Dual drug-loaded PLA nanoparticles bypassing drug resistance for improved leukemia therapy

Zhang, Liuliu; Zhu, Huayun; Gu, Yu; Wang, Xiaohua; Wu, Pingping

doi:10.1007/s11051-018-4430-0

Cited by 16 publications

(7 citation statements)

References 31 publications

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“…Enhanced encapsulation and loading capacity were observed. Improved drug uptake and further facilitated an increase in apoptosis rate [ 142 ]. A novel drug delivery system was designed for the treatment of cancer using PLA nanoparticles loaded with PLX4032 which is an anti-cancer drug.…”

Section: Synthetic Biopolymeric Nanoparticlesmentioning

confidence: 99%

Biodegradable Biopolymeric Nanoparticles for Biomedical Applications-Challenges and Future Outlook

Sreena

Nathanael

2023

Materials

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Biopolymers are polymers obtained from either renewable or non-renewable sources and are the most suitable candidate for tailor-made nanoparticles owing to their biocompatibility, biodegradability, low toxicity and immunogenicity. Biopolymeric nanoparticles (BPn) can be classified as natural (polysaccharide and protein based) and synthetic on the basis of their origin. They have been gaining wide interest in biomedical applications such as tissue engineering, drug delivery, imaging and cancer therapy. BPn can be synthesized by various fabrication strategies such as emulsification, ionic gelation, nanoprecipitation, electrospray drying and so on. The main aim of the review is to understand the use of nanoparticles obtained from biodegradable biopolymers for various biomedical applications. There are very few reviews highlighting biopolymeric nanoparticles employed for medical applications; this review is an attempt to explore the possibilities of using these materials for various biomedical applications. This review highlights protein based (albumin, gelatin, collagen, silk fibroin); polysaccharide based (chitosan, starch, alginate, dextran) and synthetic (Poly lactic acid, Poly vinyl alcohol, Poly caprolactone) BPn that has recently been used in many applications. The fabrication strategies of different BPn are also being highlighted. The future perspective and the challenges faced in employing biopolymeric nanoparticles are also reviewed.

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Section: Synthetic Biopolymeric Nanoparticlesmentioning

confidence: 99%

Biodegradable Biopolymeric Nanoparticles for Biomedical Applications-Challenges and Future Outlook

Sreena

Nathanael

2023

Materials

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“…Previous authors have reported similar results for PLGA nanoparticles using PVA as a surfactant. 15,26 The negative signs for coefficients A and D in equation (8) indicate that the particle size decreases with an increase in sonication time (A) and an increase in the volume of organic solvent (D). The negative effect of factor (A) on nanoparticles size can be interpreted in such a way that the basic step of the emulsion solvent evaporation technique is the application of energy to get the emulsion and it is provided by sonication.…”

Section: S1558mentioning

confidence: 99%

“…4 Now the use of biodegradable polymers in the production of polymeric nanoparticles is continuously increasing. 5 Different biodegradable polymers such as poly-(ε-caprolactone), 6 chitosan, 7 polylactic acid (PLA), 8 polyglycolic acid (PGA) and their copolymers poly (lactic-co-glycolic) acid (PLGA), 9 etc. are commonly used for this purpose.…”

Section: Introductionmentioning

confidence: 99%

Formulation, optimization, and characterization of amlodipine besylate loaded polymeric nanoparticles

Chourasiya

Bohrey²,

Pandey

2021

Polymers and Polymer Composites

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The objectives of this work were to formulate and optimize amlodipine besylate loaded polymeric nanoparticles by using factorial design. The emulsion solvent evaporation method was employed successfully to produce the drug loaded polymeric nanoparticles and the optimization was done by the help of the 24 factorial design. The effect of the main preparation variables on the dependent variables such as nanoparticle size and % drug entrapment efficiency was studied for the optimization of the nanoparticles. The characterization of these nanoparticles was done by the different parameters such as interaction between the excipients, size, morphology, zeta potential, % drug entrapment efficiency, % process yield, and in-vitro drug release behavior. FTIR, DLS, TEM, AFM, zeta potential studies, and dialysis bag method were performed for this purpose. The in vitro drug release data were analyzed by different kinetic models to know the release mechanism. The optimized nanoparticles were spherical in shape and showed particle size 91.5 ± 4.3 nm, PDI 0.368 ± 0.014, zeta potential −17.5 mV, % drug entrapment efficiency 74.06 ± 2.1%, and % process yield 78.51 ± 1.8%. The release kinetics studies revealed that drug release from the nanoparticles follow the Korsmeyer–Peppas model.

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“…Polylactic acid has good biodegradability and biocompatibility, 25 which has been approved by the FDA as an excipient for drugs. It is widely used in the medical field, such as nano preparation carriers, nanofiber scaffolds, tissue repair materials, etc.…”

Section: Introductionmentioning

confidence: 99%

Construction of novel amphiphilic chitosan-polylactide graft copolymer nanodroplets for contrast enhanced ultrasound tumor imaging

Wang

Ding

et al. 2021

J Biomater Appl

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In this experiment, a new amphiphilic chitosan-poly(lactide) graft copolymer was synthesized and characterized by IR, 1H-NMR, XRD, TGA. The obtained chitosan-poly (lactide) graft copolymer was used as the matrix material to prepare nanodroplets (NDs) encapsulating with liquid PFP by double-emulsion and solvent evaporation method. The resulting NDs were characterized by photon correlation spectroscopy and transmission electron microscopy (TEM). The biocompatibility was explored by cytotoxicity assay, cell migration assay and blood biochemistry analysis. The experiments of ultrasonic imaging in vitro and in vivo were carried out with a B-mode clinical ultrasound imaging system. The results of FI-IR and 1H-NMR confirmed the successful grafting reaction of polylactic acid(PLLA) to chitosan with a graft rate of 365%. The average size of the NDs was 101.1 ± 2.7 nm, with the polydispersity index (PDI) of 0.127 ± 0.020, and the zeta potential was −31.8 ± 1.5 mV. From the TEM results, NDs were highly dispersed and had a spherical shape with a distinct capsule structure. The NDs exhibited good stability during storage at 4°C. The NDs solution with different concentrations did not affect cell growth and showed good biocompatibility in cytotoxicity, cell migration and blood biochemistry studies. Under the irradiation of ultrasonic waves, the NDs formed an ultrasonic high signal, which could significantly enhance the ultrasound imaging of tumor tissue in vivo. Taken together, the NDs hold great potential for ultrasound imaging as a nanosized contrast agent.

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Dual drug-loaded PLA nanoparticles bypassing drug resistance for improved leukemia therapy

Cited by 16 publications

References 31 publications

Biodegradable Biopolymeric Nanoparticles for Biomedical Applications-Challenges and Future Outlook

Biodegradable Biopolymeric Nanoparticles for Biomedical Applications-Challenges and Future Outlook

Formulation, optimization, and characterization of amlodipine besylate loaded polymeric nanoparticles

Construction of novel amphiphilic chitosan-polylactide graft copolymer nanodroplets for contrast enhanced ultrasound tumor imaging

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