Dual redox-triggered shell-sheddable micelles self-assembled from mPEGylated starch conjugates for rapid drug release

Chen, Mingjia; Gao, Chunmei; Lü, Shaoyu; Chen, Yuanmou; Liu, Mingzhu

doi:10.1039/c5ra23618e

Cited by 31 publications

(8 citation statements)

References 58 publications

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“…However, free DOXI did not have the capability to reach the cancer cell site specifically. Because of this, the great side effect in normal cells was not taken care. − It was very interesting to note that the nanocarrier disrupted through the S–S linker only in the cancer cell because of the presence of GSH. Also, the presence of the acylhydrazine linker demonstrated the sustained release of DOXI at the cancer site.…”

Section: Resultsmentioning

confidence: 99%

Biodegradable Copolymer for Stimuli-Responsive Sustained Release of Doxorubicin

et al. 2016

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Pendent functionalization of biodegradable polymers provides unique importance in biological applications. In this work, we have synthesized a polymeric nanocarrier for the controlled release of the anticancer drug doxorubicin (DOXI). Inspired by the pH responsiveness of acylhydrazine bonds along with the interesting self-assembly behavior of amphiphilic copolymers, this report delineates the development of a PEG-SS-PCL-DOXI copolymer consisting of DOXI, PEG, and a caprolactone backbone. First, the inclusion of a PEG moiety in the copolymer helps to achieve biocompatibility and aqueous solubility as well as a prolonged circulation time of the nanocarrier. Second, an acid-sensitive acylhydrazine-based linkage is chosen to attach DOXI to trigger sustained drug release, whereas the inclusion of an enzymatically cleavable disulfide linkage in the backbone adds to the advantage of backbone biodegradability at the intracellular level.

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Section: Resultsmentioning

confidence: 99%

Biodegradable Copolymer for Stimuli-Responsive Sustained Release of Doxorubicin

et al. 2016

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“…Conversely, the PEG shell would shield the DOX from premature leakage in the physiological environment and its “stealth effect” endowed the cargos longer half‐life in the body 33 . The more dynamic Se–Se bonds (as compared to S–S bonds) 34,35 were positioned between the hydrophobic and hydrophilic domains of the micellar architecture to afford a shell‐sheddable topology and trigger prompt redox‐responsive cleavage of Se–Se bonds and thereby rapid onset and nearly complete release of payloads 36,37 . In this study, the redox‐responsive property of the micelles was probed in the presence of 5 mM GSH, 10 mM GSH, and 0.1% H 2 O 2 .…”

Section: Introductionmentioning

confidence: 89%

“…33 The more dynamic Se-Se bonds (as compared to S-S bonds) 34,35 were positioned between the hydrophobic and hydrophilic domains of the micellar architecture to afford a shell-sheddable topology and trigger prompt redox-responsive cleavage of Se-Se bonds and thereby rapid onset and nearly complete release of payloads. 36,37 In this study, the redox-responsive property of the micelles was probed in the presence of 5 mM GSH, 10 mM GSH, and 0.1% H 2 O 2 . In addition, the DOXreleasing behavior of DOX-loaded 3s-PCL-SeSe-PEG-biotin (DOX@3s-PCL-SeSe-PEG-biotin) micelles was assessed in a simulated physiological environment and intracellular cancer redox pools.…”

Section: Introductionmentioning

confidence: 99%

Biotin‐decorated redox‐responsive micelles from diselenide‐linked star‐shaped copolymers for the targeted delivery and controlled release of doxorubicin in cancer cells

Birhan

Hanurry

Mekonnen

et al. 2022

J of Applied Polymer Sci

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Polymeric micelles (s-PMs) assembled from star-shaped amphiphilic copolymers functionalized with cancer-homing molecules have been shown to have enormous potential to be used as a delivery tool to achieve longer half-life in the bloodstream, cancer-specific internalization, and controlled release of payloads in tumor cells. Considering the unprecedented thermodynamic stability of s-PMs owing to the entanglement of branched arms, we prepared a biotin-decorated and diselenide-linked star-shaped amphiphilic copolymer, 3s-PCL-SeSe-PEG-biotin, which could undergo self-directed clustering to form uniformly distributed s-PMs with a hydrodynamic diameter (D h ) of 76.27 nm.The s-PMs had appreciable doxorubicin (DOX)-loading content (DLC) and encapsulation efficiency (EE) of 5.83 wt% and 71.02%, respectively. The blank and DOX-loaded 3s-PCL-SeSe-PEG-

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“…In this process, starch NPs (SNPs) or starch nanocrystals (SNCs) can be manufactured from ordering, orientation, and packaging of starch molecules in a controlled manner, which can be regulated by means of thermodynamic, such as the self‐assembly process (Jin, ; Kim, Park, & Lim, ; Liu et al., ). Although there are many studies in the development of SNPs and SNCs (Villa, Sanchez, & Rodriguez‐Marin, ), few researches have been carried out in order to analyze the self‐assembly of starch alone and/or together with other compounds in coatings (Ganjaee et al., ), drug delivery systems (Chen, Gao, Lü, Chen, & Liu, ,b; Wu et al., ), medicine to control bleeding (Chen et al., ), and water purification (Kumar, Kumar, & Paul, ).…”

Section: Scps In Foodmentioning

confidence: 99%

Self‐Assembled Carbohydrate Polymers for Food Applications: A Review

Valencia

Zare‬

Makvandi

et al. 2019

Comp Rev Food Sci Food Safe

112

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The self‐assembled natural and synthetic polymers are booming. However, natural polymers obtained from native or modified carbohydrate polymers (CPs), such as celluloses, chitosan, glucans, gums, pectins, and starches, have had special attention as raw material in the manufacture of self‐assembled polymer composite materials having several forms: films, hydrogels, micelles, and particles. The easy manipulation of the architecture of the CPs, as well as their high availability in nature, low cost, and being sustainable and green polymers have been the main positive points in the use of them for different applications. CPs have been used as building blocks for composite structures, and their easy orientation and ordering has given rise to self‐assembled CPs (SCPs). These macromolecules have been little studied for food applications. Nonetheless, their research has grown mainly in the last 5 years as encapsulated food additive wall materials, food coatings, and edible films. The multifaceted properties (systems sensitive to pH, temperature, ionic strength, types of ions, mechanical force, and enzymes) of these devices are leading to the development of advanced food materials. This review article focused on the analysis of SCPs for food applications in order to encourage other research groups for their preparation and implementation.

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Dual redox-triggered shell-sheddable micelles self-assembled from mPEGylated starch conjugates for rapid drug release

Abstract: The new diselenide-linked mPEGylated starch amphiphilic micelles was developed, which could be disrupted in the presence of 0.1% (v/v) H2O2 or 1 mM GSH.

Cited by 31 publications

References 58 publications

Biodegradable Copolymer for Stimuli-Responsive Sustained Release of Doxorubicin

Biodegradable Copolymer for Stimuli-Responsive Sustained Release of Doxorubicin

Biotin‐decorated redox‐responsive micelles from diselenide‐linked star‐shaped copolymers for the targeted delivery and controlled release of doxorubicin in cancer cells

Self‐Assembled Carbohydrate Polymers for Food Applications: A Review

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