2012
DOI: 10.1155/2012/187080
|View full text |Cite
|
Sign up to set email alerts
|

Dual Functions of the C5a Receptor as a Connector for the K562 Erythroblast-Like Cell-THP-1 Macrophage-Like Cell Island and as a Sensor for the Differentiation of the K562 Erythroblast-Like Cell during Haemin-Induced Erythropoiesis

Abstract: The transcriptional nuclear factor binding to the Y box of human leukocyte antigen genes (NF-Y) for the C5a receptor (C5aR) gene is active in erythroblasts. However, the roles of the C5aR in erythropoiesis are unclear. We have previously demonstrated that apoptotic cell-derived ribosomal protein S19 (RP S19) oligomers exhibit extraribosomal functions in promoting monocyte chemotaxis and proapoptosis via the C5aR without receptor internalisation. In contrast to the extraribosomal functions of the RP S19, a proa… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
4
0

Year Published

2013
2013
2020
2020

Publication Types

Select...
5

Relationship

1
4

Authors

Journals

citations
Cited by 5 publications
(4 citation statements)
references
References 37 publications
0
4
0
Order By: Relevance
“…They concluded that the C3a–C3aR and C5a–C5aR axes modulate the interaction of erythroid progenitors with the haematopoietic environment and play a significant role in developmental trafficking of erythroid cells in BM. Nishiura et al 13 . found that erythroblast‐like cells derived from human erythroleukaemia K562 cells express C5a receptor.…”
Section: Figurementioning
confidence: 99%
See 1 more Smart Citation
“…They concluded that the C3a–C3aR and C5a–C5aR axes modulate the interaction of erythroid progenitors with the haematopoietic environment and play a significant role in developmental trafficking of erythroid cells in BM. Nishiura et al 13 . found that erythroblast‐like cells derived from human erythroleukaemia K562 cells express C5a receptor.…”
Section: Figurementioning
confidence: 99%
“…found that erythroblast‐like cells derived from human erythroleukaemia K562 cells express C5a receptor. When bound to ribosomal protein (RP) S19, the C5a receptor may promote differentiation of erythroid bodies in the BM 15 . Chen et al 16 .…”
Section: Figurementioning
confidence: 99%
“…However, the roles of the erythroblast stagespecific activation of pro-apoptotic signals and the formation of erythroblast-macrophage islands under normal conditions are not clearly understood. Recently, we found that human erythroleukemia K562 cells synthesize C5aRs de novo and release RP S19 polymers during hemin-induced erythropoiesis [48]. The K562 cell differentiation is stopped before the formation of erythroblastlike cell-macrophage islands by either neutralization of the RP S19 polymer with an anti-RP S19 antibody or blockade of the C5aR with C5aR antagonistic peptides.…”
Section: An Alternative Signal Transduction Pathway Mediated By the Ementioning
confidence: 99%
“…The LFA-1 functions as an adhesion molecule, binding to intercellular adhesion molecule 1 on antigen-presenting cells for promoting proliferation/differentiation of T cells. We are interested in the different signal transduction pathways mediated by the same LFA-1 but in a cell type-specific manner, as previously shown for the C5aR [39,48]. It is very complicated, because the oral manifestation appears to change with the type and quantity of bacteria in a circadian rhythm.…”
Section: The C5ar In Periodontitismentioning
confidence: 99%