Dual-crosslinked, self-healing and thermo-responsive methylcellulose/chitosan oligomer copolymer hydrogels

Yeo, Yong Ho; Park, Won Ho

doi:10.1016/j.carbpol.2021.117705

Cited by 57 publications

(24 citation statements)

References 40 publications

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“…With its homogeneity, high stability over time, and high drug release under NIR light irradiation, the Boc-γ 4 ( R )Phe-γ 4 ( R )Phe-OH + GO hydrogel is the most suitable gel for controlled drug release applications. l -Ascorbic acid has been also incorporated in other types of hydrogels, mainly constituted of pH- or thermo-responsive (bio)polymers [ 50 , 51 ]. The release of the drug was spontaneous at 37 °C [ 51 ], or triggered by changing pH [ 50 ], but it reached lower percentages in comparison to our photoresponsive hydrogels.…”

Section: Resultsmentioning

confidence: 99%

Aromatic Dipeptide Homologue-Based Hydrogels for Photocontrolled Drug Release

et al. 2022

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Peptide-based hydrogels are considered of special importance due to their biocompatibility and biodegradability. They have a wide range of applications in the biomedical field, such as drug delivery, tissue engineering, wound healing, cell culture media, and biosensing. Nevertheless, peptide-based hydrogels composed of natural α-amino acids are limited for in vivo applications because of the possible degradation by proteolytic enzymes. To circumvent this issue, the incorporation of extra methylene groups within the peptide sequence and the protection of the terminal amino group can increase the enzymatic stability. In this context, we investigated the self-assembly capacity of aromatic dipeptides (Boc-α-diphenylalanine and Boc-α-dityrosine) and their β- and γ-homologues and developed stable hydrogels. Surprisingly, only the Boc-diphenylalanine analogues were able to self-assemble and form hydrogels. A model drug, l-ascorbic acid, and oxidized carbon nanotubes (CNTs) or graphene oxide were then incorporated into the hydrogels. Under near-infrared light irradiation, the photothermal effect of the carbon nanomaterials induced the destabilization of the gel structure, which caused the release of a high amount of drug, thus providing opportunities for photocontrolled on-demand drug release.

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Section: Resultsmentioning

confidence: 99%

Aromatic Dipeptide Homologue-Based Hydrogels for Photocontrolled Drug Release

et al. 2022

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“…The hydrogel worked as a PH and enzyme-responsive cargo for the conveyance of gemcitabine drugs to treat pancreatic cancer. Another research group has recently employed methylcellulose/chitosan (MC/CH) dual-crosslinked DAMC and a water-soluble chitosan oligomer (DAMC/CHI–O) copolymer hydrogels for temperature-sensitive delivery of biomolecules as vitamin C ( l -ascorbic acid) and adenosine for cosmetic purposes [ 486 ]. The attractive results of smart/stimuli-responsive self-healable hydrogels have made them highly encouraging to be implemented in various applications in tissue engineering, cosmetics, and drug delivery.…”

Section: Smart/stimuli-responsive Self-healing Hydrogels For Biomedical Applicationsmentioning

confidence: 99%

Smart/stimuli-responsive hydrogels: Cutting-edge platforms for tissue engineering and other biomedical applications

El-Husseiny

Mady

Hamabe

et al. 2022

Materials Today Bio

222

139

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Recently, biomedicine and tissue regeneration have emerged as great advances that impacted the spectrum of healthcare. This left the door open for further improvement of their applications to revitalize the impaired tissues. Hence, restoring their functions. The implementation of therapeutic protocols that merge biomimetic scaffolds, bioactive molecules, and cells plays a pivotal role in this track. Smart/stimuli-responsive hydrogels are remarkable three-dimensional (3D) bioscaffolds intended for tissue engineering and other biomedical purposes. They can simulate the physicochemical, mechanical, and biological characters of the innate tissues. Also, they provide the aqueous conditions for cell growth, support 3D conformation, provide mechanical stability for the cells, and serve as potent delivery matrices for bioactive molecules. Many natural and artificial polymers were broadly utilized to design these intelligent platforms with novel advanced characteristics and tailored functionalities that fit such applications. In the present review, we highlighted the different types of smart/stimuli-responsive hydrogels with emphasis on their synthesis scheme. Besides, the mechanisms of their responsiveness to different stimuli were elaborated. Their potential for tissue engineering applications was discussed. Furthermore, their exploitation in other biomedical applications as targeted drug delivery, smart biosensors, actuators, 3D and 4D printing, and 3D cell culture were outlined. In addition, we threw light on smart self-healing hydrogels and their applications in biomedicine. Eventually, we presented their future perceptions in biomedical and tissue regeneration applications. Conclusively, current progress in the design of smart/stimuli-responsive hydrogels enhances their prospective to function as intelligent, and sophisticated systems in different biomedical applications.

