2022
DOI: 10.1021/acsnano.2c06848
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Dual-Modal Imaging and Synergistic Spinal Tumor Therapy Enabled by Hierarchical-Structured Nanofibers with Cascade Release and Postoperative Anti-adhesion

Abstract: Most treatments for spinal cancer are accompanied by serious side effects including subsequent tumor recurrence, spinal cord compression, and tissue adhesion, thus a highly effective treatment is crucial for preserving spinal and neurological functionalities. Herein, trilayered electrospun doxorubicin@bovine serum albumin/poly­(ε-caprolactone)/manganese dioxide (DOX@BSA/PCL/MnO2) nanofibers with excellent antiadhesion ability, dual glutathione/hydrogen peroxide (GSH/H2O2) responsiveness, and cascade release of… Show more

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Cited by 15 publications
(12 citation statements)
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“…Hence, some efforts were devoted to using superhydrophobic materials. Qian et al [ 194 ] prepared an electrospun DOX@bovine serum albumin/poly(ε-caprolactone)/MnO 2 (DOX@BSA/PCL/MnO 2 ) membrane. The membrane exhibited hydrophobic characteristics because of the hydrophobic PCL spinning, which had been demonstrated to play a crucial role in the significant spinal anti-adhesion property of membrane.…”
Section: Possible Strategies For Preventing Adhesion By Using Biomate...mentioning
confidence: 99%
See 1 more Smart Citation
“…Hence, some efforts were devoted to using superhydrophobic materials. Qian et al [ 194 ] prepared an electrospun DOX@bovine serum albumin/poly(ε-caprolactone)/MnO 2 (DOX@BSA/PCL/MnO 2 ) membrane. The membrane exhibited hydrophobic characteristics because of the hydrophobic PCL spinning, which had been demonstrated to play a crucial role in the significant spinal anti-adhesion property of membrane.…”
Section: Possible Strategies For Preventing Adhesion By Using Biomate...mentioning
confidence: 99%
“…Constructing double-layer or multilayer materials with excellent structural stability is the most used strategy. Among them, Janus porous hydrogel [ 175 , 288 ], hydrogel-electrospinning system [ 177 ], electrospinning-electrospinning system [ 334 ], electrospinning-cast film system [ 335 ], electrospinning-sheet system [ 336 , 337 ], sponge-hydrogel system [ 338 ], aerogel-electrospinning system [ 339 ] and layer-by-layer surface coating [ 340 ] show superiority and need wider application and research. In addition, the surface coating technology such as “hydrogel skin” [ 219 , 341 ] exhibited priority.…”
Section: Summary and Prospectmentioning
confidence: 99%
“…It also interacts with GSH and H 2 O 2 to generate Mn 2+ and •OH to achieve CDT (Figure 10b). [118] In addition to MnO 2 , [140][141][142][143] other manganese oxide-based catalytic nanoplatforms such as MnO and Mn 3 O 4 can also undergo Fenton-like reactions. [119][120]144]…”
Section: Mn-based Catalytic Nanoplatformmentioning
confidence: 99%
“…In parallel, a growing number of research studies have concentrated on the integration of imaging-guided diagnosis and precise treatment in the field of theranostic nanotechnology. Nanotechnology could improve stability, tumor targeting capability, and biocompatibility of agents, as well as further enhance the image contrast between tumor lesions and normal tissues. , Different imaging techniques possess their unique pros and cons, so it is common to combine two or more imaging modalities to improve diagnostic accuracy and sensitivity. Magnetic resonance imaging (MRI) is the most powerful noninvasive imaging technique for its superb spatial resolution, unlimited penetration depth, and nonionizing radiation damage . However, MRI still suffers from low sensitivity due to the poor tumor targeting and accumulation of Gd-DTPA, the most commonly used MRI T 1 contrast agent (CA), which limits the wide biomedical applications for diagnosis at the early stage of tumors. Fluorescence imaging (FI), another widely used imaging technique, has high sensitivity and specificity but low tissue resolution and restricted tissue penetration depth, which restricts its imaging application in the clinical field. , Hence, a nano-CA combining FI and MRI not only overcomes the inherent limitations of each imaging technique but also prevents false-positive diagnoses that can occur with a single imaging modality.…”
Section: Introductionmentioning
confidence: 99%