Dual-energy X-ray absorptiometry analysis of body composition in patients affected by OSAS

Bruno, Ernesto; Alessandrini, Marco; Napolitano, Bianca; Padova, Alessandro De; Daniele, Nicola Di; Lorenzo, Antonino De

doi:10.1007/s00405-008-0844-0

Cited by 17 publications

(15 citation statements)

References 25 publications

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“…Few studies have been performed in OSA patients in order to assess the key role of visceral fat distribution in OSA appearance, particularly in elderly people , which is the group where OSA is highly prevalent .…”

Section: Introductionmentioning

confidence: 99%

Association of body fat composition and obstructive sleep apnea in the elderly: A longitudinal study

Martin

Roche

Thomas

et al. 2015

Obesity

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Objective: Obesity and aging are considered risk factors for developing sleep apnea syndrome (OSA). The aim of this study was to determine the association between body fat composition and OSA in healthy elderly subjects examined in a 7-year longitudinal study. Methods: A total of 209 elderly with unrecognized OSA aged 68.3 6 0.8 years underwent a clinical, ambulatory nocturnal respiratory recording, and anthropometric as well as body fat composition assessment by dual-energy X-ray absorptiometry (DEXA) at baseline and follow-up. Results: At study entry, 50.3% of the population showed an apnea1hypopnea index (AHI) <15 with a mean AHI of 16.8 6 11. At follow-up, a reduction of OSA cases (42%) was evident with a mean AHI of 14.6 6 10.2. The DEXA data demonstrated that body mass and total lean mass were reduced at followup, while central and peripheral fat mass showed a slight increase. Correlation analysis between the changes in DEXA measurements versus the changes in AHI and the indices of nocturnal hypoxemia showed an absence of a statistical correlation. Conclusions: The lack of correlation between the DEXA measurement changes and the changes in the AHI confirm our previous data on the absence of a central fat mass effect on OSA in the elderly.

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Section: Introductionmentioning

confidence: 99%

Association of body fat composition and obstructive sleep apnea in the elderly: A longitudinal study

Martin

Roche

Thomas

et al. 2015

Obesity

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“…In addition, previous data also suggest that fat accumulation peripherally such as in the lower extremities is inversely associated with adiposity-related biological factors and risk of metabolic syndrome [9]. The regional obesity also relates to obstructive sleep apnea syndrome (OSAS) as neck fat is one of risk factors of OSAS, and a predictor of the severity of OSAS [10]. Additionally, neck circumference (NC), which mainly reflects the fat deposit around respiratory tract or subcutaneous fat in the neck, is a proxy for upper-body fat and a reliable screening measure for the identification of patients with abnormal fat distribution.…”

Section: Introductionmentioning

confidence: 99%

Head fat is a novel method of measuring metabolic disorder in Chinese obese patients

et al. 2014

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BackgroundBody adiposity, especially ectopic fat accumulation, has a range of metabolic and cardiovascular effects. The aim of this study was to investigate the association between head fat and metabolic values in Chinese obese patients.MethodsData of this cross-sectional study from 66 obese patients were collected. Fat distribution was measured by dual-energy X-ray absorptiometry, and data of body weight, body mass index (BMI), neck circumference (NC), waist circumference (WC), hip circumference (HC), visceral index, basal metabolism (BM), glucose metabolism, lipid levels, uric acid (UA) had been collected.Results1) Head fat was significantly associated with BMI, WC, HC, visceral index, BM, total fat and total fat excluding head fat in both males and females (p < 0.05). Head fat was positively correlated with upper limb fat, trunk fat, weight, fasting plasma C peptide, fasting plasma insulin and UA in women(p < 0.05), and the association was not statistically significant in male (p > 0.05). Head fat was positively corrected with NC in males (p < 0.05) but not females (p > 0.05). There was no significant correlation between head fat and fasting plasma glucose, total choleslerolemia, triglyceridemia, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and free fat acid in either gender (p > 0.05). 2) Receiver operating characteristic analysis showed that a head fat of 1925.6 g and a head fat of 1567.85 g were the best cut-off values to determine subjects with low high-density lipoprotein cholesterol and hyperuricemia respectively.ConclusionsHead fat accumulation was closely associated with increased body fat, hyperinsulinemia, hyperuricemia, and impared lipid profile, suggesting it might be used as an indicator for dyslipidemia and hyperuricemia.

