Dual red-NIR luminescent Eu Yb heterolanthanide nanoparticles as promising basis for cellular imaging and sensing

Terbium(III)-thiacalix[4]arene nanosensor for highly sensitive intracellular monitoring of temperature changes within the 303–313 K range

“…The luminescent nanoparticles with core-shell morphology, where the core results from the solvent-induced nanoprecipitation of lanthanide complexes, while the hydrophilic shell derives from the deposition of the polyelectrolytes, represent very promising alternative to the polymeric nanoparticles doped by the lanthanide complexes 4,6 . The main advantage of this morphology is the facile and easy way of conversion of the molecular lanthanide complexes into the aqueous colloids.…”

“…Careful monitoring of these factors, in turn, is a prerequisite for design of novel nanoparticles with high thermo-sensitivity and good cellular uptake behavior, able to allow the luminescence response monitored in the intracellular space on the gentle heating of the cell samples. In this regard, calix [4]arene, calix [4]resorcinarene and thiacalix [4]arene derivatives provide the optimal ligand environment of Tb 3+ ions for both efficient Tb 3+ -centered luminescence and facile conversion into the aqueous luminescent colloids with high colloid stability 4,37 . The documented colloids were revealed as efficient fluorescent contrast agents with good cellular uptake behavior 4 .…”

“…In this regard, calix [4]arene, calix [4]resorcinarene and thiacalix [4]arene derivatives provide the optimal ligand environment of Tb 3+ ions for both efficient Tb 3+ -centered luminescence and facile conversion into the aqueous luminescent colloids with high colloid stability 4,37 . The documented colloids were revealed as efficient fluorescent contrast agents with good cellular uptake behavior 4 . Moreover, some thiacalix [4]arene derivatives has been recently reported 38,39 as the appropriate ligand environment of Tb 3+ ions to generate the Tb 3+ -centered luminescence exhibiting the temperature responsive behavior in physiological temperature range.…”

“…The documented colloids were revealed as efficient fluorescent contrast agents with good cellular uptake behavior 4 . Moreover, some thiacalix [4]arene derivatives has been recently reported 38,39 as the appropriate ligand environment of Tb 3+ ions to generate the Tb 3+ -centered luminescence exhibiting the temperature responsive behavior in physiological temperature range. In particular, the dimeric 2:2 terbium complexes with the bromo-substituted thiacalix [4] arenes provide a promising basis for design of a temperature-sensitive nanomaterial 39 .…”

“…Moreover, some thiacalix [4]arene derivatives has been recently reported 38,39 as the appropriate ligand environment of Tb 3+ ions to generate the Tb 3+ -centered luminescence exhibiting the temperature responsive behavior in physiological temperature range. In particular, the dimeric 2:2 terbium complexes with the bromo-substituted thiacalix [4] arenes provide a promising basis for design of a temperature-sensitive nanomaterial 39 . This is the reason for focusing on the optimal conditions of an efficient conversion of the complexes from molecular blocks in the organic solutions to the water dispersed hydrophilic nanoparticles.…”