The Use of Poly(N-vinyl pyrrolidone) in the Delivery of Drugs: A Review

Franco, Paola; Marco, Iolanda De

doi:10.3390/polym12051114

Cited by 229 publications

(173 citation statements)

References 139 publications

(306 reference statements)

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“…Different types of PVP are reported to be able to produce high-porosity structures, such as cross-linked PVP, homopolymers (with different molecular weights) or copolymers (Malik et al 2019). Likewise, an enhancement of porosity into biomedical formulations has been reported using PVP as additive (Franco and De Marco 2020). Moreover, replacing some of the hygroscopic VP repeat units with hydrophobic repeat units of VA as is the case of PVP/VA copolymers (PVP/VA) a greater physical stability of biomedical structures can be obtained (Prudic et al 2014).…”

Section: Resultsmentioning

confidence: 99%

Engineered PLGA-PVP/VA based formulations to produce electro-drawn fast biodegradable microneedles for labile biomolecule delivery

et al. 2020

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Biodegradable polymer microneedles (MNs) are recognized as non-toxic, safe and stable systems for advanced drug delivery and cutaneous treatments, allowing a direct intradermal delivery and in some cases a controlled release. Most of the microneedles found in the literature are fabricated by micromolding, which is a multistep thus typically costly process. Due to industrial needs, mold-free methods represent a very intriguing approach in microneedle fabrication. Electro-drawing (ED) has been recently proposed as an alternative fast, mild temperature and one-step strategy to the mold-based techniques for the fabrication of poly(lactic-co-glycolic acid) (PLGA) biodegradable MNs. In this work, taking advantage of the flexibility of the ED technology, we engineered microneedle inner microstructure by acting on the water-in-oil (W/O) precursor emulsion formulation to tune drug release profile. Particularly, to promote a faster release of the active pharmaceutical ingredient, we substituted part of PLGA with poly(1-vinylpyrrolidone-co-vinyl acetate) (PVP/VA), as compared to the PLGA alone in the matrix material. Moreover, we introduced lecithin and maltose as emulsion stabilizers. Microneedle inner structural analysis as well as collagenase entrapment efficiency, release and activity of different emulsion formulations were compared to reach an interconnected porosity MN structure, aimed at providing an efficient protein release profile. Furthermore, MN mechanical properties were examined as well as its ability to pierce the stratum corneum on a pig skin model, while the drug diffusion from the MN body was monitored in an in vitro collagen-based dermal model at selected time points.

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Section: Resultsmentioning

confidence: 99%

Engineered PLGA-PVP/VA based formulations to produce electro-drawn fast biodegradable microneedles for labile biomolecule delivery

et al. 2020

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“…To enhance the miscibility of these two compounds, the inert molecule having both hydrophilic and lipophilic parts should be added. Polyvinylpyrrolidone (PVP) is a biodegradable and biocompatible polymer approved by the US Food and Drug Administration and it is useful for the delivery of various drugs [ 31 ]. The chemical structure of PVP is composed of both hydrophilic and lipophilic moieties [ 32 ].…”

Section: Resultsmentioning

confidence: 99%

Development of Controlled-Release Carbamide Peroxide Loaded Nanoemulgel for Tooth Bleaching: In Vitro and Ex Vivo Studies

et al. 2021

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Burst release of carbamide peroxide (CP) from traditional hydrogels causes severe inflammation to periodontal tissues. The present study explores the development of a novel CP nanoemulgel (CP-NG), an oil-in-water nanoemulsion-based gel in which CP was loaded with a view to controlling CP release. CP solid dispersions were prepared, using white soft paraffin or polyvinylpyrrolidone-white soft paraffin mixture as a carrier, prior to formulating nanoemulsions. It was found that carrier type and the ratio of CP to carrier affected drug crystallinity. Nanoemulsions formulated from the optimized CP solid dispersions were used to prepare CP-NG. It was found that the ratio of drug to carrier in CP solid dispersions affected the particle size and zeta potential of the nanoemulsions as well as drug release behavior and tooth bleaching efficacy of CP-NG. Drug release from CP-NG followed a first-order kinetic reaction and the release mechanism was an anomalous transport. Drug release rate decreased with an increase in solid dispersion carriers. CP-NG obtained from the solid dispersion with a 1:1 ratio of CP to the polymer mixture is suitable for sustaining drug release with high tooth bleaching efficacy and without reduction of enamel microhardness. The developed CP-NG is a promising potential tooth bleaching formulation.

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“…It is also added in formulations for parenteral and ophthalmic administrations [86]. PVP is physiologically inert and considered safe to use in pharmaceutical applications [87]. It can be kept under ordinary conditions without undergoing degradation or decomposition.…”

Section: Polyvinylpyrrolidonementioning

confidence: 99%

Additive Manufacturing of Oral Tablets: Technologies, Materials and Printed Tablets

et al. 2021

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Additive manufacturing (AM), also known as three-dimensional (3D) printing, enables fabrication of custom-designed and personalized 3D constructs with high complexity in shape and composition. AM has a strong potential to fabricate oral tablets with enhanced customization and complexity as compared to tablets manufactured using conventional approaches. Despite these advantages, AM has not yet become the mainstream manufacturing approach for fabrication of oral solid dosage forms mainly due to limitations of AM technologies and lack of diverse printable drug formulations. In this review, AM of oral tablets are summarized with respect to AM technology. A detailed review of AM methods and materials used for the AM of oral tablets is presented. This article also reviews the challenges in AM of pharmaceutical formulations and potential strategies to overcome these challenges.

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The Use of Poly(N-vinyl pyrrolidone) in the Delivery of Drugs: A Review

Cited by 229 publications

References 139 publications

Engineered PLGA-PVP/VA based formulations to produce electro-drawn fast biodegradable microneedles for labile biomolecule delivery

Engineered PLGA-PVP/VA based formulations to produce electro-drawn fast biodegradable microneedles for labile biomolecule delivery

Development of Controlled-Release Carbamide Peroxide Loaded Nanoemulgel for Tooth Bleaching: In Vitro and Ex Vivo Studies

Additive Manufacturing of Oral Tablets: Technologies, Materials and Printed Tablets

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