Dual-contrast echo planar imaging with keyhole: application to dynamic contrast-enhanced perfusion studies

Zaitsev, Maxim; d’Arcy, James A.; Collins, David; Leach, Martin O.; Zilles, Karl; Shah, N. Jon

doi:10.1088/0031-9155/50/19/005

Cited by 19 publications

(20 citation statements)

References 27 publications

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“…The current sw-dual-GRE sequence sacrifices coverage. Single-slice techniques are not recommended for quantitative assessment (23). However, a more recent version of the technique exists (23) and allows the measurement of four slices.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the effect of haematocrit‐dependent arterial input functions on the accuracy of pharmacokinetic parameters in dynamic contrast‐enhanced MRI

et al. 2011

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The detection and prognosis of prostate cancer in its early stages are critically important. It is therefore essential to improve the existing dynamic contrast-enhanced MRI (DCE MRI) techniques commonly used for the assessment of the tumour vascular environment. The goal of this study was to describe a method for the estimation of the arterial input function (AIF) in DCE MRI by measuring R(2) * values in the femoral artery of patients with early-stage prostate cancer. The calculation of contrast agent concentrations was based on calibration curves determined in whole blood samples for a range of normal haematocrit (HCT) values (HCT = 0.35-0.525). Individual AIFs corrected for HCT were compared with individual AIFs calibrated with a mean whole blood [R(2)*-Gd-DTPA-BMA] [Gd-DTPA-BMA, gadolinium diethylenetriaminepentaacetate-bis(methylamide) (gadodiamide)] curve at an assumed HCT = 0.44, as well as a population AIF at an assumed HCT = 0.45. The area under the curve of the first-pass bolus ranged between 0.6 min mM at HCT = 0.53 and 1.3 min mM at HCT = 0.39. Significant differences in magnitude at peak contrast agent concentrations (HCT = 0.36, [Gd-DTPA-BMA](max) = 9 ± 0.4 mM; HCT = 0.46, [Gd-DTPA-BMA](max) = 4.0 ± 0.2 mM) were found. Using model-based simulations, the accuracy of the kinetic parameters estimated using individual AIFs corrected for HCT demonstrated that, for the use of individual calibration curves with HCT values differing by more than 10%, K(trans) and k(ep) values were largely underestimated (up to 60% difference for K(trans)). Moreover, blood volume estimates were severely underestimated. Estimates of kinetic parameters in early-stage prostate cancer patients demonstrated that the efflux rate constant (k(ep)) was influenced significantly by the definition of AIF. Regardless of whether an individually calibrated AIF or a population AIF (average of all individually calibrated AIFs) was used, pixel-by-pixel mapping of k(ep) and v(b) in the prostate gland appeared to be more sensitive than with the usual biexponential approach.

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Section: Introductionmentioning

confidence: 99%

Assessment of the effect of haematocrit‐dependent arterial input functions on the accuracy of pharmacokinetic parameters in dynamic contrast‐enhanced MRI

et al. 2011

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“…As the three sampling schemes represent very generic modifications of EPI, the findings are applicable to other EPI‐based time series applications including dynamic contrast enhanced (DCE) MRI, ASL, angiography, for example , diffusion, myocardial perfusion or fMRI, for example . Note that similar trajectories as in the inplace ACS scenario have been presented without parallel imaging, in the context of keyhole acquisitions and with varying acquisition density (without undersampling in k y direction) . The generality of PEAK‐EPI further allows for direct combination with other available advanced imaging techniques, such as multiband excitation.…”

Section: Discussionmentioning

confidence: 92%

“…It has been shown that the acquisition of dual or multiechoes is beneficial for correcting T 1 leakage effects . The achievements of PEAK‐EPI in terms of echo train reduction can be further used as part of multiecho acquisitions.…”

Section: Discussionmentioning

confidence: 99%

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High resolution CBV assessment with PEAK-EPI: k-t-undersampling and reconstruction in echo planar imaging

et al. 2016

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“…For this purpose, this work uses parallel imaging acceleration of EPI with Keyhole (EPIK) for the DSC-MRI acquisition. The EPIK method was proposed in previous works 4,5 and validated at 1.5T 6,7 and recently at 3 T. 8,9 In these previous works, it was shown that EPIK outperforms single-shot EPI in terms of imaging speed and robustness, with respect to geometric distortions, while maintaining comparable performance in tracking dynamically changing MR signals such as those in functional (f )MRI. 6,8,9 Simulations to assess the EPIK method were also performed and the results are given in those works.…”

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confidence: 99%

Dynamic susceptibility contrast parametric imaging using accelerated dual‐contrast echo planar imaging with keyhole

Caldeira

Yun

Silva

et al. 2019

Magnetic Resonance Imaging

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Background Echo planar imaging (EPI) is one of the methods of choice in dynamic susceptibility contrast MRI (DSC‐MRI) because it provides a sufficient temporal resolution. However, the relatively long readout duration of EPI often imposes limitations on increased spatial coverage or the use of multiple contrasts. Purpose To develop a DSC‐MRI method using EPIK (EPI with keyhole) to provide dual‐contrast (TE1 and TE2) information with a higher spatial coverage than EPI. To compare results from the community‐standard EPI method and the proposed EPIK method. Study Type Prospective. Subjects One healthy subject and 17 brain tumor patients. Field Strength/Sequence 3 T/accelerated EPI and dual‐contrast EPIK sequences. Assessment After an initial evaluation using healthy in vivo images, the use of the proposed method for DSC‐MRI was verified with brain tumor patients. The parametric images (eg, CBF and CBV) and arterial input function (AIF), obtained from both the EPI and EPIK, were compared. Statistical Tests The ratio of AIF peak height of the proposed method to that of EPI was computed. The ratio computation was also performed for the time‐to‐peak (TTP) in the AIF curves. From the obtained CBF and CBV maps, the tumor‐to‐brain (TBR) ratio was also calculated for each imaging method and the results were compared. Results For the same temporal resolution (1.5 sec), EPIK yielded dual‐contrast (TEs of 13/33 msec) with an increased spatial coverage (24 slices) and less geometric distortions than EPI; EPI provided single contrast (TE of 32 msec) with 20 slices. The obtained parametric values (eg, AIF peak, TTP, and TBR) had similar characteristics between EPI and the proposed method. Data Conclusion The dual‐contrast data produced by EPIK in DSC‐MRI allowed T1‐corrected parametric images without the need of second contrast injection and an enhanced estimation of the AIF. Level of Evidence: 1 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2019;50:628–640.

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Dual-contrast echo planar imaging with keyhole: application to dynamic contrast-enhanced perfusion studies

Cited by 19 publications

References 27 publications

Assessment of the effect of haematocrit‐dependent arterial input functions on the accuracy of pharmacokinetic parameters in dynamic contrast‐enhanced MRI

Assessment of the effect of haematocrit‐dependent arterial input functions on the accuracy of pharmacokinetic parameters in dynamic contrast‐enhanced MRI

High resolution CBV assessment with PEAK-EPI: k-t-undersampling and reconstruction in echo planar imaging

Dynamic susceptibility contrast parametric imaging using accelerated dual‐contrast echo planar imaging with keyhole

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