Dual-network hydrogel based on ionic nano-reservoir for gastric perforation sealing

Yuan, Ye; Wu, Hao; Ren, Xueyang; Wang, Jianwu; Liu, Ruiqing; Hu, Benhui; Gu, Ning

doi:10.1007/s40843-021-1849-3

Cited by 16 publications

(12 citation statements)

References 55 publications

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“…The modulator also exhibits a rapid response and recovery time of 4.8 and 10.2 ms that are comparable to the skin due to the mechanical robustness and excellent elastic resilience (Figure S13). − …”

Section: Resultsmentioning

confidence: 99%

In-Memory Tactile Sensor with Tunable Steep-Slope Region for Low-Artifact and Real-Time Perception of Mechanical Signals

Chen

Ren

et al. 2023

ACS Nano

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A tactile sensor needs to perceive static pressures and dynamic forces in real-time with high accuracy for early diagnosis of diseases and development of intelligent medical prosthetics. However, biomechanical and external mechanical signals are always aliased (including variable physiological and pathological events and motion artifacts), bringing great challenges to precise identification of the signals of interest (SOI). Although the existing signal segmentation methods can extract SOI and remove artifacts by blind source separation and/or additional filters, they may restrict the recognizable patterns of the device, and even cause signal distortion. Herein, an in-memory tactile sensor (IMT) with a dynamically adjustable steep-slope region (SSR) and nanocavity-induced nonvolatility (retention time >1000 s) is proposed on the basis of a machano-gated transistor, which directly transduces the tactile stimuli to various dope states of the channel. The programmable SSR endows the sensor with a critical window of responsiveness, realizing the perception of signals on demand. Owing to the nonvolatility of the sensor, the mapping of mechanical cues with high spatiotemporal accuracy and associative learning between two physical inputs are realized, contributing to the accurate assessment of the tissue health status and ultralow-power (about 25.1 μW) identification of an occasionally occurring tremor.

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Section: Resultsmentioning

confidence: 99%

In-Memory Tactile Sensor with Tunable Steep-Slope Region for Low-Artifact and Real-Time Perception of Mechanical Signals

Chen

Ren

et al. 2023

ACS Nano

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Section: Gi Perforationmentioning

confidence: 99%

“…Sodium alginate (SA) physically crosslinked with calcium ions (Ca 2+ ) serves as a second network in a poly(acrylamide) (PAM)-based covalent network to enhance energy dissipation in multiple instances [ 52 , 67 ]. One of the challenges for GI perforation repair lies in the excessive swelling of hydrogels, which may cause a mismatch strain between the hydrogel and the tissue, thereby reducing the overall adhesion performance [ 67 ]. To address this issue, nano-hydroxyapatites are embedded into the PAM-based network to function as ionic nano-reservoirs and gradually release Ca 2+ in acidic environments, building a second SA-based network to inhibit swelling of the hydrogel in gastric juice [ 67 ].…”

Section: Gi Perforationmentioning

confidence: 99%

“…One of the challenges for GI perforation repair lies in the excessive swelling of hydrogels, which may cause a mismatch strain between the hydrogel and the tissue, thereby reducing the overall adhesion performance [ 67 ]. To address this issue, nano-hydroxyapatites are embedded into the PAM-based network to function as ionic nano-reservoirs and gradually release Ca 2+ in acidic environments, building a second SA-based network to inhibit swelling of the hydrogel in gastric juice [ 67 ]. Silk fibroin (SF) is a natural multi-domain protein that is also being incorporated into IPN hydrogel adhesives owing to its superior strength and stretchability [ 68 ].…”

Section: Gi Perforationmentioning

confidence: 99%

“…However, the hydrogel solution must show good injectability, quick gelation, and ease of operation. A multi-step gelation process that involves light administration and extra reactants may require specially designed delivery devices [ 54 , 67 ]. Patch-type hydrogels are designed for perforation sealing during open surgery and should stick instantly upon application.…”

Section: Gi Perforationmentioning

confidence: 99%

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Advances in Hydrogel Adhesives for Gastrointestinal Wound Closure and Repair

Grinstaff

2023

Gels

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Millions of individuals undergo gastrointestinal (GI) tract surgeries each year with common postoperative complications including bleeding, perforation, anastomotic leakage, and infection. Today, techniques such as suturing and stapling seal internal wounds, and electrocoagulation stops bleeding. These methods induce secondary damage to the tissue and can be technically difficult to perform depending on the wound site location. To overcome these challenges and to further advance wound closure, hydrogel adhesives are being investigated to specifically target GI tract wounds because of their atraumatic nature, fluid-tight sealing capability, favorable wound healing properties, and facile application. However, challenges remain that limit their use, such as weak underwater adhesive strength, slow gelation, and/or acidic degradation. In this review, we summarize recent advances in hydrogel adhesives to treat various GI tract wounds, with a focus on novel material designs and compositions to combat the environment-specific challenges of GI injury. We conclude with a discussion of potential opportunities from both research and clinical perspectives.

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A Nonswelling Hydrogel with Regenerable High Wet Tissue Adhesion for Bioelectronics

et al. 2023

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Reducing the swelling of tissue‐adhesive hydrogels is crucial for maintaining stable tissue adhesion and inhibiting tissue inflammation. However, reported strategies for reducing swelling always result in a simultaneous decrease in the tissue adhesive strength of the hydrogel. Furthermore, once the covalent bonds break in the currently reported hydrogels, they cannot be rebuilt, and the hydrogel loses its tissue adhesive ability. In this work, a nonswelling hydrogel (named as “PAACP”) possessing regenerable high tissue adhesion is synthesized by copolymerizing and crosslinking poly(vinyl butyral) with acrylic acid, gelatin, and chitosan‐grafted N‐acetyl‐l‐cysteine. The tissue adhesive strength of the obtained PAACP reaches 211.4 kPa, which is approximately ten times higher than that of the reported nonswelling hydrogels, and the hydrogel can be reused for multiple cycles. The as‐prepared hydrogel shows great potential in soft bioelectronics, as muscle fatigue is successfully monitored via the electrode array and strain sensor integrated on PAACP substrates. The success of these bioelectronics offers potential applicability in the long‐term diagnosis of muscle‐related health conditions and prosthetic manipulations.

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Dual-network hydrogel based on ionic nano-reservoir for gastric perforation sealing

Cited by 16 publications

References 55 publications

In-Memory Tactile Sensor with Tunable Steep-Slope Region for Low-Artifact and Real-Time Perception of Mechanical Signals

In-Memory Tactile Sensor with Tunable Steep-Slope Region for Low-Artifact and Real-Time Perception of Mechanical Signals

Advances in Hydrogel Adhesives for Gastrointestinal Wound Closure and Repair

A Nonswelling Hydrogel with Regenerable High Wet Tissue Adhesion for Bioelectronics

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