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“…For instance, Bruno et al found a significant relationship between fat mass percentage in the neck region (measured by DEXA) and severity of OSA but no correlation between percent of abdominal fat mass and OSA. 23 When upper airway structure and body fat composition were examined with magnetic resonance imaging in obese children, Arens et al found that the size of upper airway lymphoid tissues correlated with severity of OSA, whereas abdominal visceral fat did not correlate with severity of OSA. 24 Magnetic resonance imaging used to compare fat distribution in men and women also suggested a role for the pattern of fat deposition adjacent to the upper airway for the development of OSA rather than obesity per se.…”

Section: Sleep Parameters Vs Obesity Parametersmentioning

confidence: 99%

Body Fat Composition: A Predictive Factor for Sleep Related Breathing Disorder in Obese Children

Bhatia

Lesser

Oliveira

et al. 2015

Journal of Clinical Sleep Medicine

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Introduction:The association between body fat composition as measured by dual energy x-ray absorptiometry (DEXA) scanning and pediatric sleep related breathing disorder (SRBD) is not well established. We investigated the relationship between body mass index (BMI) and DEXA parameters and their association with SRBD in obese children. Patients and Methods: Overnight polysomnography was performed on obese/overweight children (10-17 years) with habitual snoring. Total body fat mass (g), trunk fat mass (g), total body % fat, and trunk % fat were determined by DEXA. Results: Forty-one subjects were studied. Logarithm (Log) total arousal index correlated with BMI (p < 0.01, r = 0.473), total body fat mass (p < 0.05, r = 0.331), and trunk fat mass (p < 0.05, r = 0.319). Log desaturation index correlated with BMI (p < 0.05, r = 0.313), total body fat mass (p < 0.05, r = 0.375), and trunk fat mass (p < 0.05, r = 0.391), whereas obstructive apnea hypopnea index (OAHI) did not. In males 10-12 years, there was a signifi cant correlation between Log total arousal index and obesity parameters, but not for males aged 13-17 years. BMI correlated with DEXA parameters in all subjects: total body fat mass (p < 0.001, r = 0.850); total body % fat (p < 0.01, r = 0.425); trunk fat mass (p < 0.001, r = 0.792) and trunk % fat (p < 0.05, r = 0.318) and in 10-12 year old males. This relationship was not signifi cant in males aged 13-17 years. Conclusions: Total body fat mass and trunk fat mass as well as BMI correlated with total arousal index and desaturation index. BMI correlated with DEXA parameters in 10-12 year old males but not in 13-17 year old males. The value of using DEXA scanning to study the relationship between obesity and SRBD may depend on age and pubertal stage. Keywords: pediatric obesity, body mass index, body fat composition, DEXA scan, sleep related breathing disorder, pediatric obstructive sleep apnea Citation: Bhatia R, Lesser DJ, Oliveira FG, Tran WH, Keens TG, Khoo MC, Davidson Ward SL. Body fat composition: a predictive factor for sleep related breathing disorder in obese children.

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Dual-energy X-ray absorptiometry analysis of body composition in patients affected by OSAS

Cited by 17 publications

References 25 publications

Association of body fat composition and obstructive sleep apnea in the elderly: A longitudinal study

Association of body fat composition and obstructive sleep apnea in the elderly: A longitudinal study

Head fat is a novel method of measuring metabolic disorder in Chinese obese patients

Body Fat Composition: A Predictive Factor for Sleep Related Breathing Disorder in Obese Children

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