Dual MRI T1 and T2(⁎) contrast with size-controlled iron oxide nanoparticles

Ferrites as magnetic fluids for hyperthermia and MRI contrast agents

“…The increase of temperature is something that is entirely related to the concentration of the magnetic nanoparticles. For that reason, in the SLP formula, there is a correction with the magnetic mass for the samples (23). As expected, SLP values also increase according to the hysteresis curves at room temperature, meaning that ZnMn has the lowest SLP values, and ZnMn-Fe 1h has the largest one.…”

Iron Oxide Based Nanoparticles for Multimodal Imaging and Magnetoresponsive Therapy

“…178−181 Because the T 2 contrast effect of iron oxide nanoparticles is not sacrificed for UTE, the benefits of dual T 1 -and T 2 -weighted imaging can be combined. 179,180 Another approach for dual-mode MRI imaging is to tailor iron oxide nanoparticles by incorporating paramagnetic metal ions, such as Gd 3+ and Mn 2+ (Figure 7). 182 In this case, the direct contact of magnetic nanoparticles and paramagnetic ions should be avoided because the strong magnetic fields generated by T 2 contrast materials disturb the T 1 relaxation processes, resulting in signal attenuation.…”

UTE-ΔR2-ΔR2* combined MR whole-brain angiogram using dual-contrast superparamagnetic iron oxide nanoparticles

“…Although gradient echo‐based Δ R 2 * MRA is expected to provide higher sensitivity of finer vessels with limited spatial resolution, Δ R 2 MRA is generally preferred; erroneous signal dephasing in brain regions near the air–tissue interface and vessel size overestimation are generally perceived to be the critical limitations of Δ R 2 * MRA in rodent brain angiography applications . Consequently, quantitative comparisons of different MRAs on the same subject are necessary, and possible synergistic mergers are attractive, but neither systematic assessments nor complementary combinations of different MRAs have been discussed with regard to brain angiography applications .…”