DTX3L/ARTD9 contributes to inflammation of fibroblast-like synoviocytes by increasing STAT1 translocation

Hong, Ruilong; Wang, Yuwu; Dong, Hong-Hua; Geng, Rui

doi:10.1016/j.tice.2020.101339

Cited by 2 publications

(2 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For instance, during viral infection, the PARP9/DTX3L complex targets histone H2BJ by interacting with signal transducer and activator of transcription 1 (STAT1) ( Zhang et al, 2015 ). Meanwhile, in rheumatoid arthritis, DTX3L induces fibroblast-like synoviocytes (FLS) to produce inflammatory cytokines via the STAT1 signal transduction pathway ( Hong et al, 2020 ). A low level of RNA N 6 -methyladenosine methyltransferase methyltransferase-like 3 (METTL3) has been reported in tissues of cerebral arteriovenous malformations.…”

Section: Functions and Associated Molecular Mechanisms Of The Dtx Familymentioning

confidence: 99%

Functions and Molecular Mechanisms of Deltex Family Ubiquitin E3 Ligases in Development and Disease

Wang

Sun

et al. 2021

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Ubiquitination is a posttranslational modification of proteins that significantly affects protein stability and function. The specificity of substrate recognition is determined by ubiquitin E3 ligase during ubiquitination. Human Deltex (DTX) protein family, which functions as ubiquitin E3 ligases, comprises five members, namely, DTX1, DTX2, DTX3, DTX3L, and DTX4. The characteristics and functional diversity of the DTX family proteins have attracted significant attention over the last decade. DTX proteins have several physiological and pathological roles and are closely associated with cell signal transduction, growth, differentiation, and apoptosis, as well as the occurrence and development of various tumors. Although they have been extensively studied in various species, data on structural features, biological functions, and potential mechanisms of action of the DTX family proteins remain limited. In this review, recent research progress on each member of the DTX family is summarized, providing insights into future research directions and potential strategies in disease diagnosis and therapy.

show abstract

Section: Functions and Associated Molecular Mechanisms Of The Dtx Familymentioning

confidence: 99%

Functions and Molecular Mechanisms of Deltex Family Ubiquitin E3 Ligases in Development and Disease

Wang

Sun

et al. 2021

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

show abstract

“…The DTX3L gene, also known as BBAP (B-lymphoma and BAL-associated protein), plays regulatory functions on DNA damage signaling, tumor cell growth, and IFN signaling and antiviral response [ 53 – 55 ]. Interestingly, Hong et al [ 56 ] reported that inhibiting the DTX3L gene restrained the cell invasion and secretion of inflammatory factors, suggesting its potential as a therapeutic target for rheumatoid arthritis, a complex autoimmune disease characterized by chronic synovitis of the joints in humans. The PARP9 and PARP14 genes, located within the ROH island on chromosome 6 (121,883,426:122,139,161 bp), belong to the PARP superfamily that regulate diverse biological processes such as DNA damage repair, cellular stress response, and antiviral innate immunity [ 57 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of consensus homozygous regions and their associations with growth and feed efficiency traits in American mink

Davoudi,

Do,

Rathgeber

et al. 2024

BMC Genom Data

View full text Add to dashboard Cite

The recent chromosome-based genome assembly and the newly developed 70K single nucleotide polymorphism (SNP) array for American mink (Neogale vison) facilitate the identification of genetic variants underlying complex traits in this species. The objective of this study was to evaluate the association between consensus runs of homozygosity (ROH) with growth and feed efficiency traits in American mink. A subsample of two mink populations (n = 2,986) were genotyped using the Affymetrix Mink 70K SNP array. The identified ROH segments were included simultaneously, concatenated into consensus regions, and the ROH-based association studies were carried out with linear mixed models considering a genomic relationship matrix for 11 growth and feed efficiency traits implemented in ASReml-R version 4. In total, 298,313 ROH were identified across all individuals, with an average length and coverage of 4.16 Mb and 414.8 Mb, respectively. After merging ROH segments, 196 consensus ROH regions were detected and used for genome-wide ROH-based association analysis. Thirteen consensus ROH regions were significantly (P < 0.01) associated with growth and feed efficiency traits. Several candidate genes within the significant regions are known for their involvement in growth and body size development, including MEF2A, ADAMTS17, POU3F2, and TYRO3. In addition, we found ten consensus ROH regions, defined as ROH islands, with frequencies over 80% of the population. These islands harbored 12 annotated genes, some of which were related to immune system processes such as DTX3L, PARP9, PARP14, CD86, and HCLS1. This is the first study to explore the associations between homozygous regions with growth and feed efficiency traits in American mink. Our findings shed the light on the effects of homozygosity in the mink genome on growth and feed efficiency traits, that can be utilized in developing a sustainable breeding program for mink.

show abstract

DTX3L/ARTD9 contributes to inflammation of fibroblast-like synoviocytes by increasing STAT1 translocation

Cited by 2 publications

References 23 publications

Functions and Molecular Mechanisms of Deltex Family Ubiquitin E3 Ligases in Development and Disease

Functions and Molecular Mechanisms of Deltex Family Ubiquitin E3 Ligases in Development and Disease

Identification of consensus homozygous regions and their associations with growth and feed efficiency traits in American mink

Contact Info

Product

Resources

About