DSC Examination of the oesophagus after two different self-expandable stents implantation

Benkő, László; Danis, J; Czompo, M.; Hubmann, Rainer; Ferencz, A.; Jancsó, Gábor; Szántó, Zalán; Zólyomi, Annamária; Könczöl, Franciska; Bellyei, A; Röth, Erzsébet; Lőrinczy, D.

doi:10.1007/s10973-005-7434-9

Cited by 15 publications

(4 citation statements)

References 11 publications

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“…Benkő et al [13] published the original animal data on the use of SEMSs in variceal bleeding. SEMSs were inserted into dogs with variceal bleeding, and esophageal histology, tissue oxygen saturation, and thermal denaturation requirements were analyzed following stent placement.…”

Section: Preclinical and Early Experience With The Use Of Semss For Vmentioning

confidence: 99%

Endoprosthetics for bleeding esophageal varices

Dannhorn

O’Beirne

2014

Techniques in Gastrointestinal Endoscopy

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Section: Preclinical and Early Experience With The Use Of Semss For Vmentioning

confidence: 99%

Endoprosthetics for bleeding esophageal varices

Dannhorn

O’Beirne

2014

Techniques in Gastrointestinal Endoscopy

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“…Implants have been used in the treatment of conditions of the esophagus, the heart, and in orthopedics. Benko et al [21] investigated two different metal stents, 1 and 2, implanted into the esophagus. DSC curves for stent 1 showed higher melting points, compared to the control and stent 2.…”

Section: Implantsmentioning

confidence: 99%

Thermoanalytical methods applied to medicine

Glass

Brown

2009

Pure and Applied Chemistry

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Thermoanalytical methods have found increasing application in medicine due to the improved sensitivity and usability of the available instrumentation. Studies have identified important findings applied to medicine, including information on the thermal properties of the skin and the effect of insertion into body cavities of implants and prosthetics. These studies have explored the thermal stability of various materials to provide insight into drug penetration in order to design drug delivery systems, which are not only safe but capable of delivering improved and predictable therapeutic outcomes for patients. Differential scanning calorimetry (DSC) has also been applied to the study of disease states such as diabetes, where changes in the collagen structure of the skin, which may lead to long-term complications in these patients, can be detected. Although these results may at this stage not have significant clinical implications, they do provide medical researchers with a starting point for future investigations. The application of these techniques has been further extended to examinations of body systems and other disease states. The key for the future will be the ability of these techniques not only to provide information on alterations in these biological systems, but also to determine whether these alterations are clinically relevant.

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“…Although use of the device has been limited in real clinical practice within the USA, SEMS placement has shown promising results to date . Current standard luminal stents are not amenable to achieving hemostasis in acute variceal hemorrhage; however, a specialized SEMS has been developed for this select patient population . This dedicated SEMS device is a removable, covered stent deployed endoscopically with the use of a guidewire.…”

Section: Introductionmentioning

confidence: 99%

“…8 Current standard luminal stents are not amenable to achieving hemostasis in acute variceal hemorrhage; however, a specialized SEMS has been developed for this select patient population. 20,21 This dedicated SEMS device is a removable, covered stent deployed endoscopically with the use of a guidewire. Early technical and clinical success shown in previous studies merits further consideration and advancement into mainstream clinical practice.…”

Section: Introductionmentioning

confidence: 99%

Self‐expanding metal stents for acute refractory esophageal variceal bleeding: A systematic review and meta‐analysis

McCarty

Njei

2016

Digestive Endoscopy

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Objectives Esophageal variceal bleeding is a severe complication of portal hypertension with significant morbidity and mortality. A substantial portion of cirrhotics fail to respond to conventional medical therapy and band ligation, necessitating alternative treatments including SEMS placement for acute refractory esophageal variceal bleeding. To perform a systematic review and structured meta-analysis of all eligible studies to evaluate the technically feasibility, safety, clinical efficacy, and survival advantage of SEMS for the treatment of acute esophageal variceal bleeding. Methods Searches of PubMed, EMBASE, Web of Science, and the Cochrane Library databases were performed through December 2015. Individual study proportions were transformed into a quantity using the Freeman – Tukey variant of the arcsine square root transformed proportion. Combined weighted proportions, and meta-regression were then determined. Results The search yielded 12 studies involving n=155 patients, included in our meta-analysis. The pooled clinical success rate in achieving hemostasis within 24 hours was 96% (95% CI, 0.90–1.00). Technical success for SEMS deployment endoscopically was achieved in 97% of patients (95% CI, 0.91–1.00). Total adverse events (including rebleeding after 48 hours, ulceration, and stent migration) were shown in 36% of patients after SEMS placement (95% CI, 0.23–0.50). The pooled 30 day and 60 day survival rate was 68% (95% CI, 0.56–0.80) and 64% (95% CI, 0.48–0.78), respectively. Conclusion This study demonstrated that esophageal SEMS placement is a technically feasible modality and highly efficacious in achieving hemostasis in acute esophageal variceal hemorrhage.

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DSC Examination of the oesophagus after two different self-expandable stents implantation

Cited by 15 publications

References 11 publications

Endoprosthetics for bleeding esophageal varices

Endoprosthetics for bleeding esophageal varices

Thermoanalytical methods applied to medicine

Self‐expanding metal stents for acute refractory esophageal variceal bleeding: A systematic review and meta‐analysis

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