Du-Zhong (Eucommia ulmoides Oliv.) cortex extract prevent OVX-induced osteoporosis in rats

Zhang, R.; Liu, Z.G.; Li, C.; Hu, Shijie; Liu, L.; Wang, J.P.; Mei, Qibing

doi:10.1016/j.bone.2008.08.127

Cited by 137 publications

(101 citation statements)

References 54 publications

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“…There are more than 20 commonly used herbal medicines occurring in 7 the antiosteoporotic formula. Their chemical constituents and pharmacological activities are 8 summarized in Table 5 18 (EUCE) significantly inhibited OVX-induced decreases in biomechanical quality of the femur 1 and improved bone microarchitecture, and dose dependently inhibited total bone mineral 2 density decreases in the femur caused by OVX and decreased levels of the bone turnover 3 markers OCN, ALP, deoxypyridinoline, and urinary Ca and P excretions (Zhang et al, 2009). 4 EUCE significantly mitigated the decreases in bone volume/tissue volume, connect density, 5…”

Section: The Herb Medicines and Their Chemical Constituents In Tcm Fomentioning

confidence: 99%

Traditional Chinese medicine formulas for the treatment of osteoporosis: Implication for antiosteoporotic drug discovery

Zhang

Han

Huang

et al. 2016

Journal of Ethnopharmacology

197

125

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Section: The Herb Medicines and Their Chemical Constituents In Tcm Fomentioning

confidence: 99%

Traditional Chinese medicine formulas for the treatment of osteoporosis: Implication for antiosteoporotic drug discovery

Zhang

Han

Huang

et al. 2016

Journal of Ethnopharmacology

197

125

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“…Dosis yang diberikan DZCE dapat menghambat penurunan total BMD pada tulang paha yang disebabkan oleh ovariektomi dan disertai dengan penurunan signifikan dalam remodeling tulang, seperti yang dibuktikan adanya penurunan osteokalsin (Zhang et al, 2009).…”

Section: Metodeunclassified

Efek Pemberian Ekstrak Rumput Fatimah (Labisia Pumila) Terhadap Osteokalsin Serum Dan Deoxypiridinolin Urin Pada Tikus Post Ovariektomi

Mariati¹

2017

Jurnal Ilmu Keperawatan dan Kebidanan

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AbstrakTujuan : Penelitian ini bertujuan untuk mengetahui efek pemberian ekstrak rumput fatimah (Labisia pumila) terhadap osteokalsin serum dan deoxypiridinolin urin pada tikus post ovariektomi. Metode : Penelitian ini merupakan penelitian eksperimental, dilakukan di laboratorium Farmakologi dan Fisiologi Fakultas Kedokteran Universitas Brawijaya malang. Menggunakan tikus ovariektomi. Penelitian ini dibagi menjadi 5 kelompok, yaitu 1 kelompok kontrol negatif, 1 kelompok kontrol positif dan 3 kelompok perlakuan pemberian ekstrak rumput fatimah. Pengukuran osteokalsin dan deoxypiridinolin menggunakan elisa kit. Data hasil penelitian dianalisis dengan teknik analisis data.Hasil : Terdapat pengaruh pemberian ekstrak rumput fatimah terhadap penurunan osteokalsin serum dan peningkatan deoxypiridinolin urin pada tikus post ovariektomi. Tidak terdapat hubungan yang signifikan antara ekspresi deoxypiridinolin dengan ekspresi osteokalsin, hal ini menunjukkan bahwa perubahan ekspresi deoxypiridinolin tidak diikuti perubahan pada ekspresi osteokalsin. Pemberian rumput fatimah mampu mempengaruhi perubahan ekspresi deoxypiridinolin sebesar 53,46% dan perubahan ekspresi osteokalsin sebesar 66,97%. Sisanya dijelaskan oleh faktor lain yang tidak terlibat dalam penelitian. Kesimpulan : Pemberian ekstrak rumput fatimah dapat menurunkan osteokalsin serum dan meningkatkan deoxypiridinolin urin pada tikus post ovariektomi.Kata Kunci : Rumput Fatimah, Osteokalsin, Deoxypiridinolin Abstract Objective: This study was intended to investigate the extracurricular effects of serum osteocalcin and urinary deoxypiridinoline in post ovariectomy. Method: This research is an experimental research, conducted in Pharmacology and Physiology laboratory of Faculty of Medicine Universitas Brawijaya malang. Using ovariectomy rats. The study was divided into 5 groups, ie 1 group of negative control, 1 group of positive control and 3 treatment groups from grass fatimah extract. Measurement of osteocalcin and deoxypiridinoline using elisa kit. The result data were analyzed by data analysis technique. Result: There was an effect of giving fatimah grass extract to decrease of serum osteocalcin and increasing urine deoxypiridinolin in post ovariectomy rats. There was no significant association between deoxypiridinolin expression with osteocalcin expression, it showed that deoxypiridinolin expression changes did not follow changes in osteocalcin expression. Grass giving fatimah can change. The rest is explained by other factors not involved in the research. Conclusions: Provision of grass fatimah extract may decrease serum osteocalcin and increase urine deoxypiridinoline in mice after ovariectomy.

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“…The bark of E. ulmoides (Cortex Eucommia) has been traditionally used as an herbal medicine with analeptic, analgesic, sedative, antihypertensive, and diuretic effects in Japan, China, and Korea. In vitro and in vivo studies indicated that the compounds and extracts from Eucommia ulmoides have various pharmacological effects in treating hypertension [10][11][12][13], hyperlipidemia [14,15], diabetes [16], obesity [14,[17][18][19][20], osteoporosis [21][22][23][24][25][26], and lupus-like syndrome [27], and promoting neuroprotection [28,29] and immunoregulation [30]. E. ulmoides leaves and barks have the same iridoid and lignin compound components; therefore, the leaves have been used similarly as the bark, as tonic and antihypertensive.…”

Section: Introductionmentioning

confidence: 99%

Aroma of Eucommia leaf extract (ELE) causes reduced locomotor activity and increased NREM sleep, acting like the partially related factors of oral ELE's effects with locomotor-activity-dependent-increase in NREM- and REM-sleep

Miyazaki¹,

Oikawa²,

Nakamichi³

et al. 2017

Glob Drugs Therap

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Du-Zhong (Eucommia ulmoides Oliv.) cortex extract prevent OVX-induced osteoporosis in rats

Cited by 137 publications

References 54 publications

Traditional Chinese medicine formulas for the treatment of osteoporosis: Implication for antiosteoporotic drug discovery

Traditional Chinese medicine formulas for the treatment of osteoporosis: Implication for antiosteoporotic drug discovery

Efek Pemberian Ekstrak Rumput Fatimah (Labisia Pumila) Terhadap Osteokalsin Serum Dan Deoxypiridinolin Urin Pada Tikus Post Ovariektomi

Aroma of Eucommia leaf extract (ELE) causes reduced locomotor activity and increased NREM sleep, acting like the partially related factors of oral ELE's effects with locomotor-activity-dependent-increase in NREM- and REM-sleep

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