Dual photoacoustic/ultrasound multi-parametric imaging from passion fruit-like nano-architectures

Armanetti, Paolo; Pocoví‐Martínez, Salvador; Flori, Alessandra; Avigo, Cinzia; Cassano, Domenico; Menichetti, Luca; Voliani, Valerio

doi:10.1016/j.nano.2018.05.007

Cited by 42 publications

(46 citation statements)

References 26 publications

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“…It is worth to remember here that the quantitative assessment of metal clearance has been conducted on standard NAs comprising gold USNPs, in order to focus on the biodegradation and metal excretion. On the other hand, due to the robustness of the synthetic protocol, moieties of interest such as dyes or drugs can be straightforwardly incorporated in NAs in order to produce biodegradable all‐in‐one nanoplatforms . Biodistribution and excretion behaviors of nanomaterials are strictly dependent on their HD rather than their physical size.…”

Section: Resultsmentioning

confidence: 99%

“…The preservation of kidneys even after 10 d from NAs administration is encouraging in the perspective of complete metal excretion over a longer timeframe. Furthermore, these findings are of particular interest as the tested amount of NAs should be suitable for theranostic applications, among which enhanced chemo(radio)therapy and nonionizing imaging diagnosis …”

Section: Resultsmentioning

confidence: 99%

“…Moreover, we have recently demonstrated that NAs can be employed as effective contrast agents for US imaging because of the hollow structure. Indeed, NAs generate an enhanced US echo signal due to the concurrent presence of a double silica layer (interior and exterior surfaces of the shell) and to the polymer content, that result in a double impedance mismatch . Furthermore, the extreme versatility and reproducibility of the synthetic protocol was discussed and the remarkable biocompatibility of NAs was assessed in relevant Zebrafish models .…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, NAs generate an enhanced US echo signal due to the concurrent presence of a double silica layer (interior and exterior surfaces of the shell) and to the polymer content, that result in a double impedance mismatch. [14] Furthermore, the extreme versatility and reproducibility of the synthetic protocol was discussed and the remarkable biocompatibility of NAs was assessed in relevant Zebrafish models. [10,15,16] Overall, NAs result as appealing candidates for the translation of metal nanotheranostic to clinics.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Biodegradable Ultrasmall‐in‐Nano Gold Architectures: Mid‐Period In Vivo Distribution and Excretion Assessment

Cassano

Summa

Pocoví‐Martínez

et al. 2018

Part & Part Syst Charact

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The persistence of metals in the body after the designed theranostic action has hampered the clinical translation of noble metal nanoparticles (NPs) to clinics. Therefore, the appealing behaviors of NPs for healthcare applications are still on the bench‐side. Here, quantitative evaluation in healthy murine models show that gold comprised in passion fruit‐like nanoarchitectures (NAs) are excreted daily over a 10 d period by both renal and biliary pathways after biodegradation to the building blocks. Furthermore, histological analyses confirm the absence of nephrotoxicity and the remarkable biocompatibility of NAs up to the higher tested amount of 150 mg kg−1. These in vivo findings demonstrate that NAs are the first full‐inorganic disassembling nanoplatforms exhibiting a noticeable excretion rate from model organisms. Such results are a significant step in bringing noble metal nanotheranostics to the forefront of cancer treatments once again.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Biodegradable Ultrasmall‐in‐Nano Gold Architectures: Mid‐Period In Vivo Distribution and Excretion Assessment

Cassano

Summa

Pocoví‐Martínez

et al. 2018

Part & Part Syst Charact

Self Cite

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“…Gold nanoparticles (AuNPs) are commonly used nanoparticles which have been widely employed in photoacoustic imaging, catalysis, photothermal therapy and targeted drug delivery [1,2,3,4]. The chemical reduction method is the most widely used to prepare AuNPs [5]; however, some chemical organic compounds including thiol and sodium borohydride are toxic to the environment [6,7].…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis of Gold Nanoparticles Using Carrageenan Oligosaccharide and Their In Vitro Antitumor Activity

et al. 2018

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Gold nanoparticles (AuNPs) have been widely used in catalysis, photothermal therapy, and targeted drug delivery. Carrageenan oligosaccharide (CAO) derived from marine red algae was used as a reducing and capping agent to obtain AuNPs by an eco-friendly, efficient, and simple synthetic route for the first time. The synthetic conditions of AuNPs were optimized by response surface methodology (RSM), and the CAO-AuNPs obtained were demonstrated to be ellipsoidal, stable and crystalline by means of transmission electron microscopy (TEM), scanning electron microscopy (SEM) and X-ray diffraction (XRD). The CAO-AuNPs showed localized surface plasmon resonance (LSPR) oscillation at about 530 nm with a mean diameter of 35 ± 8 nm. The zeta potential of CAO-AuNPs was around −20 mV, which was related to the negatively charged CAO around AuNPs. The CAO-AuNPs exhibited significant cytotoxic activities to HCT-116 and MDA-MB-231 cells, which could be a promising nanomaterial for drug delivery.

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Biodegradable Silica‐Based Nanoparticles with Improved and Safe Delivery of Protoporphyrin IX for the In Vivo Photodynamic Therapy of Breast Cancer

Lyles

Tarannum

Mena

et al. 2020

Advanced Therapeutics

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Silica-based nanoplatforms are highly versatile and attractive delivery systems for cancer treatment. These platforms have been used for the effective delivery of pharmacological agents in preclinical settings. Though silicon oxide is found naturally in the human body, a major limitation associated with silica-based nanoparticles is their slow biodegradability. Therefore, the potential risks related to the longer bioaccumulation of these materials can be significant. In this work, the synthesis and application of a novel silica-based nanoplatform, polysilsesquioxane nanoparticles (PSilQ NPs) is reported. The developed PSilQ material contains stimuli-responsive properties, and improves biodegradability for the efficient delivery of a clinically relevant photosensitizer, protoporphyrin IX. Herein, it is demonstrated that the PSilQ nanoplatform is biocompatible and exhibits enhanced biodegradability in an immune-competent mouse model. In addition, PSilQ NPs show phototherapeutic efficiency for reducing the tumor burden in an orthotopic model of triple-negative breast cancer. These results may pave the way for the future clinical evaluation of this silica-based nanoplatform.

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Dual photoacoustic/ultrasound multi-parametric imaging from passion fruit-like nano-architectures

Cited by 42 publications

References 26 publications

Biodegradable Ultrasmall‐in‐Nano Gold Architectures: Mid‐Period In Vivo Distribution and Excretion Assessment

Biodegradable Ultrasmall‐in‐Nano Gold Architectures: Mid‐Period In Vivo Distribution and Excretion Assessment

Green Synthesis of Gold Nanoparticles Using Carrageenan Oligosaccharide and Their In Vitro Antitumor Activity

Biodegradable Silica‐Based Nanoparticles with Improved and Safe Delivery of Protoporphyrin IX for the In Vivo Photodynamic Therapy of Breast Cancer

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