Dual stimuli-responsive oligo(ethylene glycol)-based microgels: insight into the role of internal structure in volume phase transitions and loading of magnetic nanoparticles to design stable thermoresponsive hybrid microgels

Boularas, Mohamed; Deniau‐Lejeune, Elise; Alard, Valérie; Tranchant, Jean‐François; Billon, Laurent; Save, Maud

doi:10.1039/c5py01078k

Cited by 43 publications

(32 citation statements)

References 76 publications

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“…30,32 This value (pK 0 =4.5) is close to the pK 0 of linear poly(methacrylic acid) (pK 0 =4.65). Similar results were obtained by M. Boularas et al 33 for nanogels based on the same monomers (MEO 2 MA, OEGMA and MAA).…”

Section: Magnetic Hyperthermia Experimentssupporting

confidence: 89%

Doxorubicin Intracellular Remote Release from Biocompatible Oligo(ethylene glycol) Methyl Ether Methacrylate-Based Magnetic Nanogels Triggered by Magnetic Hyperthermia

Cazares-Cortes

Espinosa

Guigner

et al. 2017

ACS Appl. Mater. Interfaces

114

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Hybrid nanogels, composed of thermoresponsive polymers and superparamagnetic nanoparticles, are attractive nanocarriers for biomedical applications, being able-as a polymer matrix-to uptake and release high quantities of chemotherapeutic agents and-as magnetic nanoparticles-to be heated when exposed to an alternative magnetic field (AMF), better known as magnetic hyperthermia. Herein, biocompatible, pH-responsive, magnetoresponsive, and thermoresponsive nanogels, based on oligo(ethylene glycol) methyl ether methacrylate monomers and a methacrylic acid comonomer were prepared by conventional precipitation radical copolymerization in water, post-assembled by complexation with iron oxide magnetic nanoparticles (MNPs) of maghemite (γ-FeO), and loaded with an anticancer drug (doxorubicin, DOX), for remotely controlled drug release by a "hot spot", as an athermal magnetic hyperthermia strategy against cancer. These nanogels, denoted MagNanoGels, with a hydrodynamic diameter from 328 to 460 nm, as a function of the MNP content, have a swelling-deswelling behavior at their volume phase temperature transition around 47 °C in a physiological medium (pH 7.5), which is above the human body temperature (37 °C). Applying an alternative magnetic field increases the release of DOX by 2-fold, while no macroscopic heating was recorded. This enhanced drug release is due to a shrinking of the polymer network by local heating, as illustrated by the MagNanoGel size decrease under an AMF. In cancer cells, not only do the DOX-MagNanoGels internalize DOX more efficiently than free DOX, but also DOX intracellular release can be remotely triggered under an AMF, in athermal conditions, thus enhancing DOX cytotoxicity.

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Section: Magnetic Hyperthermia Experimentssupporting

confidence: 89%

Doxorubicin Intracellular Remote Release from Biocompatible Oligo(ethylene glycol) Methyl Ether Methacrylate-Based Magnetic Nanogels Triggered by Magnetic Hyperthermia

Cazares-Cortes

Espinosa

Guigner

et al. 2017

ACS Appl. Mater. Interfaces

114

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“…The PRLDA gels show pH‐, temperature‐, and photoresponsive swelling which is programmed by their construction with multiresponsive MG building blocks. For the photocrosslinked gels the smallest volume swelling ratio ( Q ) is 1.4 at pH 5.4 and 37 °C ( Figure A), which is due to temperature‐triggered hydrophobic interaction between MEO 2 MA segments as well as pH‐triggered hydrogen bond formation between protonated COOH groups within MAA . Q increases with decreasing temperature due to hydrogen bonding of MEO 2 MA segments with water.…”

Section: Resultsmentioning

confidence: 99%

Programmed Multiresponsive Hydrogel Assemblies with Light‐Tunable Mechanical Properties, Actuation, and Fluorescence

Lu¹,

Zhu²,

Wu³

et al. 2020

Adv Funct Materials

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Fabrication strategies for programmed hydrogels that provide precise spatial control with predetermined responses to external stimuli are highly desirable. In this study, a partially reversible light‐driven assembly (PRLDA) method is introduced to construct multiresponsive hydrogels utilizing microgel (MG) particle building blocks (swollen diameter of 107 nm). No other material is required to prepare the gels beyond the MGs themselves. Facile preparation of multiresponsive hydrogels that are reversibly responsive to light, pH, and temperature using phototriggered covalent interlinking of coumarin‐based MGs is demonstrated. The gels have phototuneable moduli and swelling ratios and show light‐assisted healing and reshaping. Remarkably, the intrinsic fluorescence of the gels undergoes a reversible light‐triggered wavelength‐shift. The emission peak blueshifted from 420 to 390 nm upon irradiation with 365 nm light. The PRLDA gels can be constructed using either positive or negative photopatterning. It is shown that the gels can be exploited for multiresponsive cytocompatible actuators, grippers, and ON/OFF circuit components as well as anticounterfeit gels. The PRLDA method provides new insight into programmed gel property control and has excellent potential for biomaterial and optoelectronic applications.

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“…12 The most extensively studied thermoresponsive polymer is the poly(N-isopropylacrylamide) (PNIPAAm) with a LCST of 32°C close to the physiological temperature. Over the last ten years, poly(oligo(ethylene glycol) (meth)acrylates) (P(OEG)(M)A) [39][40][41] or poly(N-vinylcaprolactam) (PVCL), 27,42 which also present a LCST near to physiological temperature, have emerged as biocompatible thermoresponsive polymers of interest. Poly(N-vinylcaprolactam) is a 7-membered ring type polymer which is biocompatible, water-soluble, non-ionic and exhibits a LCST in water ranging between 30 and 40°C.…”

Section: Introductionmentioning

confidence: 99%

RAFT/MADIX emulsion copolymerization of vinyl acetate and N-vinylcaprolactam: towards waterborne physically crosslinked thermoresponsive particles

et al. 2017

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Dual stimuli-responsive oligo(ethylene glycol)-based microgels: insight into the role of internal structure in volume phase transitions and loading of magnetic nanoparticles to design stable thermoresponsive hybrid microgels

Abstract: Design of multi-responsive biocompatible P(MEO2MA-co-OEGMA-co-MAA) microgels and their hybrid magnetic couterparts.

Cited by 43 publications

References 76 publications

Doxorubicin Intracellular Remote Release from Biocompatible Oligo(ethylene glycol) Methyl Ether Methacrylate-Based Magnetic Nanogels Triggered by Magnetic Hyperthermia

Doxorubicin Intracellular Remote Release from Biocompatible Oligo(ethylene glycol) Methyl Ether Methacrylate-Based Magnetic Nanogels Triggered by Magnetic Hyperthermia

Programmed Multiresponsive Hydrogel Assemblies with Light‐Tunable Mechanical Properties, Actuation, and Fluorescence

RAFT/MADIX emulsion copolymerization of vinyl acetate and N-vinylcaprolactam: towards waterborne physically crosslinked thermoresponsive particles

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