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“…Semi-synthetic derivatives of cellulose, namely, cellulose ethers (high molecular weight compounds produced by replacing the hydrogen atoms of hydroxyl groups in the anhydroglucose units of cellulose with alkyl or substituted alkyl groups, e.g., methylcellulose (MC), ethylcellulose (EC), hydroxyethylcellulose (HEC), hydroxypropyl cellulose (HPC), hydroxypropylmethylcellulose (HPMC), carboxymethyl cellulose (CMC), and sodium carboxymethyl cellulose (NaCMC), play important roles in different types of pharmaceuticals such as extended and delayed-release coated dosage forms, extended and controlled release matrices, osmotic drug delivery systems, bioadhesives and mucoadhesives, compression tablets as compressibility enhancers, liquid dosage forms as thickening agents, and stabilizers, granules, and tablets as binders, semisolid preparations as gelling agents, and many other applications [ 7 , 8 ]. Very recently, various combinations of cellulose ethers, namely, MC plus a water-soluble chitosan oligomer (CS-O) [ 9 ], NaCMC plus HPMC [ 10 ], hydroxyethylcellulose plus gellan gum [ 11 ], CMC plus polyethylene glycol (PEG) [ 12 ], were developed to improve the properties of resulting hydrogels and formulations of various model compounds and drugs (adenosine, l-ascorbic acid, methylene blue, tetracycline, phenylephrine, tropicamide, ketoconazole). In these ways, mechanical and self-healing properties, and drug release of the hydrogels were effectively improved.…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of Polysaccharide-Based Hydrogels: Rheological and Texture Properties and Ibuprofen Release

Mikušová

Ferková

Dominika

et al. 2022

Gels

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Polysaccharides are attractive gelling agents in pharmacy due to their safety, biocompatibility, biodegradability, relatively easy way of preparation, and low price. Due to their variable physical-chemical properties, polysaccharides have potentialities to be used for designing new drug delivery systems for controlled drug release. In this comparative study, rheological and texture properties as well as the in vitro release of model drug ibuprofen (IBU) with 11 polysaccharide-based hydrogels were investigated. The in vitro release of IBU significantly differed between (i) neutral (hydroxy/alkylcelluloses), (ii) anionic (carboxyalkylcellulose and its sodium salt, tragacanth, carrageenan, xanthan gum), and (iii) cationic (chitosans) hydrogels due to different contribution of provided interactions and viscosity within the hydrogel groups. The drug release kinetics of each hydrogel system was evaluated for five kinetic models. Several combinations of cationic hydrogels with neutral or anionic ones were performed to illustrate possibilities of providing modified IBU release profiles. In this context, chitosan was presented as an effective modifier of diffusion profiles for negatively charged drugs formulated into combined polymeric systems, providing their prolonged release. The most appropriate hydrogel for the topical application (i.e., providing favorable rheological and texture properties along with the highest drug release) was selected from a studied series of polysaccharide-based hydrogels.

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Dual-crosslinked, self-healing and thermo-responsive methylcellulose/chitosan oligomer copolymer hydrogels

Cited by 57 publications

References 40 publications

Aromatic Dipeptide Homologue-Based Hydrogels for Photocontrolled Drug Release

Aromatic Dipeptide Homologue-Based Hydrogels for Photocontrolled Drug Release

Smart/stimuli-responsive hydrogels: Cutting-edge platforms for tissue engineering and other biomedical applications

Comparative Study of Polysaccharide-Based Hydrogels: Rheological and Texture Properties and Ibuprofen Release

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