Dual-targeting SERS-encoded graphene oxide nanocarrier for intracellular co-delivery of doxorubicin and 9-aminoacridine with enhanced combination therapy

Chen, Hui; Xing, Licong; Guo, Huiru; Luo, Caixia; Zhang, Xuedian

doi:10.1039/d1an01237a

Cited by 12 publications

(10 citation statements)

References 60 publications

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“…64 Therefore, carbon-based nanomaterials are ideal candidates. 65,66 Liposome-mediated drug delivery has been of importance. 67 In an effort, TPGS-modified liposomal nanocarriers were designed for DOX delivery.…”

Section: Synthetic Moleculesmentioning

confidence: 99%

(Nano)platforms in breast cancer therapy: Drug/gene delivery, advanced nanocarriers and immunotherapy

Ashrafizadeh

Zarrabi

Bigham

et al. 2023

Medicinal Research Reviews

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Breast cancer is the most malignant tumor in women, and there is no absolute cure for it. Although treatment modalities including surgery, chemotherapy, and radiotherapy are utilized for breast cancer, it is still a life‐threatening disease for humans. Nanomedicine has provided a new opportunity in breast cancer treatment, which is the focus of the current study. The nanocarriers deliver chemotherapeutic agents and natural products, both of which increase cytotoxicity against breast tumor cells and prevent the development of drug resistance. The efficacy of gene therapy is boosted by nanoparticles and the delivery of CRISPR/Cas9, Noncoding RNAs, and RNAi, promoting their potential for gene expression regulation. The drug and gene codelivery by nanoparticles can exert a synergistic impact on breast tumors and enhance cellular uptake via endocytosis. Nanostructures are able to induce photothermal and photodynamic therapy for breast tumor ablation via cell death induction. The nanoparticles can provide tumor microenvironment remodeling and repolarization of macrophages for antitumor immunity. The stimuli‐responsive nanocarriers, including pH‐, redox‐, and light‐sensitive, can mediate targeted suppression of breast tumors. Besides, nanoparticles can provide a diagnosis of breast cancer and detect biomarkers. Various kinds of nanoparticles have been employed for breast cancer therapy, including carbon‐, lipid‐, polymeric‐ and metal‐based nanostructures, which are different in terms of biocompatibility and delivery efficiency.

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Section: Synthetic Moleculesmentioning

confidence: 99%

(Nano)platforms in breast cancer therapy: Drug/gene delivery, advanced nanocarriers and immunotherapy

Ashrafizadeh

Zarrabi

Bigham

et al. 2023

Medicinal Research Reviews

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“…GO conjugated with Au@Ag and Fe 3 O 4 NPs, facilitating it with surface-enhanced Raman scattering spectroscopic (SERS) tracking and magnetic targeting abilities, was able to covalently bind to the anti-HER2 antibody, enabling both active and passive targeting of SKBR3 cells (human breast cancer cells expressed with HER2), was used for co-delivery of DOX and 9-aminoacridine. The nanocarriers were internalized into the lysosomes and exhibited pH-responsive drug release in acidic environment, showed enhanced cancer cytotoxicity compared with nanocarriers loaded with a single drug, and increased cytotoxicity against cancer cells, which was observed even with relatively low concentrations of the drugs [ 146 ]. Nanocomposites fabricated by functionalization of GO with polyvinylpyrrolidone (PVP) and then grafted with Fe 3 O 4 NPs loaded with quercetin exhibited pH-responsive controlled drug release and biocompatibility to non-tumorigenic epithelial HEK 293T cells, with higher toxicity to MDA MB 231 human breast cancer cells than free quercetin.…”

Section: Gbns As Drugs and Nanocarriersmentioning

confidence: 99%

Advances in Biologically Applicable Graphene-Based 2D Nanomaterials

Jampílek

Kráľová

2022

IJMS

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Climate change and increasing contamination of the environment, due to anthropogenic activities, are accompanied with a growing negative impact on human life. Nowadays, humanity is threatened by the increasing incidence of difficult-to-treat cancer and various infectious diseases caused by resistant pathogens, but, on the other hand, ensuring sufficient safe food for balanced human nutrition is threatened by a growing infestation of agriculturally important plants, by various pathogens or by the deteriorating condition of agricultural land. One way to deal with all these undesirable facts is to try to develop technologies and sophisticated materials that could help overcome these negative effects/gloomy prospects. One possibility is to try to use nanotechnology and, within this broad field, to focus also on the study of two-dimensional carbon-based nanomaterials, which have excellent prospects to be used in various economic sectors. In this brief up-to-date overview, attention is paid to recent applications of graphene-based nanomaterials, i.e., graphene, graphene quantum dots, graphene oxide, graphene oxide quantum dots, and reduced graphene oxide. These materials and their various modifications and combinations with other compounds are discussed, regarding their biomedical and agro-ecological applications, i.e., as materials investigated for their antineoplastic and anti-invasive effects, for their effects against various plant pathogens, and as carriers of bioactive agents (drugs, pesticides, fertilizers) as well as materials suitable to be used in theranostics. The negative effects of graphene-based nanomaterials on living organisms, including their mode of action, are analyzed as well.

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“…30–32 GO can interact easily with various organic analyte molecules via π–π stacking to facilitate the transfer of charge from the analyte molecules which makes it an ideal substrate material for various applications in SERS. 6,33,34 The hybridization of plasmonic nanostructures (Au, Ag) with GO has been confirmed for high-performance SERS biosensing and pinpointed Au nanostars (AuNS) as excellent SERS substrates. These heterostructures 35–37 played a pivotal role in the development of dual-mode sensing platforms.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4] The development and design of responsive devices for the detection of T-2 mycotoxins in the food chain is therefore of imperative significance regarding environmental protection, public health, and food safety assessment. 5,6 However, the traditional methods present numerous limitations in satisfying the tough requirements for monitoring toxin concentration. [7][8][9] Biological and chemical sensors with diverse signal output approaches have received tremendous attention owing to their numerous potential applications.…”

Section: Introductionmentioning

confidence: 99%

Novel metal enhanced dual-mode fluorometric and SERS aptasensor incorporating a heterostructure nanoassembly for ultrasensitive T-2 toxin detection

et al. 2023

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Dual-targeting SERS-encoded graphene oxide nanocarrier for intracellular co-delivery of doxorubicin and 9-aminoacridine with enhanced combination therapy

Abstract: A graphene oxide (GO)-based nanocarrier that imparts tumor-selective delivery of dual-drug with enhanced therapeutic index, is introduced. GO is conjugated with Au@Ag and Fe3O4 nanoparticles, which facilitate it with SERS...

Cited by 12 publications

References 60 publications

(Nano)platforms in breast cancer therapy: Drug/gene delivery, advanced nanocarriers and immunotherapy

(Nano)platforms in breast cancer therapy: Drug/gene delivery, advanced nanocarriers and immunotherapy

Advances in Biologically Applicable Graphene-Based 2D Nanomaterials

Novel metal enhanced dual-mode fluorometric and SERS aptasensor incorporating a heterostructure nanoassembly for ultrasensitive T-2 toxin detection

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