2022
DOI: 10.1016/j.cej.2022.136795
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Dual-enzyme catalytic nanosystem-mediated ATP depletion strategy for tumor elimination via excessive autophagy pathway

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Cited by 12 publications
(5 citation statements)
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“…Even the significant and hostile depletion of ATP forces the cells toward necrotic changes rather than apoptosis and/or autophagic death [ 84 ]. Rapid ATP depletion activates excessive autophagy flux, which exceeds the degradation capacity of lysosomes, resulting in the accumulation of autophagosomes and cell death [ 8 , 85 ]. It should not be forgotten that some treatment protocols are not applicable in in vivo conditions with prolonged fasting.…”
Section: If and Autophagymentioning
confidence: 99%
See 1 more Smart Citation
“…Even the significant and hostile depletion of ATP forces the cells toward necrotic changes rather than apoptosis and/or autophagic death [ 84 ]. Rapid ATP depletion activates excessive autophagy flux, which exceeds the degradation capacity of lysosomes, resulting in the accumulation of autophagosomes and cell death [ 8 , 85 ]. It should not be forgotten that some treatment protocols are not applicable in in vivo conditions with prolonged fasting.…”
Section: If and Autophagymentioning
confidence: 99%
“…Despite the protective role of autophagy on injured cells, abnormal or excessive autophagic responses cause several pathological outcomes via the stimulation of programmed cell death such as apoptosis, pyroptosis, etc. [ [8] , [9] , [10] , [11] ]. Likewise, a severe reduction in autophagy activity can contribute to diverse pathological conditions such as genome instability, anaplastic changes, infection, premature aging, and metabolic disease [ [12] , [13] , [14] , [15] , [16] ].…”
Section: Introductionmentioning
confidence: 99%
“…Autophagy is a programmed cytoprotective mechanism initiated by cells in response to stressful conditions such as hypoxia and nutrient deficiencies for the recycling and degradation of functionally impaired cellular components or invading foreign substances. To fulfill the exuberant metabolic demands of tumors, to evade and resist attack, and to allow their growth and proliferation, tumor cells exhibit higher autophagic activity than normal cells. , It has been found that tumor growth and invasion are genetically related to autophagy in tumor regions . Traditional chemotherapy usually induces apoptosis in tumor cells and, meanwhile, the basal levels of autophagy .…”
Section: Introductionmentioning
confidence: 99%
“…However, autophagy is a double-edged sword. When the activation of autophagy exceeds a certain limit, autophagic cell death is induced and further promotes apoptosis. , As an inhibitor of mitochondrial complex V, RES inhibits intracellular power sources, resulting in the lack of ATP energy, which increases the autophagy level. , The elevated autophagy is expected to break the autophagy balance of tumor cells and induce autophagic cell death, thereby expanding the PDT effect.…”
Section: Introductionmentioning
confidence: 99%
“…30,31 As an inhibitor of mitochondrial complex V, RES inhibits intracellular power sources, resulting in the lack of ATP energy, which increases the autophagy level. 32,33 The elevated autophagy is expected to break the autophagy balance of tumor cells and induce autophagic cell death, thereby expanding the PDT effect.…”
Section: Introductionmentioning
confidence: 99%