweat droplet would affect the body's ability to cool under specific environmental conditions. Our findings reveal that, depending on the relative humidity and temperature levels, sweat droplets experience imperfect evaporation dynamics, whereas water droplets evaporate perfectly at equivalent ambient conditions. At low humidity, the sweat droplet fully evaporates and leaves a solid deposit, while at high humidity, the droplet never reaches a solid deposit and maintains a liquid phase residue for both low and high temperatures. This unprecedented evaporation mechanism of a sweat droplet is attributed to the intricate physicochemical properties of sweat as a biofluid. We suppose that the sweat residue deposited on the surface by evaporation is continuously absorbing the surrounding moisture. This route leads to reduced evaporative heat transfer, increased heat index, and potential impairment of the body's thermoregulation capacity. The insights into the evaporative heat transfer dynamics at the microscale would help us to improve the knowledge of the body's natural cooling mechanism with practical applications in healthcare, materials science, and sports science.

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“…In contrast, patterns that emerge from drying sessile droplets, often found to have the “coffee ring effect” [ 8 ], have also been investigated in soft matter. When a liquid droplet containing solutes evaporates, it can leave behind distinctive patterns [ 9 ]. Understanding the dynamics of a drying droplet and the resultant pattern formation is not only interesting from a fundamental physics perspective but also has practical applications in various fields, including inkjet printing [ 10 ], coating technologies [ 11 ], and bio-medical diagnostics [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…When a liquid droplet containing solutes evaporates, it can leave behind distinctive patterns [ 9 ]. Understanding the dynamics of a drying droplet and the resultant pattern formation is not only interesting from a fundamental physics perspective but also has practical applications in various fields, including inkjet printing [ 10 ], coating technologies [ 11 ], and bio-medical diagnostics [ 9 ]. Recently, it has been investigated how the morphological patterns emerge when the optically active particles (5CB) are used as a probe in the different protein drying droplets [ 2 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Texture identification in liquid crystal-protein droplets using evaporative drying, generalized additive modeling, and K-means Clustering

Pal,

Gope

2024

Eur. Phys. J. E

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Sessile drying droplets manifest distinct morphological patterns, encompassing diverse systems, viz., DNA, proteins, blood, and protein-liquid crystal (LC) complexes. This study employs an integrated methodology that combines drying droplet, image texture analysis (features from First Order Statistics, Gray Level Co-occurrence Matrix, Gray Level Run Length Matrix, Gray Level Size Zone Matrix, and Gray Level Dependence Matrix), and statistical data analysis (Generalized Additive Modeling and K-means clustering). It provides a comprehensive qualitative and quantitative exploration by examining LC-protein droplets at varying initial phosphate buffered concentrations (0x, 0.25x, 0.5x, 0.75x, and 1x) during the drying process under optical microscopy with crossed polarizing configuration. Notably, it unveils distinct LC-protein textures across three drying stages: initial, middle, and final. The Generalized Additive Modeling (GAM) reveals that all the features significantly contribute to differentiating LC-protein droplets. Integrating the K-means clustering method with GAM analysis elucidates how textures evolve through the three drying stages compared to the entire drying process. Notably, the final drying stage stands out with well-defined, non-overlapping clusters, supporting the visual observations of unique LC textures. Furthermore, this paper contributes valuable insights, showcasing the efficacy of drying droplets as a rapid and straightforward tool for characterizing and classifying dynamic LC textures. Graphical Abstract

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Drying of bio-colloidal sessile droplets: Advances, applications, and perspectives

Cited by 22 publications

References 236 publications

Fundamentals and Applications of Surface Wetting

Fundamentals and Applications of Surface Wetting

Heat Transfer by Sweat Droplet Evaporation

Texture identification in liquid crystal-protein droplets using evaporative drying, generalized additive modeling, and K-means Clustering

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