DTI Study of Cerebral Normal-Appearing White Matter in Hereditary Neuropathy With Liability to Pressure Palsies (HNPP)

Abstract

The majority of previous studies on hereditary neuropathy with liability to pressure palsies (HNPP) were focused on peripheral nerves, whereas cerebral alterations in HNPP have been less attended to. In this work, Diffusion tensor imaging (DTI) was used to detect the changes in WM, especially in the normal-appearing white matter (NAWM) in HNPP patients for its sensitivity in probing the microstructure of WM, the sensitive metric was searched for probing cerebral alterations and the regional distribution of cerebral abnormalities was identified. Twelve HNPP patients and 12 age- and gender-matched healthy controls underwent the conventional MRI, DTI scan, and electrophysiological examination. The conventional MRI images were first analyzed to identify abnormal intense regions and the NAWM regions. NAWM refers to the white matter regions that do not include the lesions on conventional MRI. The apparent diffusion coefficient and fractional anisotropy (FA) values of the NAWM were then measured and compared between patient and control groups. The sensitivity and specificity of 3 methods and the cerebral regional distribution of MR signal abnormalities were further analyzed. Hyperintense foci were observed on T2 weighted image and fluid attenuated inversion recovery images in 6 patients. Compared to the controls, FA values of the patients were significantly lower in bilateral frontal, orbitofrontal, and temporal NAWMs; whereas the electrophysiological examination results of patients and controls exhibited no statistically significant difference. The sensitivity of FA value was higher than that of electrophysiological examination and conventional MRI. The majority of abnormal signals on conventional MRI images and abnormal FA values were located in the frontal and temporal lobes. The results of our study show cerebral WM changes in HNPP patients. FA value in DTI has been shown to be sensitive to the cerebral microstructural changes in HNPP. The frontal lobe is the predilection site that is most involved in HNPP.

Schizophrenia and Hereditary Polyneuropathy: PMP22 Deletion as a Common Pathophysiological Link?

“…Recent studies suggested the important involvement of the CNS in most patients with PMP22 deletion (18, 19). This is supported by prolonged latencies of visual evoked potentials, neurochemical alterations with decreased N -acetylaspartate (NAA) and creatine (Cre) concentrations, white matter (WM) volume reduction detected by cMRI, cognitive impairment (in 70% of patients), and fractional anisotropy alteration in several WM regions (e.g., in the columns of the fornix) (18–20). A large family study described CNS involvement and WM lesions predominantly in the subcortical frontal WM (21).…”

Central Nervous System Correlates of “Objective” Neuropathy in Alcohol Use Disorder

“…With respect to frontal regions, hereditary neuropathy has been associated with white matter disturbances in frontal regions (Wang et al, 2015); both chemotherapy-induced (Boland et al, 2014, Nudelman et al, 2016) and diabetic (Li et al, 2018, Manor et al, 2012) neuropathies show altered frontal activity. Furthermore, frontoparietal regions are relevant to encoding vibrotactile stimuli (Woolgar and Zopf, 2017) (see also, Godde et al, 2010, Wu et al, 2018, Fassihi et al, 2017, Ku et al, 2007, Soros et al., 2007).…”

Afferent Visual Pathway Affection in Patients with PMP22 Deletion-Related Hereditary Neuropathy with Liability to Pressure Palsies

“…This is supported by a recent report about fractional anisotropy abnormalities in central nervous system white matter detected with diffusion tensor imaging in HNPP patients. [ 41 ] Alternatively, the detected MRS alterations might reflect functional changes resulting from altered nerve conduction in HNPP patients rather than structural changes.…”