Dual-affinity peptides to generate dense surface coverages of nanoparticles

Re, Julia Del; Blum, Amy Szuchmacher

doi:10.1016/j.apsusc.2014.01.007

Cited by 1 publication

(1 citation statement)

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“…[ 293 ] Particular interests have been directed toward employing peptides to facilitate the assembly/synthesis process due to their chemical flexibility and versatility. [ 294–300 ] Despite the general targeting function of peptide–gold played in gene therapy, [ 20,204,301,302 ] peptide–AuNP conjugates have also been utilized for kinetic studies which revealed details on the effect of protease activity [ 303 ] and aggregation progress [ 304 ] that helps the improvement of existing assays. Most interestingly, peptide–AuNP ensembles have been demonstrated to greatly enhance the transesterification of the p ‐nitrophenyl ester of N‐carboxybenzylphenylalanine (by over two orders of magnitude).…”

Section: Other Applications Of Peptide–gold Hybrid Nanomaterialsmentioning

confidence: 99%

Rational Design of Functional Peptide–Gold Hybrid Nanomaterials for Molecular Interactions

et al. 2020

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Gold nanoparticles (AuNPs) have been extensively used for decades in biosensing‐related development due to outstanding optical properties. Peptides, as newly realized functional biomolecules, are promising candidates of replacing antibodies, receptors, and substrates for specific molecular interactions. Both peptides and AuNPs are robust and easily synthesized at relatively low cost. Hence, peptide–AuNP‐based bio‐nano‐technological approaches have drawn increasing interest, especially in the field of molecular targeting, cell imaging, drug delivery, and therapy. Many excellent works in these areas have been reported: demonstrating novel ideas, exploring new targets, and facilitating advanced diagnostic and therapeutic technologies. Importantly, some of them also have been employed to address real practical problems, especially in remote and less privileged areas. This contribution focuses on the application of peptide–gold hybrid nanomaterials for various molecular interactions, especially in biosensing/diagnostics and cell targeting/imaging, as well as for the development of highly active antimicrobial/antifouling coating strategies. Rationally designed peptide–gold nanomaterials with functional properties are discussed along with future challenges and opportunities.

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