Dual energy CT: preliminary observations and potential clinical applications in the abdomen

Graser, Anno; Johnson, Thorsten R. C.; Chandarana, Hersh; Macari, Michael

doi:10.1007/s00330-008-1122-7

Cited by 437 publications

(278 citation statements)

References 39 publications

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“…The recent introduction of dual-source CT (DSCT) systems has re-enlivened DECT for various clinical indications [9][10][11][12][13][14][15][16][17], owing to the simultaneous data acquisition of two X-ray tube-detector systems at two different X-ray spectra.…”

Section: Discussionmentioning

confidence: 99%

“…This may be explained by the suboptimal separation of X-ray energy spectra without the use of a tin filter which is particularly important for material with only minor differences in X-ray absorption [14]. The tin filter reduces overlap in X-ray energy spectra by increasing the mean photon energy of the 140 kV-tube and, therefore, improves both material differentiation and decomposition [17].…”

Section: Discussionmentioning

confidence: 99%

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Dual-energy CT with tin filter technology for the discrimination of renal lesion proxies containing blood, protein, and contrast-agent. An experimental phantom study

et al. 2010

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PURPOSE: To differentiate proxy renal cystic lesions containing protein, blood, iodine contrast or saline solutions using dual-energy CT (DECT) equipped with a new tin filter technology (TFT). MATERIALS AND METHODS: 70 proxies (saline, protein, blood and contrast agent) were placed in unenhanced and contrast-enhanced kidney phantoms. DECT was performed at 80/140 kV with and without tin filtering. Two readers measured the CT attenuation values in all proxies twice. An 80/140 kV ratio was calculated. RESULTS: All intra-and interobserver agreements were excellent (r = 0.93-0.97; p < 0.001). All CT attenuation values were significantly higher in the enhanced than in the unenhanced setting (p < 0.05; average increase, 12.5 +/-3.6HU), while the ratios remained similar (each, p > 0.05). The CT attenuation of protein, blood and contrast agent solution differed significantly with tin filtering (p < 0.01-0.05). Significant differences were found between the ratios of protein and blood compared to contrast medium solution (each, p < 0.05) and between the ratios of protein and blood in both phantoms with tin filtering (each, p < 0.05). CONCLUSION: DECT allows discrimination between a proxy renal lesion containing contrast agent and lesions containing protein and blood through their different attenuation at 80 kV and 140 kV. Further discrimination between protein and blood containing proxies is possible when using a tin filter.Dual-Energy CT with tin filter technology for the discrimination of renal lesion proxies containing blood, protein, and contrast-agent. An experimental phantom study 1 Abstract Purpose: To differentiate proxy renal cystic lesions containing protein, blood, iodine contrast or saline solutions using dual-energy CT (DECT) equipped with a new tin filter technology (TFT). Materials and Methods:70 proxies (saline, protein, blood and contrast agent) were placed in unenhanced and contrast-enhanced kidney phantoms. DECT was performed at 80/140kV with and without tin filtering. Two readers measured the CT attenuation values in all proxies twice. An 80/140kV ratio was calculated.Results: All intra-and interobserver agreements were excellent (r=0.93-0.97; p<0.001). All CT attenuation values were significantly higher in the enhanced than in the unenhanced setting (p<0.05; average increase, 12.5±3.6HU), while the ratios remained similar (each, p>0.05). The CT attenuation of protein, blood and contrast agent solution differed significantly with tin filtering (p<0.01-0.05). Significant differences were found between the ratios of protein and blood compared to contrast medium solution (each, p<0.05) and between the ratios of protein and blood in both phantoms with tin filtering (each, p<0.05). Conclusion:DECT allows discrimination between a proxy renal lesion containing contrast agent and lesions containing protein and blood through their different attenuation at 80kV and 140kV. Further discrimination between protein and blood containing proxies is possible when using a tin filter.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Dual-energy CT with tin filter technology for the discrimination of renal lesion proxies containing blood, protein, and contrast-agent. An experimental phantom study

et al. 2010

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“…Following technological advances, different generations of CT scanners have been conceived (Goldman, 2007), with recent developments towards dual-energy (Flohr et al, 2006;Graser et al, 2009;Primak et al, 2007) and energy selective CT (Barber et al, 2011). Temporal resolution has improved to less than 100 ms (Flohr et al, 2009).…”

