Dual drug loaded coaxial electrospun PLGA/PVP fiber for guided tissue regeneration under control of infection

He, Ping; Zhong, Qi; Ge, Yao; Guo, Zhenzhao; Tian, Jie; Zhou, Ying; Ding, Shan; Li, Hong; Zhou, Changren

doi:10.1016/j.msec.2018.04.014

Cited by 84 publications

(53 citation statements)

References 36 publications

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“…Therefore, the processing time represents a great limit considering a large-scale production. This issue emerged from most of the works focusing on the electrospinning of drug-loaded PVP fibers, in which the solution flow rate ranged between 0.2 and 2 mL/h [23,25,89,96,100,101].…”

Section: Fibersmentioning

confidence: 99%

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The Use of Poly(N-vinyl pyrrolidone) in the Delivery of Drugs: A Review

2020

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Polyvinylpyrrolidone (PVP) is a hydrophilic polymer widely employed as a carrier in the pharmaceutical, biomedical, and nutraceutical fields. Up to now, several PVP-based systems have been developed to deliver different active principles, of both natural and synthetic origin. Various formulations and morphologies have been proposed using PVP, including microparticles and nanoparticles, fibers, hydrogels, tablets, and films. Its versatility and peculiar properties make PVP one of the most suitable and promising polymers for the development of new pharmaceutical forms. This review highlights the role of PVP in drug delivery, focusing on the different morphologies proposed for different polymer/active compound formulations. It also provides detailed information on active principles and used technologies, optimized process parameters, advantages, disadvantages, and final applications.

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Section: Fibersmentioning

confidence: 99%

“…To tune the physical and mechanical properties of electrospun fibers, PVP has been coupled with other polymers in several studies [95,96,[100][101][102][103][104][105][106]. Zein, a protein contained in corn, has been commonly studied as a polymer to be combined with PVP [96,102,103].…”

Section: Fibersmentioning

confidence: 99%

The Use of Poly(N-vinyl pyrrolidone) in the Delivery of Drugs: A Review

2020

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“…As mentioned above, core-sheath nanobers are excellent carriers for loading two different drugs. He et al 102 prepared double drug-loaded nanobers with core-sheath structure by coaxial electrospinning. Naringin and PVP were used as core materials to promote tissue regeneration, and metronidazole and PLGA were used as the shell bers.…”

Section: Drug Delivery Systemmentioning

confidence: 99%

mentioning

confidence: 99%

Application of blocking and immobilization of electrospun fiber in the biomedical field

Ning

Shen

2020

RSC Adv.

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“…For triaxial needle electrospinning, a third polymer solution can be incorporated into the system, it can be used to supply and release two different drugs with the dual delivery system [45][46][47][48], the intermediate layer can act as an isolation layer between the sheath and core materials. Furthermore, triaxial fiber can be formed with varying hydrophobicity and mechanical strength.…”

Section: Electrospinning Nozzle Configuration In Drug Delivery Systemsmentioning

confidence: 99%

Electrospinning: A promising technique for drug delivery systems

Martínez-Pérez

2020

Reviews on Advanced Materials Science

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In the last years, electrospinning has become a technique of intense research to design and fabricate drug delivery systems (DDS), during this time a vast variety of DDS with mainly electrospun polymers and many different active ingredient(s) have been developed, many intrinsic and extrinsic factor have influence in the final system, there are those that can be attributed to the equipment set up and that to the physical-chemical properties of the used materials in the fabrication of DDS. After all, this intense research has generated a great amount of DDS loaded with one or more drugs. In this manuscript a review with the highlights of different kind of systems for drug delivery systems is presented, it includes the basic concepts of electrospinning, types of equipment set up, polymer/drug systems, limitations and challenges that need to be overcome for clinical applications.

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Dual drug loaded coaxial electrospun PLGA/PVP fiber for guided tissue regeneration under control of infection

Cited by 84 publications

References 36 publications

The Use of Poly(N-vinyl pyrrolidone) in the Delivery of Drugs: A Review

The Use of Poly(N-vinyl pyrrolidone) in the Delivery of Drugs: A Review

Application of blocking and immobilization of electrospun fiber in the biomedical field

Electrospinning: A promising technique for drug delivery systems

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