Section: Towards Micro-ctmentioning

confidence: 99%

High-resolution X-ray computed tomography in geosciences: A review of the current technology and applications

Cnudde

Boone

2013

Earth-Science Reviews

1,264

700

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Please cite this article as: Cnudde, V., Boone, M.N., "High-resolution X-ray computed tomography in geosciences: a review of the current technology and applications", Earth Science Reviews (2013Reviews ( ), doi: 10.1016Reviews ( /j.earscirev.2013 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.A C C E P T E D M A N U S C R I P T AbstractHigh-resolution X-ray Computed Tomography (HRXCT) or micro-CT (µCT) is a frequently used non-destructive 3D imaging and analysis technique for the investigation of internal structures of a large variety of objects, including geomaterials. Although the possibilities of X-ray micro-CT are becoming better appreciated in earth science research, the demands on this technique are also approaching certain physical limitations. As such, there remains a lot of research to be done in order to solve all the technical problems that occur when higher demands are put on the technique. In this paper, a review of the principle, the advantages and limitations of X-ray CT itself are presented, together with an overview of some current applications of micro-CT in geosciences. One of the main advantages of this technique is the fact that it is a non-destructive characterization technique which allows 4D monitoring of internal structural changes at resolutions down to a few hundred nanometers. Limitations of this technique are the operator dependency for the 3D image analysis from the reconstructed data, the discretations effects and possible imaging artefacts. Driven by the technological and computational progress, the technique is continuously growing as an analysis tool in geosciences and is becoming one of the standard techniques, as is shown by the large and still increasing number of publications in this research area. It is foreseen that this number will continue to rise, and micro-CT will become an indispensable technique in the field of geosciences.

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“…However it is very difficult to obtain the exact chemical speciation due to the polychromatic nature of the X-ray beam from laboratory X-ray tubes. There are methods, such as dual energy scanning, that can be used to obtain some pseudo chemical sensitivity which are finding increasing application to the medical imaging sector [2]. But still the exact chemical speciation is unavailable.…”

Section: Introductionmentioning

confidence: 99%

3D elemental mapping of materials and structures by laboratory scale spectroscopic X-ray tomography

Egan

Jacques

Wilson

et al. 2017

J. Phys.: Conf. Ser.

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Characterization of voids in shock-loaded Al single crystal by combining X-ray tomography and electron microscopy Chuanshi Hong, Søren Faester, Niels Hansen et al. Abstract. Using a microfocus X-ray tube and pixelated energy-resolving detector it is possible to measure the X-ray absorption spectrum of a material with high spatial resolution. Given sufficient energy resolution in the detector it is possible to detect and identify absorption edges which are characteristic to individual chemical elements. Using computed tomography the three dimensional (3D) internal elemental chemistry of an object can be reconstructed. The application of spectroscopic X-ray tomography is demonstrated by mapping distribution of heavy elements inside a mineralised ore sample. We correlate and validate this data with high resolution X-ray tomography and energy-dispersive X-ray spectroscopy data.

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Dual energy CT: preliminary observations and potential clinical applications in the abdomen

Cited by 437 publications

References 39 publications

Dual-energy CT with tin filter technology for the discrimination of renal lesion proxies containing blood, protein, and contrast-agent. An experimental phantom study

Dual-energy CT with tin filter technology for the discrimination of renal lesion proxies containing blood, protein, and contrast-agent. An experimental phantom study

High-resolution X-ray computed tomography in geosciences: A review of the current technology and applications

3D elemental mapping of materials and structures by laboratory scale spectroscopic X-ray tomography

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